Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

(2019) Ping Wang et al.   Nature Communications

Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway

(2019) Mao-mao Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Gout

(2019) Nicola Dalbeth et al.   Nature Reviews Disease Primers

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication

(2018) Jhih-Jia Jhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

(2018) Haipeng Yin et al.   JOURNAL OF IMMUNOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Control of Inflammasome Activation by Phosphorylation

(2018) Tao Gong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Network Pharmacology-Based Validation of Caveolin-1 as a Key Mediator of Ai Du Qing Inhibition of Drug Resistance in Breast Cancer

(2018) Neng Wang et al.   Frontiers in Pharmacology

Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells

(2017) Tereza Nehybová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

NLRP3 inflammasome: common nexus between depression and cardiovascular diseases

(2017) Elísabet Alcocer-Gómez et al.   Nature Reviews Cardiology

Inflammation in gout: mechanisms and therapeutic targets

(2017) Alexander K. So et al.   Nature Reviews Rheumatology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Effect and mechanism of wedelolactone as antioxidant-coumestan on OH-treated mesenchymal stem cells

(2017) Xican Li et al.   Arabian Journal of Chemistry

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice

(2016) Yang Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome

(2016) Koji Otani et al.   Scientific Reports

Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection

(2016) Yi-Dan Liang et al.   Frontiers in Pharmacology

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis

(2015) Mei-Yun Huang et al.   APOPTOSIS

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection

(2015) Hao Pan et al.   Oncotarget

The Second-Generation mTOR Kinase Inhibitor INK128 Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated RAW 264.7 Cells

(2014) Hao Pan et al.   INFLAMMATION

Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

(2014) Laurent L. Reber et al.   Arthritis & Rheumatology

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY