Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships

A novel structural class of coumarin-chalcone fibrates as PPARα/γ agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies

(2017) Handong Niu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge

(2017) Yi Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages

(2017) Seung-Bin Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antifungal activity of umbelliferone derivatives: Synthesis and structure-activity relationships

(2017) Le Pan et al.   MICROBIAL PATHOGENESIS

Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway

(2017) Ke Si Wang et al.   ONCOLOGY REPORTS

QSAR and docking studies of coumarin derivatives as potent HIV-1 integrase inhibitors

(2017) V.K. Srivastav et al.   Arabian Journal of Chemistry

Synthesis of New Tricyclic and Tetracyclic Fused Coumarin Sulfonate Derivatives and Their Inhibitory Effects on LPS-Induced Nitric Oxide and PGE2Productions in RAW 264.7 Macrophages: Part 2

(2016) Mohammed I. El-Gamal et al.   ARCHIV DER PHARMAZIE

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives

(2016) Pavan Srivastava et al.   BIOORGANIC CHEMISTRY

Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

(2016) Chun-Yan Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone

(2016) Xian Li et al.   CURRENT HIV RESEARCH

Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats

(2016) Ezel Taşdemir et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

In vitro antimicrobial and acetylcholinesterase inhibitory activities of coumarins from Ferulago carduchorum

(2016) Fereshteh Golfakhrabadi et al.   MEDICINAL CHEMISTRY RESEARCH

At the interface of antioxidant signalling and cellular function: Key polyphenol effects

(2016) Asimina Kerimi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials

(2016) R-R Wu et al.   MOLECULAR PSYCHIATRY

Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells

(2016) Duk-Yeon Cho et al.   MOLECULES

Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives

(2016) Ping-Ping Song et al.   PEST MANAGEMENT SCIENCE

Imperatorin–pharmacological meaning and analytical clues: profound investigation

(2016) Ewelina Kozioł et al.   PHYTOCHEMISTRY REVIEWS

Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status

(2016) Sagrario Martín-Aragón et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine

(2016) Smita S. Ghare et al.   TOXICOLOGY IN VITRO

A Review on Chemical Profile of Coumarins and their Therapeutic Role in the Treatment of Cancer

(2016) K. Venkata Sairam et al.   Current Drug Delivery

Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

(2016) Noor Shahirah Suparji et al.   PLoS One

Modified calanolides incorporated with furan-2-nitro mimics against Mycobacterium tuberculosis

(2015) Zijie Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

(2015) Almesh Kadakol et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Isofraxidin protects mice from LPS challenge by inhibiting pro-inflammatory cytokines and alleviating histopathological changes

(2015) Ling Liu et al.   IMMUNOBIOLOGY

Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities

(2015) Senguttuvan Jamuna et al.   INDUSTRIAL CROPS AND PRODUCTS

Recent advances and therapeutic journey of coumarins: current status and perspectives

(2015) Kuldipsinh P. Barot et al.   MEDICINAL CHEMISTRY RESEARCH

4D-QSAR studies of coumarin derivatives as HIV-1 integrase 3′-processing inhibitors

(2015) Rajesh B. Patil et al.   MEDICINAL CHEMISTRY RESEARCH

Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells

(2015) SHI-MIN YU et al.   Molecular Medicine Reports

Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats

(2015) Mi-Ok Sim et al.   Nutrition Research and Practice

Negative hydrogen ion production mechanisms

(2015) M. Bacal et al.   Applied Physics Reviews

Vasorelaxing Activity of Two Coumarins from Murraya paniculata Leaves

(2014) Nguyen Manh Cuong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity

(2014) Marina Roussaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents

(2014) Maria Jun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells

(2014) Mei-Hsiang Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Coumestan Inhibits Radical-Induced Oxidation of DNA: Is Hydroxyl a Necessary Functional Group?

(2014) Gao-Lei Xi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Qualitative analysis and enantiospecific determination of angular-type pyranocoumarins in Peucedani Radix using achiral and chiral liquid chromatography coupled with tandem mass spectrometry

(2014) Y.L. Song et al.   JOURNAL OF CHROMATOGRAPHY A

Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway

(2014) Yanjun Cao et al.   Journal of the American Society of Hypertension

Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages

(2013) Hyeon-Lok Jang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current Developments of Coumarin Compounds in Medicinal Chemistry

(2013) Xin-Mei Peng et al.   CURRENT PHARMACEUTICAL DESIGN

Coumarin chalcone fibrates: A new structural class of lipid lowering agents

(2013) Koneni V. Sashidhara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inflammatory markers of cardiovascular disease risk in Portuguese psoriatic patients: relation with narrow-band ultraviolet B and psoralen plus ultraviolet A

(2013) Susana Coimbra et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Psoralen Derivatives as Inhibitors of NF-κB/DNA Interaction: Synthesis, Molecular Modeling, 3D-QSAR, and Biological Evaluation

(2013) Giovanni Marzaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitroactivity of isoimperatorin, alone and in combination, againstMycobacterium tuberculosis

(2013) N. Guo et al.   LETTERS IN APPLIED MICROBIOLOGY

Effects of praeruptorin C on blood pressure and expression of phospholamban in spontaneously hypertensive rats

(2013) Wang Wenjie et al.   PHYTOMEDICINE

Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity

(2013) Jeong-Kook Kim et al.   PLoS One

The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors

(2013) Le Yang et al.   TOXICOLOGY IN VITRO

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

(2013) K. N. Venugopala et al.   Biomed Research International

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: Key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action

(2012) Ramiro Vázquez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives

(2012) Silvia Serra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma

(2012) You-yi Xiong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synthesis and antidyslipidemic activity of chalcone fibrates

(2011) Poonam Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives

(2011) Jie Sun et al.   CHINESE CHEMICAL LETTERS

Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico

(2011) García-Zebadúa Julio César et al.   FITOTERAPIA

Vipirinin, a Coumarin-based HIV-1 Vpr Inhibitor, Interacts with a Hydrophobic Region of VPR

(2011) Eugene Boon Beng Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ANTILISTERIAL POTENTIAL OF IMPERATORIN AND LIMONIN FROM PONCIRUS TRIFOLIATA RAFIN

(2011) ATIQUR RAHMAN et al.   JOURNAL OF FOOD BIOCHEMISTRY

3′-O, 4′-O-aromatic acyl substituted 7,8-pyranocoumarins: a new class of P-glycoprotein modulators

(2011) Xiaoling Shen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans

(2011) Y. L. Song et al.   XENOBIOTICA

Structure–activity relationships of new 4-hydroxy bis-coumarins as radical scavengers and chain-breaking antioxidants

(2010) Vessela D. Kancheva et al.   BIOCHIMIE

Isofraxidin, a Coumarin Component from Acanthopanax senticosus, Inhibits Matrix Metalloproteinase-7 Expression and Cell Invasion of Human Hepatoma Cells

(2010) Taisuke Yamazaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity

(2010) Marina Roussaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives

(2010) Koneni V. Sashidhara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.

(2010) Ender Büyükgüzel et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells

(2009) Tae Jin Kang et al.   ACTA ONCOLOGICA

Anti-inflammatory Effect of Columbianetin on Activated Human Mast Cells

(2009) Hyun-Ja Jeong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dual Anti-oxidative Effects of Fraxetin Isolated from Fraxinus rhinchophylla

(2009) Phuong Thien Thuong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evidence that Bergapten, Independently of its Photoactivation, Enhances p53 Gene Expression and Induces Apoptosis in Human Breast Cancer Cells

(2009) M. Panno et al.   CURRENT CANCER DRUG TARGETS

The Structure and Pharmacological Functions of Coumarins and Their Derivatives

(2009) L. Wu et al.   CURRENT MEDICINAL CHEMISTRY

Anti-angiogenic potential of scopoletin is associated with the inhibition of ERK1/2 activation

(2009) Rong Pan et al.   DRUG DEVELOPMENT RESEARCH

Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells

(2009) Kyong-Hwa Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-arthritic effect of scopoletin, a coumarin compound occurring in Erycibe obtusifolia Benth stems, is associated with decreased angiogenesis in synovium

(2009) Rong Pan et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

A study of the antimicrobial activity of selected naturally occurring and synthetic coumarins

(2009) T. Smyth et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells

(2009) Sang-Heng Kok et al.   ORAL ONCOLOGY

Antioxidant activities of coumarins from Korean medicinal plants and their structure–activity relationships

(2009) Phuong Thien Thuong et al.   PHYTOTHERAPY RESEARCH

Antibacterial and antifungal activities of the crude extract and compounds from Dorstenia turbinata (Moraceae)

(2009) B. Ngameni et al.   SOUTH AFRICAN JOURNAL OF BOTANY

The effects of isoimperatorin isolated from Agelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

(2008) Tae Chul Moon et al.   ARCHIVES OF PHARMACAL RESEARCH

Structure–activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

(2008) Hsiu-Chen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells

(2008) Wang-Fun Fong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effects of xanthotoxin treatment on trichothecene production in Fusarium sporotrichioides

(2008) Nancy J. Alexander et al.   CANADIAN JOURNAL OF MICROBIOLOGY

A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer

(2008) Musiliyu Musa et al.   CURRENT MEDICINAL CHEMISTRY

Fusarium Graminearum Growth Inhibition Due to Glucose Starvation Caused by Osthol

(2008) Zhiqi Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Seselin from Plumbago zeylanica inhibits phytohemagglutinin (PHA)-stimulated cell proliferation in human peripheral blood mononuclear cells

(2008) W.J. Tsai et al.   JOURNAL OF ETHNOPHARMACOLOGY

The structure–activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells

(2008) Tomonori Nakamura et al.   Journal of Natural Medicines

Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells

(2007) Maria E. Riveiro et al.   BIOCHEMICAL PHARMACOLOGY

Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae

(2007) Mauro Mazzei et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin

(2007) Adeline Beillerot et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS