The therapeutic potential of plant flavonoids on rheumatoid arthritis

Safety of biologic DMARDs in RA patients in real life: A systematic literature review and meta-analyses of biologic registers

(2017) Maïté de La Forest Divonne et al.   JOINT BONE SPINE

Recent advances and trends in the liquid-chromatography–mass spectrometry analysis of flavonoids

(2016) André de Villiers et al.   JOURNAL OF CHROMATOGRAPHY A

Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study

(2016) Naoki Ishiguro et al.   Modern Rheumatology

Glucocorticoids and Rheumatoid Arthritis

(2016) Joana Fonseca Ferreira et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Biological Therapy-Induced Systemic Vasculitis

(2016) Luis Arturo Gutiérrez-González   Current Rheumatology Reports

The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis

(2015) Camille Roubille et al.   ANNALS OF THE RHEUMATIC DISEASES

Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis

(2015) C. Gardi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A novel therapeutic approach targeting rheumatoid arthritis by combined administration of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin with reference to pro-inflammatory cytokines, inflammatory enzymes, RANKL and transcription factors

(2015) Farhath Sultana et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-arthritic activity of luteolin in Freund’s complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway

(2015) Fengchao Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protective effect of apigenin on Freund’s complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway

(2015) Xiayun Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antiarthritis Effect of Morin is Associated with Inhibition of Synovial Angiogensis

(2015) Ni Zeng et al.   DRUG DEVELOPMENT RESEARCH

Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1β-induced fibroblast-like synoviocytes through regulating the activation of NF-κB and JAK/STAT-signaling pathways

(2015) Lixia Lou et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity

(2015) Xianglian Yuan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation

(2015) Fang Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis

(2015) Yi-Rong Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the Wnt pathway

(2015) Leslie A. Nash et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Advances in use of immunomodulatory agents—a rheumatology perspective

(2015) Minyoung Her et al.   Nature Reviews Gastroenterology & Hepatology

Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats

(2015) Yasmin Moustafa Ahmed et al.   PHARMACOLOGY

Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines

(2014) Sheikh Fayaz Ahmad et al.   CELLULAR IMMUNOLOGY

Kaempferol Inhibits IL-1β-Stimulated, RANKL-mediated Osteoclastogenesis via Downregulation of MAPKs, c-Fos, and NFATc1

(2014) Won-Seok Lee et al.   INFLAMMATION

Flavonols modulate the effector functions of healthy individuals' immune complex-stimulated neutrophils: A therapeutic perspective for rheumatoid arthritis

(2014) Everton O.L. Santos et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: Comparison with celecoxib

(2014) Hebatallah A. Darwish et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

(2013) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Malvidin-3-O-β glucoside, major grape anthocyanin, inhibits human macrophage-derived inflammatory mediators and decreases clinical scores in arthritic rats

(2013) Alain Decendit et al.   BIOCHEMICAL PHARMACOLOGY

Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis

(2013) Xue Yang et al.   Clinical & Developmental Immunology

Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats

(2013) R. Jeyadevi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis

(2013) Adam Kokotkiewicz et al.   FITOTERAPIA

Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets

(2013) Jae-Kyeong Byun et al.   IMMUNOLOGY LETTERS

Baicalein Inhibits Interleukin-1β-Induced Proliferation of Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2013) Shuo Chen et al.   INFLAMMATION

Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis

(2013) Sharayah Riegsecker et al.   LIFE SCIENCES

B-cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumab and implications for study design

(2013) Venkat Reddy et al.   ARTHRITIS RESEARCH & THERAPY

Pro-apoptotic effect of Epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/Akt/mTOR signaling in rats with collagen-induced arthritis

(2012) Dandan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Combination therapy of dexamethasone with epigallocatechin enhances tibiotarsal bone articulation and modulates oxidative status correlates with cartilage cytokines expression in the early phase of experimental arthritis

(2012) Souvik Roy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages

(2012) Jeong-Eun Huh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

7,3′-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis

(2012) Rong Li et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

A Novel Combination of Methotrexate and Epigallocatechin Attenuates the Overexpression of Pro-inflammatory Cartilage Cytokines and Modulates Antioxidant Status in Adjuvant Arthritic Rats

(2012) Souvik Roy et al.   INFLAMMATION

Quercetin Inhibits IL-1β-Induced Proliferation and Production of MMPs, COX-2, and PGE2 by Rheumatoid Synovial Fibroblast

(2012) Myung-Soon Sung et al.   INFLAMMATION

Therapeutic effect of 7, 3′-dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway

(2012) Rong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis

(2012) Guo-Qing Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of Proinflammatory Biomarkers in THP1 Macrophages by Polyphenols Derived From Chamomile, Meadowsweet and Willow bark

(2012) Elaine M Drummond et al.   PHYTOTHERAPY RESEARCH

Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration

(2012) Sadiq Umar et al.   RHEUMATOLOGY INTERNATIONAL

Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells

(2011) Ah-Reum Seong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of theCitrusflavanone naringin

(2011) Kiichiro Kawaguchi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Genistein Inhibit Cytokines or Growth Factor-Induced Proliferation and Transformation Phenotype in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

(2011) Yujun Zhang et al.   INFLAMMATION

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

(2011) Yoshiomi Oka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Apigenin enhances the cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand in human rheumatoid arthritis fibroblast-like synoviocytes

(2011) Qing-wen Sun et al.   MOLECULAR BIOLOGY REPORTS

Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells

(2010) Eun Mi Choi et al.   CELLULAR IMMUNOLOGY

Myricetin inhibits IL-1β-induced inflammatory mediators in SW982 human synovial sarcoma cells

(2010) Young Soon Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evaluation of Antioxidant and Inhibitory Activities for Different Subclasses Flavonoids on Enzymes for Rheumatoid Arthritis

(2010) Je-Hyuk Lee et al.   JOURNAL OF FOOD SCIENCE

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

7,3′-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation

(2010) Rong Li et al.   PHYTOTHERAPY RESEARCH

Flavonoids as anti-inflammatory agents

(2010) Mauro Serafini et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Treatment of Rat Adjuvant Arthritis with Flavonoid (Detralex®), Methotrexate, and Their Combination

(2009) Jozef Rovenský et al.   Annals of the New York Academy of Sciences

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

(2009) Valerie Gossye et al.   ARTHRITIS AND RHEUMATISM

Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis

(2009) Hiroaki MATSUNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes

(2009) Gu-Choul Shin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dietary Vitamin E and Quercetin Modulate Inflammatory Responses of Collagen-Induced Arthritis in Mice

(2009) Eun-Jin Choi et al.   JOURNAL OF MEDICINAL FOOD

Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity

(2009) Rong Li et al.   PHYTOTHERAPY RESEARCH

A Novel Anti-inflammatory Compound, Artonkin-4′-O-glucoside, from the Leaves ofArtocarpus tonkinensisSuppresses Experimentally Induced Arthritis*

(2009) D. T. N. Dang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocytes

(2009) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: A potential therapeutic benefit for arthritis

(2008) Sze-Kwan Lin et al.   ARTHRITIS AND RHEUMATISM

(−)‐Epigallocatechin‐3‐gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice

(2008) Akio Morinobu et al.   ARTHRITIS AND RHEUMATISM

Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice

(2008) Keisuke Imada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts

(2008) Y HOU et al.   CELL BIOLOGY INTERNATIONAL

Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis

(2008) Pradip Nandi et al.   CURRENT OPINION IN RHEUMATOLOGY

Effects of α-Glucosylhesperidin, a Bioactive Food Material, on Collagen-Induced Arthritis in Mice and Rheumatoid Arthritis in Humans

(2008) Takashi Kometani et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models

(2008) Jae-Dong Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms

(2008) Rong Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Genistein modulate immune responses in collagen-induced rheumatoid arthritis model

(2008) Jingxuan Wang et al.   MATURITAS

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production

(2008) S. Ahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin-3-gallate suppresses TNF-α -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts

(2008) Hee-Jin Yun et al.   RHEUMATOLOGY INTERNATIONAL

Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis

(2008) Tina Kauss et al.   ARTHRITIS RESEARCH & THERAPY