Regulation of Inflammatory Response in Human Osteoarthritic Chondrocytes by Novel Herbal Small Molecules

Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis

(2019) Hui-juan Cao et al.   PHYTOMEDICINE

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

(2018) A. R. Tellegen et al.   DRUG DELIVERY

Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model

(2018) Stefan M. Cokelaere et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Traditional Herbal Formula Xianlinggubao for Pain Control and Function Improvement in Patients with Knee and Hand Osteoarthritis: A Multicenter, Randomized, Open-Label, Controlled Trial

(2018) Fei Wang et al.   Evidence-based Complementary and Alternative Medicine

Natural Products for the Prevention and Treatment of Chronic Inflammatory Diseases: Integrating Traditional Medicine into Modern Chronic Diseases Care

(2018) Ji Hye Kim et al.   Evidence-based Complementary and Alternative Medicine

Analgesic Use in Dutch Patients With Osteoarthritis

(2018) Jacoline J. van den Driest et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Cartilage diseases

(2018) Yamini Krishnan et al.   MATRIX BIOLOGY

A novel icariin type flavonoid from Epimedium pseudowushanense

(2018) Huihui Ti et al.   NATURAL PRODUCT RESEARCH

Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head—A first multicentre, randomised, double-blind, placebo-controlled clinical trial

(2018) Zi-Rong Li et al.   Journal of Orthopaedic Translation

Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies

(2018) ML Vainieri et al.   Acta Biomaterialia

Musculoskeletal conditions may increase the risk of chronic disease: a systematic review and meta-analysis of cohort studies

(2018) Amanda Williams et al.   BMC Medicine

Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair

(2018) Ranjith Kankala et al.   Materials

Total ankle arthroplasty: what are the risks?

(2018) T. M. Clough et al.   Bone & Joint Journal

Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis

(2017) Zhitao Rao et al.   Molecular Medicine Reports

Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes

(2017) Lucas de Abreu Costa et al.   MOLECULES

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement

(2016) Zhen Li et al.   BIOMATERIALS

Low dose aspirin like analgesic and anti-inflammatory activities of mono-hydroxybenzoic acids in stressed rodents

(2016) Saba Anjum Khan et al.   LIFE SCIENCES

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

(2016) Pengzhen Wang et al.   PLoS One

Inhibitory Effects of Epimedium Herb on the Inflammatory Response In Vitro and In Vivo

(2015) You-Chang Oh et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Immunology of Osteoporosis: A Mini-Review

(2015) Peter Pietschmann et al.   GERONTOLOGY

Viscosupplementation for Osteoarthritis of the Knee

(2015) David Jevsevar et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

(2015) Cássia Calixto-Campos et al.   JOURNAL OF NATURAL PRODUCTS

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin

(2015) Xingquan Xu et al.   ARTHRITIS RESEARCH & THERAPY

Human Articular Cartilage Progenitor Cells Are Responsive to Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone-Morphogenetic Protein 2

(2015) Alexander J. Neumann et al.   PLoS One

Rapid Identification of Chemical Constituents in Traditional Chinese Medicine Fufang Preparation Xianling Gubao Capsule by LC-linear Ion Trap/Orbitrap Mass Spectrometry

(2013) Yi Dai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Postmenopausal Osteoporosis: The Role of Immune System Cells

(2013) Maria Felicia Faienza et al.   Clinical & Developmental Immunology

Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model

(2013) Li Zeng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes

(2013) Ying Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

The Future of Osteoarthritis Therapeutics: Emerging Biological Therapy

(2013) A. Mobasheri   Current Rheumatology Reports

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

(2012) Ali Mobasheri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Icariin: a potential promoting compound for cartilage tissue engineering

(2012) D. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs

(2012) Feng Zhu et al.   PLoS One

Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties

(2012) Lucio C. Rovati et al.   Therapeutic Advances in Musculoskeletal Disease

Flavonol Glycosides from Epimedium pubescens

(2011) Fengjuan Tu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes

(2011) Stefan Toegel et al.   Genes and Nutrition

The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis

(2011) H. M. Zhu et al.   OSTEOPOROSIS INTERNATIONAL

5-Hydroxymethylfurfural from Black Garlic Extract Prevents TNFα-induced Monocytic Cell Adhesion to HUVECs by Suppression of Vascular Cell Adhesion Molecule-1 Expression, Reactive Oxygen Species Generation and NF-κB Activation

(2011) Hye Kyung Kim et al.   PHYTOTHERAPY RESEARCH

Response of Human Engineered Cartilage Based on Articular or Nasal Chondrocytes to Interleukin-1β and Low Oxygen

(2011) Celeste Scotti et al.   TISSUE ENGINEERING PART A

Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice

(2011) Amol B. Lende et al.   INFLAMMOPHARMACOLOGY

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis

(2010) Richard F. Loeser   CLINICS IN GERIATRIC MEDICINE

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation

(2010) Man-Hai Liu et al.   NUTRITION RESEARCH

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF  single-chain Fv antibody (ESBA105) designed for local therapeutic use

(2009) D M Urech et al.   ANNALS OF THE RHEUMATIC DISEASES

Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes

(2009) M. Mathy-Hartert et al.   INFLAMMATION RESEARCH

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

(2009) Constanze Csaki et al.   ARTHRITIS RESEARCH & THERAPY

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

COX-2 Selective Inhibitors in the Treatment of Osteoarthritis

(2008) Loren Laine et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM