Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories

The dual reno- and neuro-protective effects of dimethyl fumarate against uremic encephalopathy in a renal ischemia/reperfusion model

(2020) Diaa Ragab et al.   Pharmacological Reports

Centella asiatica prevents D-galactose-Induced cognitive deficits, oxidative stress and neurodegeneration in the adult rat brain

(2020) Zeba Firdaus et al.   DRUG AND CHEMICAL TOXICOLOGY

Dimethyl Fumarate Mitigates Tauopathy in Aβ-Induced Neuroblastoma SH-SY5Y Cells

(2020) Mithun Singh Rajput et al.   NEUROCHEMICAL RESEARCH

Dimethyl fumarate exerts neuroprotection by modulating calcineurin/NFAT1 and NFκB dependent BACE1 activity in Aβ1-42 treated neuroblastoma SH-SY5Y cells

(2020) Mithun Singh Rajput et al.   BRAIN RESEARCH BULLETIN

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

(2019) Heba M. A. Abdelrazek et al.   Oxidative Medicine and Cellular Longevity

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

(2019) Nana Akino et al.   Reproductive Biology and Endocrinology

Involvement of AMP-activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain

(2019) Mariko Saito et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Berberine alleviates amyloid-beta pathogenesis via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice

(2019) Zhi-You Cai et al.   CURRENT MOLECULAR MEDICINE

Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

(2019) Min Jian et al.   Journal of Neuroinflammation

Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

(2019) Firas H. Bazzari et al.   MOLECULES

Phosphorylated Glycogen Synthase Kinase-3β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline

(2019) Boxi Ke et al.   MEDICAL SCIENCE MONITOR

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling

(2019) Shofiul Azam et al.   Frontiers in Immunology

Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling

(2019) Shafiq Ur Rehman et al.   Cells

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Clinical evaluation of dimethyl fumarate for the treatment of relapsing-remitting multiple sclerosis: efficacy, safety, patient experience and adherence

(2019) Bhavya Narapureddy et al.   Patient Preference and Adherence

Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro

(2018) Jun Shen et al.   BEHAVIOURAL BRAIN RESEARCH

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer’s disease

(2018) Irena Majkutewicz et al.   BRAIN RESEARCH

A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis

(2018) Jürgen Brück et al.   EXPERIMENTAL DERMATOLOGY

Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

(2018) Hallel C. Paraiso et al.   Journal of Neuroinflammation

Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

(2018) Ahmed S. Kamel et al.   MOLECULAR NEUROBIOLOGY

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease

(2018) Jennifer N.K. Nyarko et al.   NEUROSCIENCE

Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

(2018) Daniel W. Curry et al.   Journal of Parkinsons Disease

Osoczowe stężenia frakcji adiponektyny u kobiet z chorobą Alzheimera

(2018) Agnieszka Baranowska-Bik et al.   Endokrynologia Polska

Role of Adiponectin in Central Nervous System Disorders

(2018) Jenna Bloemer et al.   NEURAL PLASTICITY

cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

(2018) Haitao Wang et al.   Frontiers in Molecular Neuroscience

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of SUMOylation in cerebral hypoxia and ischemia

(2017) Myriam Peters et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease

(2016) Jelena Osmanovic-Barilar et al.   DRUGS & AGING

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling

(2016) Shawqi H. Alawdi et al.   MOLECULAR NEUROBIOLOGY

Effect of dimethyl fumarate on rats with chronic pancreatitis

(2016) Wen-Xian Zhang et al.   Asian Pacific Journal of Tropical Medicine

NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications

(2016) Saskia M. Leibowitz et al.   Frontiers in Molecular Neuroscience

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

(2015) Benedetta Parodi et al.   ACTA NEUROPATHOLOGICA

Brain-derived neurotrophic factor and its clinical implications

(2015) Siresha Bathina et al.   Archives of Medical Science

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

(2015) Yang Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

(2015) Upinder Kaur et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cognition Enhancing and Neuromodulatory Propensity of Bacopa monniera Extract Against Scopolamine Induced Cognitive Impairments in Rat Hippocampus

(2015) M. D. Pandareesh et al.   NEUROCHEMICAL RESEARCH

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection

(2015) Kalliopi Pitarokoili et al.   PLoS One

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

(2014) Gurdeep Marwarha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet

(2014) Katherine Veras et al.   FEBS Open Bio

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Berberine rescues d-galactose-induced synaptic/memory impairment by regulating the levels of Arc

(2013) Pei-Yan Zhan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

(2013) Yuan-Shih Hu et al.   PLoS One

Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease

(2012) Thomas M. van Himbergen   ARCHIVES OF NEUROLOGY

Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.

(2012) Bruce S. McEwen et al.   BEHAVIORAL NEUROSCIENCE

Effects of dimethyl fumarate on neuroprotection and immunomodulation

(2012) Philipp Albrecht et al.   Journal of Neuroinflammation

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition.

(2010) John P. Aggleton et al.   BEHAVIORAL NEUROSCIENCE

Hormonal Influences on Cognition and Risk for Alzheimer’s Disease

(2010) Sarah C. Janicki et al.   Current Neurology and Neuroscience Reports

Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s disease

(2010) K. Une et al.   EUROPEAN JOURNAL OF NEUROLOGY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Depressive symptoms and risk of dementia: The Framingham Heart Study

(2010) J. S. Saczynski et al.   NEUROLOGY

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation

(2010) Z. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Action of estrogens in the aging brain: Dementia and cognitive aging

(2009) Victor W. Henderson   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Purple Sweet Potato Color Alleviates D-galactose-induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C-mediated Apoptosis

(2009) Jun Lu et al.   BRAIN PATHOLOGY

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Protective actions of sex steroid hormones in Alzheimer’s disease

(2009) Christian J. Pike et al.   FRONTIERS IN NEUROENDOCRINOLOGY

AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression

(2008) Ji-Eun Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES