Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet

(2019) Fan Zheng et al.   Lipids in Health and Disease

Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far

(2019) Firas H. Bazzari et al.   Current Alzheimer Research

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Effect of Aluminum Exposure on Glucose Metabolism and Its Mechanism in Rats

(2018) Xi Wei et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis

(2018) P. Barton Duell et al.   Journal of Clinical Lipidology

Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3β Pathway by Hesperidin in Wistar Rats

(2018) Arokiasamy Justin-Thenmozhi et al.   NEUROTOXICITY RESEARCH

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

(2018) Christian Benedict et al.   Frontiers in Neuroscience

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2–Mediated Water Homeostasis

(2018) Suchun Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidemiology, diagnosis, and treatment of cerebrotendinous xanthomatosis (CTX)

(2017) Gerald Salen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

(2017) Madhavan Nampoothiri et al.   NEUROREPORT

Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy

(2017) Saidan Ding et al.   TOXICOLOGICAL SCIENCES

Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease

(2017) Archontia Kaminari et al.   Scientific Reports

Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion

(2016) M. Hansen et al.   DIABETES OBESITY & METABOLISM

Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test

(2016) Samireh Ghafouri et al.   EPILEPSY RESEARCH

Identification of functional farnesoid X receptors in brain neurons

(2016) Chao Huang et al.   FEBS LETTERS

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

(2016) HONG-MEI ZHANG et al.   Molecular Medicine Reports

Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling

(2016) Shawqi H. Alawdi et al.   MOLECULAR NEUROBIOLOGY

The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissuein vitro: insight into how bile acids decrease obesity

(2016) João Soeiro Teodoro et al.   NMR IN BIOMEDICINE

Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist

(2016) Kenichi Katsurada et al.   Journal of Diabetes Investigation

Bile Acids in Neurodegenerative Disorders

(2016) Hayley D. Ackerman et al.   Frontiers in Aging Neuroscience

Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study

(2016) Lara Frommherz et al.   PLoS One

Brain-derived neurotrophic factor and its clinical implications

(2015) Siresha Bathina et al.   Archives of Medical Science

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance

(2015) Mohamed Sham Shihabudeen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression

(2015) Thiruchelvam Kariharan et al.   NEUROBIOLOGY OF AGING

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride

(2014) Salvatore Giunta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells

(2014) Xiao-Min Xin   WORLD JOURNAL OF GASTROENTEROLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Protective effects of copper against aluminum toxicity on acetylcholinesterase and catecholamine contents of different regions of rat’s brain

(2013) Ali Asghar Moshtaghie et al.   NEUROLOGICAL SCIENCES

Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance

(2013) Yongjie Ma et al.   PHARMACEUTICAL RESEARCH

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

(2012) Rita M. Ramalho et al.   NEUROBIOLOGY OF AGING

The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity

(2011) Suat Çolak et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

The bile acid sensor FXR regulates insulin transcription and secretion

(2010) Barbara Renga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exercise increases insulin signaling in the hippocampus: Physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice

(2010) Alexandre P. Muller et al.   HIPPOCAMPUS

APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease

(2009) J.R. Walton et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

(2008) Hong Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL