Article
Biochemistry & Molecular Biology
T. Mohan Manu, T. Anand, G. R. Sharath Babu, Mahantesh M. Patil, Farhath Khanum
Summary: The present study aimed to investigate the effect of standardised hydroalcoholic extract of Bacopa monniera against isoproterenol induced cardiac stress. The results showed that treatment with the extract significantly improved cardiac dysfunction by maintaining cardiac rhythm and myocardial integrity, and reducing oxidative stress.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Neurosciences
Abhinav Anand, Navneet Khurana, Nemat Ali, Abdullah F. F. AlAsmari, Metab Alharbi, Mohammad Waseem, Neha Sharma
Summary: This study screened herbal constituents and found that vanillin is a safe and effective natural drug candidate for the treatment of Alzheimer's disease (AD). Vanillin exhibited acetylcholinesterase inhibitory activity and improved memory impairment caused by scopolamine in vitro and in vivo. It also showed better antioxidant effects and acetylcholinesterase inhibitory effects than donepezil hydrochloride. However, further research is needed to evaluate its effect on A beta plaques and Tau neurofibrillary tangles in vivo.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Chemistry, Analytical
Zina Fredj, Baljit Singh, Mohamed Bahri, Peiwu Qin, Mohamad Sawan
Summary: Neurotransmitters (NTs) play a crucial role in regulating the functions of the nervous system and imbalances in their concentrations are linked to various neurological and psychotic disorders. Electrochemical biosensors, particularly those utilizing enzymes as recognition elements, have shown great potential for rapid and sensitive detection of NTs. This review highlights recent advances in enzymatic electrochemical biosensors for NTs detection, covering electrode materials, electroanalytical techniques, and applications in complex matrices and in vivo monitoring. Challenges and future prospects for the development of enzyme-based electrochemical biosensors for NTs detection are also discussed.
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Environmental Sciences
Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasamy
Summary: Neurotoxic pesticides pose a severe threat to humans and the environment, accumulating in the food chain and persisting in the environment to cause long-term exposure and adverse effects on non-target organisms. Accurate and reliable detection of these pesticides and associated neurotransmitters is crucial for clinical applications. Acetylcholinesterase (AchE) biosensors have emerged as a sensitive tool for electrochemical detection, showcasing tremendous potential in various fields.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Tiantian Zhao, Saiyi Zhong, Jucai Xu, Wenjuan Jiao, Weifeng Liu, Lihua Huang, Yehui Zhang, Yousheng Zhang
Summary: PAYCS has positive effects on memory improvement and alleviation of oxidative and inflammatory stress through the modulation of gut microbiota and metabolites.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Razvan Stefan Boiangiu, Eyup Bagci, Gabriela Dumitru, Lucian Hritcu, Elena Todirascu-Ciornea
Summary: This study investigates the protective effect of Angelica purpurascens essential oil (APO) on memory impairments induced by scopolamine in zebrafish. The results show that APO can restore cholinergic system function and improve brain antioxidant state, thereby alleviating the memory deficits.
Article
Biochemistry & Molecular Biology
Chantana Boonyarat, Chavi Yenjai, Orawan Monthakantirat, Rawiwun Kaewamatawong, Pattaporn Poonsawas, Jinda Wangboonskul, Suchada Chaiwiwatrakul, Pornthip Waiwut
Summary: This study investigates the effects of the root-bark extract of Clausena harmandiana and its active constituents on various pharmacological activities related to Alzheimer's disease. The extract and its compounds show antioxidant effects, inhibit A beta aggregation and AChE function, and provide neuroprotection against oxidative stress and A beta toxicity. Additionally, they improve cognitive impairment induced by scopolamine.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Ching-Chiung Wang, Yi-Shan Lee, Yi-Yan Sie, Chi- Chang, Wen-Chi Hou
Summary: Resveratrol tetramers of hopeaphenol, vitisin A, and vitisin B show potential in improving degenerative disorders.
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Shyr-Yi Lin, Yi-Shan Lee, Ching-Chiung Wang, Wen-Chi Hou
Summary: Agricultural waste from water caltrop hulls was extracted and shown to have AChE inhibitory activities, free radical scavenging activities, and anti-non-enzymatic protein glycation effects. Several compounds with strong AChE inhibitory activities and anti-amyloid 13 peptide aggregation effects were identified. Additionally, treatment with the extracted compounds or water caltrop hull extracts improved learning behavior in mice with induced amnesia.
Article
Environmental Sciences
Juan Bellas, Diego Rial, Juliana Valdes, Leticia Vidal-Linan, Juan Bertucci, Soledad Muniategui, Victor M. Leon, Juan A. Campillo
Summary: This study investigates the effects of three organic pollutants (chlorpyrifos, triphenyl phosphate, bisphenol A) on sea urchin larvae. The results show that chlorpyrifos has the highest toxicity, attributed to oxidative stress, modulation of acetylcholinesterase response, and reduced detoxification efficacy. The study also identifies glutathione reductase activity as a reliable biomarker of exposure for sea urchin early-life stages.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yue Zhao, Yifei Dong, Qi Ge, Pengbo Cui, Na Sun, Songyi Lin
Summary: NDEELNK exerts neuroprotective effects by improving ACh levels and reducing AChE activity in PC12 cells, while also increasing SOD activity and decreasing ROS production to reduce mitochondrial dysfunction and enhance energy metabolism. The interaction between NDEELNK backbone and AChE through hydrophobic and hydrogen bonds was confirmed by molecular docking.
Article
Biochemistry & Molecular Biology
Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee, Efthimios M. C. Skoulakis, Annamaria Morelli
Summary: This study investigated the neuroprotective effects of Dendropanax morbifera leaves and stems (DMLS) water extract on scopolamine-induced memory impairment in mice. The results revealed that DMLS protected neuronal cells from neurotoxicity and reduced oxidative stress. Animal studies showed that oral ingestion of DMLS improved memory impairment and enhanced memory abilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Shahnaz Khan, Hidayat Ullah Khan, Farman Ali Khan, Afzal Shah, Abdul Wadood, Shujaat Ahmad, Mazen Almehmadi, Ahad Amer Alsaiari, Farid Ullah Shah, Naveed Kamran
Summary: This study aimed to determine the efficacy and dose response of nuciferine, norcoclaurine, and crude extract of Nelumbo nucifera in managing diabetes, Alzheimer's disease, and related allergies. The results showed that these substances significantly reduced blood glucose levels, restored body weight, and improved antioxidant enzyme activity.
Article
Plant Sciences
Ze-Xing Wang, Wen-Wen Lian, Jun He, Xiao-Li He, Yu-Ming Wang, Chen-Hao Pan, Mei Li, Wei-Ku Zhang, Lian-Qi Liu, Jie-Kun Xu
Summary: The study found that cornuside can improve cognitive dysfunction induced by scopolamine, showing therapeutic effects in behavioral tests. In addition, cornuside can exert its effects by modulating neurotransmitters and alleviating oxidative stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
M. D. Pandareesh, R. B. Mythri, M. M. Srinivas Bharath
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Biochemistry & Molecular Biology
M. D. Pandareesh, M. K. Shrivash, H. N. Naveen Kumar, K. Misra, M. M. Srinivas Bharath
NEUROCHEMICAL RESEARCH
(2016)
Article
Microbiology
Pratiksha V. Bhat, M. D. Pandareesh, Farhath Khanum, Anand Tamatam
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Rajeswara Babu Mythri, Narayana Reddy Raghunath, Santosh Chandrakant Narwade, Mirazkar Dasharatha Rao Pandareesh, Kollarkandi Rajesh Sabitha, Mohamad Aiyaz, Bipin Chand, Manas Sule, Krittika Ghosh, Senthil Kumar, Bhagyalakshmi Shankarappa, Soundarya Soundararajan, Phalguni Anand Alladi, Meera Purushottam, Narayanappa Gayathri, Deepti Dileep Deobagkar, Thenkanidiyoor Rao Laxmi, Muchukunte Mukunda Srinivas Bharath
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Environmental Sciences
Ved Chauhan, Syian Srikumar, Sarah Aamer, Mirazkar D. Pandareesh, Abha Chauhan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2017)
Review
Neurosciences
M. D. Pandareesh, Hemanth Kumar Kandikattu, Sakina Razack, Narayanappa Amruta, Ramesh Choudhari, Ajit Vikram, Prakash Doddapattar
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2018)
Article
Neurosciences
Mirazkar D. Pandareesh, Ved Chauhan, Abha Chauhan
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Biotechnology & Applied Microbiology
M. D. Pandareesh, T. Anand, Pratiksha V. Bhat
Article
Food Science & Technology
T. Anand, K. Bhanu Prakash, M. D. Pandareesh, Farhath Khanum
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2014)
Article
Biochemistry & Molecular Biology
M. D. Pandareesh, T. Anand
NEUROCHEMICAL RESEARCH
(2014)
Article
Neurosciences
Navya Lakkappa, Praveen T. Krishnamurthy, M. D. Pandareesh, Bruce D. Hammock, Sung Hee Hwang
Article
Pharmacology & Pharmacy
T. Mohan Manu, T. Anand, M. D. Pandareesh, P. Bhuvanesh Kumar, Farhath Khanum
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Review
Endocrinology & Metabolism
Mirazkar D. Pandareesh, Vivek H. Kameshwar, Kullaiah Byrappa
Summary: Prostate cancer is mainly caused by genetic and epigenetic changes, as well as inflammation, with mutations in somatic genes being a key factor. In addition to genetic mutations, inflammation plays a significant role in the development of human cancer.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
N. Lakkappa, P. T. Krishnamurthy, M. D. Pandareesh, M. M. Srinivas Bharath, B. D. Hammock, S. H. Hwang
JOURNAL OF NEUROCHEMISTRY
(2017)