Positron emission tomography in multiple sclerosis — straight to the target

Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal

(2021) Fernando Dangond et al.   Nature Reviews Neurology

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Supervised clustering for TSPO PET imaging

(2021) Julia Schubert et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis

(2021) Emilie Poirion et al.   NEUROLOGY

Activated microglia do not increase 18 kDa translocator protein ( TSPO ) expression in the multiple sclerosis brain

(2021) Erik Nutma et al.   GLIA

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

(2020) David Matuskey et al.   ANNALS OF NEUROLOGY

Individual mapping of innate immune cell activation is a candidate marker of patient-specific trajectories of disability worsening in Multiple Sclerosis

(2020) Benedetta Bodini et al.   JOURNAL OF NUCLEAR MEDICINE

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

(2020) Ellis Chika Onwordi et al.   Nature Communications

Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers

(2020) Sofia Rodríguez-Rangel et al.   Scientific Reports

Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging

(2020) Svetlana Bezukladova et al.   Neurology-Neuroimmunology & Neuroinflammation

Astrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PET

(2020) Hiroki Kato et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis

(2020) Yeona Kang et al.   MOLECULAR IMAGING AND BIOLOGY

Amyloid PET findings in multiple sclerosis are associated with cognitive decline at 18 months

(2020) Vanesa Pytel et al.   Multiple Sclerosis and Related Disorders

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

(2020) Katharina Jäckle et al.   BRAIN

Mechanisms underlying progression in multiple sclerosis

(2020) Martina Absinta et al.   CURRENT OPINION IN NEUROLOGY

Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain

(2020) Ayla Mansur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation PET Imaging: Current Opinion and Future Directions

(2020) Poorva Jain et al.   JOURNAL OF NUCLEAR MEDICINE

Remyelination in multiple sclerosis: from basic science to clinical translation

(2020) Catherine Lubetzki et al.   LANCET NEUROLOGY

Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

(2020) Laura Starost et al.   ACTA NEUROPATHOLOGICA

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

(2020) Marcus Sucksdorff et al.   BRAIN

Head-to-Head Comparison of the Two MAO-B Radioligands, 18F-THK5351 and 11C-L-Deprenyl, to Visualize Astrogliosis in Patients With Neurological Disorders

(2020) Kenji Ishibashi et al.   CLINICAL NUCLEAR MEDICINE

Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [ 11 C]UCB‐J positron emission tomography study

(2020) Sjoerd J. Finnema et al.   EPILEPSIA

Towards treating progressive multiple sclerosis

(2020) Alan Thompson et al.   Nature Reviews Neurology

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

An interactive meta-analysis of MRI biomarkers of myelin

(2020) Matteo Mancini et al.   eLife

Predicting PET-derived myelin content from multisequence MRI for individual longitudinal analysis in multiple sclerosis

(2020) Wen Wei et al.   NEUROIMAGE

Myelin quantification with MRI: A systematic review of accuracy and reproducibility

(2020) Chris W.J. van der Weijden et al.   NEUROIMAGE

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MS progression is predominantly driven by age-related mechanisms – NO

(2019) Marisa McGinley et al.   Multiple Sclerosis Journal

Association between pathological and MRI findings in multiple sclerosis

(2019) Massimo Filippi et al.   LANCET NEUROLOGY

Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis

(2019) Julia J Schubert et al.   JOURNAL OF NUCLEAR MEDICINE

PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases

(2019) Christine Ghadery et al.   Current Neurology and Neuroscience Reports

Novel 18F-Labeled Radioligands for Positron Emission Tomography Imaging of Myelination in the Central Nervous System

(2019) Anand Dev Tiwari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET

(2019) Valeria T Barletta et al.   Multiple Sclerosis Journal

Targeting mitochondria to protect axons in progressive MS

(2019) Graham Campbell et al.   NEUROSCIENCE LETTERS

Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis

(2019) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Positron Emission Tomography Neuroimaging

(2019) Jacob M. Hooker et al.   Annual Review of Biomedical Engineering

18F-THK5351 PET Can Identify Astrogliosis in Multiple Sclerosis Plaques

(2019) Kenji Ishibashi et al.   CLINICAL NUCLEAR MEDICINE

Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J

(2019) Ayla Mansur et al.   JOURNAL OF NUCLEAR MEDICINE

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

Natalizumab treatment reduces microglial activation in the white matter of the MS brain

(2019) Marcus Sucksdorff et al.   Neurology-Neuroimmunology & Neuroinflammation

Gray matter microglial activation in relapsing vs progressive MS

(2019) Tarun Singhal et al.   Neurology-Neuroimmunology & Neuroinflammation

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

(2019) Heather Wilson et al.   BRAIN

PennPET Explorer: Human Imaging on a Whole-body Imager

(2019) Austin R Pantel et al.   JOURNAL OF NUCLEAR MEDICINE

Chronic inflammation in multiple sclerosis — seeing what was always there

(2019) Paul M. Matthews   Nature Reviews Neurology

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

(2019) Martina Absinta et al.   JAMA Neurology

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

(2019) Erik Nutma et al.   BRAIN

[18F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis

(2019) Antonio Carotenuto et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Repurposing radiotracers for myelin imaging: a study comparing 18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB

(2019) Sylvain Auvity et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Sensors for Positron Emission Tomography Applications

(2019) Jiang et al.   SENSORS

[11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis

(2019) Robert H.F. Carvalho et al.   Multiple Sclerosis and Related Disorders

Predicting PET-derived demyelination from multimodal MRI using sketcher-refiner adversarial training for multiple sclerosis

(2019) Wen Wei et al.   MEDICAL IMAGE ANALYSIS

Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability?

(2018) Bruno Stankoff et al.   BRAIN PATHOLOGY

18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis

(2018) Tarun Singhal et al.   CLINICAL NUCLEAR MEDICINE

Evaluation of11C-BU99008, a positron emission tomography ligand for the Imidazoline2binding site in human brain

(2018) Robin J. Tyacke et al.   JOURNAL OF NUCLEAR MEDICINE

Much, if not all, of the cortical damage in MS can be attributed to the microglial cell – Yes

(2018) Thecla A van Wageningen et al.   Multiple Sclerosis Journal

The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation - A biochemical and histological validation study

(2018) Simon Hametner et al.   NEUROIMAGE

Development of a PET radioligand for potassium channels to image CNS demyelination

(2018) Pedro Brugarolas et al.   Scientific Reports

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Much, if not all, of the cortical damage in MS can be attributed to the microglial cell – Yes

(2018) Thecla A van Wageningen et al.   Multiple Sclerosis Journal

Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study

(2018) Bruce D Trapp et al.   LANCET NEUROLOGY

TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward

(2018) Tomás R. Guilarte   PHARMACOLOGY & THERAPEUTICS

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

Amyloid PET as a marker of normal-appearing white matter early damage in multiple sclerosis: correlation with CSF β-amyloid levels and brain volumes

(2018) Anna M. Pietroboni et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Ultrahigh field imaging of myelin disease models: Toward specific markers of myelin integrity?

(2018) Alexandra Petiet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET

(2018) Marloes H. J. Hagens et al.   Journal of Neuroinflammation

Ultra–Low-Dose 18F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs

(2018) Kevin T. Chen et al.   RADIOLOGY

The Dawn of a New Era in Low-Dose PET Imaging

(2018) Ciprian Catana   RADIOLOGY

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination

(2017) Verena Schultz et al.   GLIA

Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies

(2017) Daniel García-Lorenzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System

(2017) Chunying Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

(2017) Wissam Beaino et al.   Journal of Neuroinflammation

Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

(2017) Shailender Singh et al.   Journal of Neuroinflammation

Imaging B Cells in a Mouse Model of Multiple Sclerosis Using64Cu-Rituximab PET

(2017) Michelle L. James et al.   JOURNAL OF NUCLEAR MEDICINE

11 C-PBR28 and 18 F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis

(2017) Gourab Datta et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of the Effect of Fingolimod Treatment on Microglial Activation Using Serial PET Imaging in Multiple Sclerosis

(2017) Marcus Sucksdorff et al.   JOURNAL OF NUCLEAR MEDICINE

Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis

(2017) Burcu Zeydan et al.   Multiple Sclerosis Journal

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

(2017) Kok Pin Ng et al.   Alzheimers Research & Therapy

Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis

(2017) Burcu Zeydan et al.   Multiple Sclerosis Journal

Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging

(2016) Assunta Dal-Bianco et al.   ACTA NEUROPATHOLOGICA

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

(2016) Benedetta Bodini et al.   ANNALS OF NEUROLOGY

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

(2016) Lukas Haider et al.   BRAIN

Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging

(2016) Victor W. Pike   CURRENT MEDICINAL CHEMISTRY

Glial biomarkers in human central nervous system disease

(2016) Gwenn A. Garden et al.   GLIA

Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?

(2016) Frederick Bonsack et al.   Journal of Neuroinflammation

Neurodegeneration in multiple sclerosis and neuromyelitis optica

(2016) Izumi Kawachi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

The neuronal component of gray matter damage in multiple sclerosis: A [11C]flumazenil positron emission tomography study

(2015) Léorah Freeman et al.   ANNALS OF NEUROLOGY

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

Amyloid PET imaging in multiple sclerosis: an 18F-florbetaben study

(2015) Jordi A. Matías-Guiu et al.   BMC Neurology

Quantification of [11C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

(2015) Mattia Veronese et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches

(2015) Matteo Tonietto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

(2015) C. H. Lyoo et al.   JOURNAL OF NUCLEAR MEDICINE

Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET

(2015) Y. J. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

A Philosophy for CNS Radiotracer Design

(2014) Genevieve C. Van de Bittner et al.   ACCOUNTS OF CHEMICAL RESEARCH

Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome

(2014) Paolo Giannetti et al.   BRAIN

PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

(2014) Daniele de Paula Faria et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Mechanisms of white matter damage in multiple sclerosis

(2014) Hans Lassmann   GLIA

Automated Reference Region Extraction and Population-Based Input Function for Brain [11C]TMSX PET Image Analyses

(2014) Eero Rissanen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Simplified Reference Tissue Model: Model Assumption Violations and Their Impact on Binding Potential

(2014) Cristian A Salinas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using PET Imaging and the Radioligand 11C-PK11195

(2014) E. Rissanen et al.   JOURNAL OF NUCLEAR MEDICINE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study

(2014) Paolo Giannetti et al.   NEUROBIOLOGY OF DISEASE

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

(2014) Kazushiro Takata et al.   PLoS One

Longitudinal positron emission tomography imaging for monitoring myelin repair in the spinal cord

(2013) Chunying Wu et al.   ANNALS OF NEUROLOGY

Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study

(2013) Eero Rissanen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier

(2012) Stina Syvänen et al.   ACS Chemical Neuroscience

Identification of the Protein Target of Myelin-Binding Ligands by Immunohistochemistry and Biochemical Analyses

(2012) Anshika Bajaj et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

18F-FDG PET Detects Inflammatory Infiltrates in Spinal Cord Experimental Autoimmune Encephalomyelitis Lesions

(2012) D. Buck et al.   JOURNAL OF NUCLEAR MEDICINE

Increased PK11195 PET binding in the cortex of patients with MS correlates with disability

(2012) M. Politis et al.   NEUROLOGY

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Design, Synthesis, and Evaluation of Coumarin-Based Molecular Probes for Imaging of Myelination

(2011) Changning Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial changes associated with demyelination: Consequences for axonal integrity

(2011) Graham R. Campbell et al.   MITOCHONDRION

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole

(2010) Bruno Stankoff et al.   ANNALS OF NEUROLOGY

A novel PET marker for in vivo quantification of myelination

(2010) Chunying Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Standards for PET Image Acquisition and Quantitative Data Analysis

(2009) R. Boellaard   JOURNAL OF NUCLEAR MEDICINE

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Whole-Body PET/CT Scanning: Estimation of Radiation Dose and Cancer Risk

(2009) Bingsheng Huang et al.   RADIOLOGY

18F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis

(2009) Matthias Nahrendorf et al.   JACC-Cardiovascular Imaging