Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J

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Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology

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Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies

(2019) Amber Berdenis van Berlekom et al.   SCHIZOPHRENIA BULLETIN

Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

Assessment of a white matter reference region for 11C-UCB-J PET quantification

(2019) Samantha Rossano et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Schizophrenia—An Overview

(2019) Robert A. McCutcheon et al.   JAMA Psychiatry

Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures

(2018) Emanuele Felice Osimo et al.   MOLECULAR PSYCHIATRY

How Many Patients With Schizophrenia Do Not Respond to Antipsychotic Drugs in the Short Term? An Analysis Based on Individual Patient Data From Randomized Controlled Trials

(2018) Myrto T Samara et al.   SCHIZOPHRENIA BULLETIN

Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis

(2018) Aisling O’Neill et al.   SCHIZOPHRENIA BULLETIN

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans

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Imaging Synaptic Density: A Different Look at Neurologic Diseases

(2017) Eugenii A. Rabiner   JOURNAL OF NUCLEAR MEDICINE

Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors

(2017) A. Demjaha et al.   PSYCHOLOGICAL MEDICINE

Task and resting-state fMRI studies in first-episode schizophrenia: A systematic review

(2017) Tumbwene E. Mwansisya et al.   SCHIZOPHRENIA RESEARCH

Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia

(2017) Stefan P. Brugger et al.   JAMA Psychiatry

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

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Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study

(2016) Peter S. Bloomfield et al.   AMERICAN JOURNAL OF PSYCHIATRY

Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

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Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss

(2016) W. R. Crum et al.   PSYCHOLOGICAL MEDICINE

Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses

(2016) J. Lally et al.   PSYCHOLOGICAL MEDICINE

Dose Equivalents for Antipsychotic Drugs: The DDD Method: Table 1.

(2016) Stefan Leucht et al.   SCHIZOPHRENIA BULLETIN

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

(2015) Marie-Caroline Cotel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Dendritic spine alterations in schizophrenia

(2015) Caitlin E. Moyer et al.   NEUROSCIENCE LETTERS

Effects of antipsychotic drugs on the expression of synapse-associated proteins in the frontal cortex of rats subjected to immobilization stress

(2015) Mi Kyoung Seo et al.   PSYCHIATRY RESEARCH

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Reduced Cortical Volume and Elevated Astrocyte Density in Rats Chronically Treated With Antipsychotic Drugs—Linking Magnetic Resonance Imaging Findings to Cellular Pathology

(2013) Anthony C. Vernon et al.   BIOLOGICAL PSYCHIATRY

Expression of SV2 isoforms during rodent brain development

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Schizophrenia: an integrated sociodevelopmental-cognitive model

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Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness

(2013) Robert E McCullumsmith et al.   NEUROPSYCHOPHARMACOLOGY

Contrasting Effects of Haloperidol and Lithium on Rodent Brain Structure: A Magnetic Resonance Imaging Study with Postmortem Confirmation

(2012) Anthony C. Vernon et al.   BIOLOGICAL PSYCHIATRY

Levetiracetam has an activity-dependent effect on inhibitory transmission

(2012) Anna L. Meehan et al.   EPILEPSIA

Use-Dependent Inhibition of Synaptic Transmission by the Secretion of Intravesicularly Accumulated Antipsychotic Drugs

(2012) Carsten H. Tischbirek et al.   NEURON

Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice

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Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

(2012) Manuel Mattheisen et al.   SCHIZOPHRENIA RESEARCH

Effect of Chronic Antipsychotic Treatment on Brain Structure: A Serial Magnetic Resonance Imaging Study with Ex Vivo and Postmortem Confirmation

(2011) Anthony C. Vernon et al.   BIOLOGICAL PSYCHIATRY

Protein Quantification at the Single Vesicle Level Reveals That a Subset of Synaptic Vesicle Proteins Are Trafficked with High Precision

(2011) S. A. Mutch et al.   JOURNAL OF NEUROSCIENCE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Phencyclidine-induced Loss of Asymmetric Spine Synapses in Rodent Prefrontal Cortex is Reversed by Acute and Chronic Treatment with Olanzapine

(2011) John D Elsworth et al.   NEUROPSYCHOPHARMACOLOGY

Cortical Thickness and Subcortical Volumes in Schizophrenia and Bipolar Disorder

(2010) Lars M. Rimol et al.   BIOLOGICAL PSYCHIATRY

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy

(2010) Andri C. Tziortzi et al.   NEUROIMAGE

SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis

(2009) W.-P. Chang et al.   JOURNAL OF NEUROSCIENCE

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

(2009) K. E. Stephan et al.   SCHIZOPHRENIA BULLETIN

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

(2008) Robert A Sweet et al.   NEUROPSYCHOPHARMACOLOGY

Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum

(2008) Joann Mudge et al.   PLoS One