Mechanisms of white matter damage in multiple sclerosis

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Demyelinating Myelin Oligodendrocyte Glycoprotein-Specific Autoantibody Response Is Focused on One Dominant Conformational Epitope Region in Rodents

(2014) C. Breithaupt et al.   JOURNAL OF IMMUNOLOGY

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

(2013) Tatsuro Misu et al.   ACTA NEUROPATHOLOGICA

Oligodendrocyte Progenitor Cell Susceptibility to Injury in Multiple Sclerosis

(2013) Qiao-Ling Cui et al.   AMERICAN JOURNAL OF PATHOLOGY

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

(2013) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

(2012) Kyriaki Markoullis et al.   ACTA NEUROPATHOLOGICA

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

(2012) Wolfgang Brück et al.   ACTA NEUROPATHOLOGICA

Anti–Myelin Oligodendrocyte Glycoprotein Antibodies in Pediatric Patients With Optic Neuritis

(2012) Kevin Rostasy et al.   ARCHIVES OF NEUROLOGY

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

(2012) James Kolasinski et al.   BRAIN

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

(2012) Sung R. Choi et al.   BRAIN

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

In Vitro and In Vivo Models of Multiple Sclerosis

(2012) Baukje J. van der Star et al.   CNS & Neurological Disorders-Drug Targets

Mitochondrial sirtuins - a new therapeutic target for repair and protection in multiple sclerosis

(2012) C. M. Rice et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oligodendrocytes Enforce Immune Tolerance of the Uninfected Brain by Purging the Peripheral Repertoire of Autoreactive CD8+ T Cells

(2012) Shin-Young Na et al.   IMMUNITY

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

(2012) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Myelination

(2012) Susan C. Barnett et al.   NEUROSCIENTIST

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

(2012) Rajneesh Srivastava et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges

(2012) Kimmy Su et al.   Frontiers in Physiology

Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla

(2011) F. Bagnato et al.   BRAIN

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Preactive Multiple Sclerosis Lesions Offer Novel Clues for Neuroprotective Therapeutic Strategies

(2011) Johannes M. van Noort et al.   CNS & Neurological Disorders-Drug Targets

Pathogenic implications of iron accumulation in multiple sclerosis

(2011) Rachel Williams et al.   JOURNAL OF NEUROCHEMISTRY

Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

(2011) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Review: The architecture of inflammatory demyelinating lesions: implications for studies on pathogenesis

(2011) H. Lassmann   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Aquaporin-4 astrocytopathy in Baló’s disease

(2010) Takeshi Matsuoka et al.   ACTA NEUROPATHOLOGICA

Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

(2010) Rakhi Sharma et al.   ACTA NEUROPATHOLOGICA

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords

(2010) Géraldine Androdias et al.   ANNALS OF NEUROLOGY

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Imaging Cortical Lesions in Multiple Sclerosis With Ultra–High-Field Magnetic Resonance Imaging

(2010) David Pitt et al.   ARCHIVES OF NEUROLOGY

Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury

(2010) Romain Marignier et al.   BRAIN

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death

(2010) S. Veto et al.   BRAIN

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions

(2010) Jack van Horssen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antigen presentation in EAE: role of microglia, macrophages and dendritic cells

(2010) Beatriz Almolda   Frontiers in Bioscience-Landmark

Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes

(2010) Iryna Ziabreva et al.   GLIA

Laquinimod suppress antigen presentation in relapsing–remitting multiple sclerosis: In-vitro high-throughput gene expression study

(2010) M. Gurevich et al.   JOURNAL OF NEUROIMMUNOLOGY

How factors secreted from astrocytes impact myelin repair

(2010) Craig S. Moore et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes

(2010) John DE Parratt et al.   Multiple Sclerosis Journal

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis

(2009) Thomas Zeis et al.   BRAIN PATHOLOGY

Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis

(2009) D. Moharregh-Khiabani et al.   Current Neuropharmacology

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures

(2009) Robert P Lisak et al.   Journal of Neuroinflammation

Enhanced number and activity of mitochondria in multiple sclerosis lesions

(2009) Maarten E Witte et al.   JOURNAL OF PATHOLOGY

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Endoplasmic reticulum stress in disorders of myelinating cells

(2009) Wensheng Lin et al.   NATURE NEUROSCIENCE

Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach

(2008) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Homogeneity of active demyelinating lesions in established multiple sclerosis

(2008) Esther C. W. Breij et al.   ANNALS OF NEUROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system

(2008) Shin-Young Na et al.   BRAIN

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

(2008) J. van Horssen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

(2008) Kryslaine O. Lopes et al.   GLIA

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

(2008) Shannon R. Hinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage

(2008) K. I. Rathore et al.   JOURNAL OF NEUROSCIENCE

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Elevated myeloperoxidase activity in white matter in multiple sclerosis

(2008) Elizabeth Gray et al.   NEUROSCIENCE LETTERS

Cortical demyelination in PML and MS: Similarities and differences

(2007) N. M. Moll et al.   NEUROLOGY