Immune cell compartmentalization for brain surveillance and protection

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Bacille Calmette-Guérin Attenuates Vascular Amyloid Pathology and Maximizes Synaptic Preservation in APP/PS1 Mice Following Active Amyloid-β Immunotherapy

(2021) Zejie Zuo et al.   NEUROBIOLOGY OF AGING

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

A cellular and spatial map of the choroid plexus across brain ventricles and ages

(2021) Neil Dani et al.   CELL

Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice

(2021) Feng Xue et al.   NEUROBIOLOGY OF DISEASE

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

(2021) Simone Brioschi et al.   SCIENCE

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Perivascular spaces in the brain: anatomy, physiology and pathology

(2020) Joanna M. Wardlaw et al.   Nature Reviews Neurology

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

(2020) Sterling B. Ortega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

Brain control of humoral immune responses amenable to behavioural modulation

(2020) Xu Zhang et al.   NATURE

Defining molecular identity and fates of CNS-border associated macrophages after ischemic stroke in rodents and humans

(2020) Wenson D. Rajan et al.   NEUROBIOLOGY OF DISEASE

Depletion of NK Cells Improves Cognitive Function in the Alzheimer Disease Mouse Model

(2020) Yuanyue Zhang et al.   JOURNAL OF IMMUNOLOGY

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis

(2020) Tobias Granberg et al.   JOURNAL OF NEUROLOGY

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

(2020) Michael P. O’Donnell et al.   NATURE

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

(2020) Kalil Alves de Lima et al.   NATURE IMMUNOLOGY

A new neutrophil subset promotes CNS neuron survival and axon regeneration

(2020) Andrew R. Sas et al.   NATURE IMMUNOLOGY

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

(2020) Mattia Gallizioli et al.   Cell Reports

Transcriptomic and clonal characterization of T cells in the human central nervous system

(2020) Jenna L. Pappalardo et al.   Science Immunology

Sympathetic nervous tone limits the development of myeloid-derived suppressor cells

(2020) James T. Nevin et al.   Science Immunology

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

(2020) Siyi Huang et al.   CELL

Nociceptive nerves regulate haematopoietic stem cell mobilization

(2020) Xin Gao et al.   NATURE

Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

(2020) Wei-Na Jin et al.   NATURE NEUROSCIENCE

Adrenergic regulation of immune cell function and inflammation

(2020) Drashya Sharma et al.   Seminars in Immunopathology

Neutrophils Return to Bloodstream Through the Brain Blood Vessel After Crosstalk With Microglia During LPS-Induced Neuroinflammation

(2020) Yu Rim Kim et al.   Frontiers in Cell and Developmental Biology

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

(2019) Neta Rosenzweig et al.   Nature Communications

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

(2019) A. Kertser et al.   Science Advances

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion

(2019) Amaia Otxoa-de-Amezaga et al.   STROKE

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Astrogliosis inhibition attenuates hydrocephalus by increasing cerebrospinal fluid reabsorption through the glymphatic system after germinal matrix hemorrhage

(2019) Yan Ding et al.   EXPERIMENTAL NEUROLOGY

B cells in autoimmune and neurodegenerative central nervous system diseases

(2019) Joseph J. Sabatino et al.   NATURE REVIEWS NEUROSCIENCE

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

(2019) Miguel Ribeiro et al.   Science Immunology

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Mass cytometry analysis of immune cells in the brain

(2018) Ben Korin et al.   Nature Protocols

Neuroinflammation: Microglia and T Cells Get Ready to Tango

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Glucocorticoids, Sex Hormones, and Immunity

(2018) Oxana Bereshchenko et al.   Frontiers in Immunology

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Protective and Pathological Immunity during Central Nervous System Infections

(2017) Robyn S. Klein et al.   IMMUNITY

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

(2017) Sangeeta S. Chavan et al.   IMMUNITY

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

(2017) Takashi Shichita et al.   NATURE MEDICINE

C1 neurons mediate a stress-induced anti-inflammatory reflex in mice

(2017) Chikara Abe et al.   NATURE NEUROSCIENCE

Mast cells in neuroinflammation and brain disorders

(2017) Erik Hendriksen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages

(2017) Wei Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke

(2017) Mathias Gelderblom et al.   STROKE

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Dendritic cells in brain diseases

(2016) Peter Ludewig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

(2016) Violeta Silva-Vargas et al.   Cell Stem Cell

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

(2016) Shinelle Menezes et al.   IMMUNITY

Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity

(2016) Abigail E. Russi et al.   JOURNAL OF AUTOIMMUNITY

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

How Do Meningeal Lymphatic Vessels Drain the CNS?

(2016) Daniel Raper et al.   TRENDS IN NEUROSCIENCES

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

(2016) Hyunjung Baek et al.   Oncotarget

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

(2015) Sandro Dá Mesquita et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood–brain barrier cells toward enhanced prostaglandin E2 signaling

(2015) Ana Maria Vasilache et al.   BRAIN BEHAVIOR AND IMMUNITY

DNGR-1+dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain

(2015) Elena Quintana et al.   GLIA

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Comprehensive Immunophenotyping of Cerebrospinal Fluid Cells in Patients with Neuroimmunological Diseases

(2014) S. Han et al.   JOURNAL OF IMMUNOLOGY

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

CNS-specific T cells shape brain function via the choroid plexus

(2013) Kuti Baruch et al.   BRAIN BEHAVIOR AND IMMUNITY

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

NK Cells in Central Nervous System Disorders

(2013) A. Poli et al.   JOURNAL OF IMMUNOLOGY

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2012) Massimo Costanza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

(2012) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain

(2012) Charlotte Schmitt et al.   Journal of Neuroinflammation

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Enriched CD161highCCR6+γδ T Cells in the Cerebrospinal Fluid of Patients With Multiple Sclerosis

(2012) Lucas Schirmer et al.   JAMA Neurology

TLR7 and TLR9 Trigger Distinct Neuroinflammatory Responses in the CNS

(2011) Niranjan B. Butchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab

(2011) H. L. Pellkofer et al.   NEUROLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation

(2010) Junwei Hao et al.   ANNALS OF NEUROLOGY

Central memory CD4+ T cells dominate the normal cerebrospinal fluid

(2010) Marieke T. de Graaf et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary lymphoid organs in female Fischer 344 rats

(2010) Srinivasan ThyagaRajan et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Accumulation of resident and peripheral dendritic cells in the aging CNS

(2010) Ulrike W. Kaunzner et al.   NEUROBIOLOGY OF AGING

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

(2010) K. Thanopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats

(2009) Karine Palin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Reducing post-traumatic anxiety by immunization

(2008) Gil M. Lewitus et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

(2008) Asya Rolls et al.   PLOS MEDICINE