Immune cell compartmentalization for brain surveillance and protection

Schwartz and colleagues review the immune niches in the brain, the contribution of professional immune cells to brain functions and the relevance of immune components to brain aging and neurodegenerative disease. For decades, it was commonly accepted that the brain is secluded from peripheral immune activity and is self-sufficient for its maintenance and repair. This simplistic perception was based on the presence of resident immune cells, the microglia, and barrier systems within the brain, and the assumption that the central nervous system (CNS) lacks lymphatic drainage. This view was revised with the discoveries that higher functions of the CNS, homeostasis and repair are supported by peripheral innate and adaptive immune cells. The findings of bone marrow-derived immune cells in specialized niches, and the renewed observation that a lymphatic drainage system exists within the brain, further contributed to this revised model. In this Review, we describe the immune niches within the brain, the contribution of professional immune cells to brain functions, the bidirectional relationships between the CNS and the immune system and the relevance of immune components to brain aging and neurodegenerative diseases.

Automated summary

The brain is not completely isolated from external immune activity, with microglia and a lymphatic drainage system present within it. The discovery and study of peripheral immune cells have proposed a new understanding of the immune function in the brain.