Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice

Abrogation of type-I interferon signalling alters the microglial response to Aβ1–42

(2020) Zachery Moore et al.   Scientific Reports

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

(2020) Annerieke Sierksma et al.   SCIENCE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

(2019) Jing Tian et al.   Science Translational Medicine

Interferons: A molecular switch between damage and repair in ageing and Alzheimer’s disease

(2019) N. Gorlé et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress

(2019) Hila Ben-Yehuda et al.   MOLECULAR PSYCHIATRY

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

(2019) Diana K. Franco-Bocanegra et al.   Acta Neuropathologica Communications

Inflammasome-mediated innate immunity in Alzheimer’s disease

(2019) Carmen Venegas et al.   FASEB JOURNAL

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

The Role of Microglia in the Spread of Tau: Relevance for Tauopathies

(2018) Juan R. Perea et al.   Frontiers in Cellular Neuroscience

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia

(2018) Fiona C. Brown et al.   Cancer Discovery

Microglia have a more extensive and divergent response to interferon-α compared with astrocytes

(2018) Wen Li et al.   GLIA

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

(2017) Ruohe Zhao et al.   Molecular Neurodegeneration

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Myocyte enhancer factor 2C and its directly-interacting proteins: A review

(2017) Chen Dong et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease

(2017) Tomoko Sao et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

MEF2C rs190982 polymorphism with late-onset Alzheimer’s disease in Han Chinese: A replication study and meta-analyses

(2016) Shan-Shan Tang et al.   Oncotarget

MEF2C and EBF1 Co-regulate B Cell-Specific Transcription

(2016) Nikki R. Kong et al.   PLoS Genetics

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

(2016) Adam J Harrington et al.   eLife

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

(2016) Myles R. Minter et al.   Acta Neuropathologica Communications

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

(2015) Sandro Dá Mesquita et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review

(2015) Manivannan Yegambaram et al.   Current Alzheimer Research

Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment

(2015) Ferenc Deak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

FunRich: An open access standalone functional enrichment and interaction network analysis tool

(2015) Mohashin Pathan et al.   PROTEOMICS

Type I interferonopathies—an expanding disease spectrum of immunodysregulation

(2015) Min Ae Lee-Kirsch et al.   Seminars in Immunopathology

Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

(2015) Courtney M Anderson et al.   Skeletal Muscle

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women

(2014) Rafael Velázquez-Cruz et al.   BMC MUSCULOSKELETAL DISORDERS

Quantitative assessment of microglial morphology and density reveals remarkable consistency in the distribution and morphology of cells within the healthy prefrontal cortex of the rat

(2014) Ratchaniporn Kongsui et al.   Journal of Neuroinflammation

Morphometric characterization of microglial phenotypes in human cerebral cortex

(2014) Susana G Torres-Platas et al.   Journal of Neuroinflammation

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

(2013) L. Zuurbier et al.   HAEMATOLOGICA

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

(2013) L. F. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Mef2cdeletion in osteocytes results in increased bone mass

(2011) Ina Kramer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE