PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

PD-1 immune checkpoint blockade promotes brain leukocyte infiltration and diminishes cyst burden in a mouse model of Toxoplasma infection

(2018) Jianchun Xiao et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

(2018) Samuel Frere et al.   NEURON

Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models

(2017) Martine Latta-Mahieu et al.   GLIA

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Can immunotherapy treat neurodegeneration?

(2017) Michal Schwartz   SCIENCE

A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies

(2017) Anfei Huang et al.   Scientific Reports

PD-1/PD-L1 blockade in cancer treatment: perspectives and issues

(2016) Junzo Hamanishi et al.   International Journal of Clinical Oncology

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease

(2016) Francesco Panza et al.   Biomed Research International

The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

(2016) Kankana Bardhan et al.   Frontiers in Immunology

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

(2015) Sandro Dá Mesquita et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

(2015) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

Migration of Bone Marrow-Derived Cells Into the Central Nervous System in Models of Neurodegeneration

(2015) Antoine Lampron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

(2014) Michal Schwartz et al.   JOURNAL OF AUTOIMMUNITY

Modulation of inflammation in transgenic models of Alzheimer’s disease

(2014) Amy M Birch et al.   Journal of Neuroinflammation

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease

(2013) Gaëlle Naert et al.   Journal of Molecular Cell Biology

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Alzheimer's Disease 2012

(2012) Vincent T. Marchesi   AMERICAN JOURNAL OF PATHOLOGY

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cells Support Homeostatic Expansion of Foxp3 + Regulatory T Cells in Foxp3.LuciDTR Mice

(2010) Janine Suffner et al.   JOURNAL OF IMMUNOLOGY

Macrophages in Alzheimer’s disease: the blood-borne identity

(2010) David Gate et al.   JOURNAL OF NEURAL TRANSMISSION

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9

(2009) Maya Koronyo-Hamaoui et al.   JOURNAL OF NEUROCHEMISTRY

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

(2008) Hanna Rosenmann et al.   EXPERIMENTAL NEUROLOGY

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation