SCD1, autophagy and cancer: implications for therapy

Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration

(2021) Sathyanarayanan Ranganayaki et al.   Scientific Reports

TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues

(2021) Áron Bartha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

(2020) Martina Di Rienzo et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in animal development

(2020) Elizabeth A. Allen et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and microbial pathogenesis

(2020) Matthew D. Keller et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and disease: unanswered questions

(2020) Ying Yang et al.   CELL DEATH AND DIFFERENTIATION

Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II

(2020) Keli Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

(2020) Leilei Zhang et al.   Cell Death & Disease

KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden

(2020) D. Marinelli et al.   ANNALS OF ONCOLOGY

Drug tolerance to target therapy in melanoma revealed at single cell level: What next?

(2020) Domenico Liguoro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

(2020) Corrin A. Wohlhieter et al.   Cell Reports

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death

(2019) Jurgen Kriel et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic modulation of autophagy: which disease comes first?

(2019) Maria Chiara Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and cardiac aging

(2019) Shigeki Miyamoto   CELL DEATH AND DIFFERENTIATION

Autophagy in endothelial cells and tumor angiogenesis

(2019) Marco B. Schaaf et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

(2019) Kelin She et al.   Cancer Cell International

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer

(2019) Zuzanna Tracz-Gaszewska et al.   Cancers

Lipid metabolism offers anticancer treatment by regulating ferroptosis

(2019) Michele Carbone et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Emerging Roles of Lipophagy in Health and Disease

(2019) Konstantinos Kounakis et al.   Frontiers in Cell and Developmental Biology

Phosphoinositides in autophagy: current roles and future insights

(2019) Lavinia Palamiuc et al.   FEBS Journal

Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization

(2019) Marta Pérez-Hernández et al.   Cancers

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

(2019) Maximilian Schütter et al.   CELL

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

(2019) Jean M. Mulcahy Levy et al.   CELL DEATH AND DIFFERENTIATION

N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

(2019) Hongsheng Wang et al.   Molecular Cancer

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN

(2018) Hui Ran et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

(2018) Sarah E. Winterton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells

(2018) Guanghua Liu et al.   ONCOGENE

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

(2018) Weihua Li et al.   Oncotarget

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

(2018) Lan Thi Hanh Phi et al.   Stem Cells International

Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver

(2018) Sabrina N. Dumas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation

(2018) Wenjiao Li et al.   CELL DEATH AND DIFFERENTIATION

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway

(2018) Lu-Yu Zhou et al.   CELL DEATH AND DIFFERENTIATION

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

(2018) Marion Orsini et al.   CELL DEATH AND DIFFERENTIATION

Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate

(2018) Simon Ducheix et al.   GASTROENTEROLOGY

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer

(2018) Chiyuan Piao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

(2018) Maria Elena Pisanu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation

(2017) Thomas Riffelmacher et al.   IMMUNITY

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

(2017) A Noto et al.   ONCOGENE

Exogenous lipids promote the growth of breast cancer cells via CD36

(2017) Jing Zhao et al.   ONCOLOGY REPORTS

Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

(2017) Akito Ono et al.   PLoS One

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

(2017) Vito W. Rebecca et al.   Cancer Discovery

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

(2016) Rohit Anthony Sinha et al.   Autophagy

Autophagic homeostasis is required for the pluripotency of cancer stem cells

(2016) Tanveer Sharif et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

(2016) Panayotis C Theodoropoulos et al.   Nature Chemical Biology

Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes

(2016) Sergio Rodriguez-Cuenca et al.   PLoS One

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

(2015) Guang-Ming Huang et al.   CANCER LETTERS

Unsaturated fatty acids induce non-canonical autophagy

(2015) M. Niso-Santano et al.   EMBO JOURNAL

Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

(2015) Christina A. von Roemeling et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

(2015) Justyna Janikiewicz et al.   JOURNAL OF LIPID RESEARCH

X-ray structure of a mammalian stearoyl-CoA desaturase

(2015) Yonghong Bai et al.   NATURE

Stearoyl-CoA Desaturase 1 Activity Is Required for Autophagosome Formation

(2014) Yuta Ogasawara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

(2013) Yuan-Fei Peng et al.   Autophagy

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy

(2013) Y H Jang et al.   CELL DEATH AND DIFFERENTIATION

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes

(2013) Anuradha Budhu et al.   GASTROENTEROLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

(2013) Josef G. Meingassner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease

(2013) Zaihui Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma

(2013) Samiksha Bansal et al.   JOURNAL OF SURGICAL RESEARCH

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

(2013) A Noto et al.   Cell Death & Disease

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

EMT markers in lung adenocarcinoma pleural effusion spheroid cells

(2012) Enrico Giarnieri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FATTY ACIDS AS BIOCOMPOUNDS: THEIR ROLE IN HUMAN METABOLISM, HEALTH AND DISEASE - A REVIEW. PART 1: CLASSIFICATION, DIETARY SOURCES AND BIOLOGICAL FUNCTIONS

(2011) Eva Tvrzicka et al.   BIOMEDICAL PAPERS-OLOMOUC

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy positively regulates the CD44+CD24-/lowbreast cancer stem-like phenotype

(2011) Sílvia Cufí et al.   CELL CYCLE

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Impaired OXPHOS Complex III in Breast Cancer

(2011) Kjerstin M. Owens et al.   PLoS One

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

(2010) Koji Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oleate and linoleate stimulate degradation of β-casein in prolactin-treated HC11 mouse mammary epithelial cells

(2010) Alain Pauloin et al.   CELL AND TISSUE RESEARCH

Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death

(2010) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Oxidized low-density lipoprotein (oxLDL) induces cell death in neuroblastoma and survival autophagy in schwannoma cells

(2010) Marcin Nowicki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells

(2010) Daniel Hess et al.   PLoS One

A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila

(2009) Katja Köhler et al.   Autophagy

Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?

(2009) Christopher J Nolan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia

(2008) Rebecca Mar-Heyming et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY