TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Nucleophagy: from homeostasis to disease

(2019) Margarita-Elena Papandreou et al.   CELL DEATH AND DIFFERENTIATION

TRIM proteins

(2019) Milica Vunjak et al.   CURRENT BIOLOGY

Emerging Roles of the TRIM E3 Ubiquitin Ligases MID1 and MID2 in Cytokinesis

(2019) Melania Eva Zanchetta et al.   Frontiers in Physiology

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

(2019) M. Di Rienzo et al.   Science Advances

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

A TRIM32-AMBRA1-ULK1 complex initiates the autophagy response in atrophic muscle cells

(2019) Martina Di Rienzo et al.   Autophagy

Cell death–mediated cytokine release and its therapeutic implications

(2019) David E. Place et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy

(2019) Xing Liu et al.   JOURNAL OF VIROLOGY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Restriction of HIV-1 and other retroviruses by TRIM5

(2019) Barbie K. Ganser-Pornillos et al.   NATURE REVIEWS MICROBIOLOGY

Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

(2019) Xufeng Pan et al.   Cell Death & Disease

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

The Pyrin Inflammasome in Health and Disease

(2019) Oskar Schnappauf et al.   Frontiers in Immunology

ER-phagy and human diseases

(2019) Christian A. Hübner et al.   CELL DEATH AND DIFFERENTIATION

TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1

(2019) Katrine Stange Overå et al.   JOURNAL OF CELL SCIENCE

Selective Autophagy Receptors in Neuronal Health and Disease

(2019) Owen Conway et al.   JOURNAL OF MOLECULAR BIOLOGY

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

(2019) Søs Grønbæk Holdgaard et al.   Nature Communications

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis

(2018) Wei Wang et al.   Autophagy

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

TRIM50 regulates Beclin 1 proautophagic activity

(2018) Carmela Fusco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

(2018) Sachet A. Shukla et al.   CELL

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

TRIM22 regulates macrophage autophagy and enhances Mycobacterium tuberculosis clearance by targeting the nuclear factor-multiplicity κB/beclin 1 pathway

(2018) Jun Lou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of autophagy in IL-1β export and release from cells

(2018) Aurore Claude-Taupin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

(2018) Cynthia Louis et al.   Frontiers in Immunology

Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

(2018) Deyan Chen et al.   Frontiers in Immunology

TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1

(2018) Tianyu Han et al.   Autophagy

TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

(2018) Kautilya Kumar Jena et al.   EMBO JOURNAL

Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis

(2018) Claudia Morganti et al.   INTERNATIONAL JOURNAL OF OBESITY

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism

(2018) Benjamin Brigant et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

TRIM21 and the Function of Antibodies inside Cells

(2017) David A. Rhodes et al.   TRENDS IN IMMUNOLOGY

Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis

(2017) Liang Chen et al.   Cell Reports

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation

(2016) Michael A. Mandell et al.   JOURNAL OF CELL SCIENCE

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

(2016) Mitchell S. Wold et al.   Molecular Neurodegeneration

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

(2016) Carla M. S. Ribeiro et al.   NATURE

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

(2016) Sonia Missiroli et al.   Cell Reports

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

(2015) Carlos T. Pineda et al.   CELL

PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection

(2015) David G. McEwan et al.   Cell Host & Microbe

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

TRIM-NHL proteins in development and disease

(2015) Cristina Tocchini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

(2014) Liang Ge et al.   eLife

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

(2013) Muzamil Majid Khan et al.   Autophagy

SnapShot: Selective Autophagy

(2013) Meiyan Jin et al.   CELL

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

(2013) I. Barde et al.   SCIENCE

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Molecular mechanisms of selective autophagy

(2012) G M Fimia et al.   CELL DEATH AND DIFFERENTIATION

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

(2011) Luisa M. Napolitano et al.   BIOCHEMICAL JOURNAL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation

(2011) Luisa M. Napolitano et al.   IUBMB LIFE

Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

(2011) Pierre Boudinot et al.   PLoS One

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

(2011) Kyudong Han et al.   PLoS Genetics

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

(2009) Lieke M van der Aa et al.   BMC BIOLOGY