Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

Hypoxia and heat stress affect epithelial integrity in a Caco-2/HT-29 co-culture

(2021) Puqiao Lian et al.   Scientific Reports

Proteomic analysis of desmosomes reveals novel components required for epidermal integrity

(2020) Kwabena A. Badu-Nkansah et al.   MOLECULAR BIOLOGY OF THE CELL

The Urothelium: Life in a Liquid Environment

(2020) Marianela G. Dalghi et al.   PHYSIOLOGICAL REVIEWS

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions

(2020) Benedict Tan et al.   CURRENT BIOLOGY

Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics

(2020) Florian Rouaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Composition of hemidesmosomes in basal keratinocytes of normal buccal mucosa and oral lichen planus

(2020) Olav Schreurs et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Tight Junction Structure and Function Revisited

(2020) Tetsuhisa Otani et al.   TRENDS IN CELL BIOLOGY

Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth

(2019) Herve Alégot et al.   JOURNAL OF CELL SCIENCE

Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

(2019) Yin-Fang Wu et al.   Autophagy

CLDN1 induces autophagy to promote proliferation and metastasis of esophageal squamous carcinoma through AMPK/STAT1/ULK1 signaling

(2019) Jian Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy

(2019) Peiye Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

(2019) Antonio Totaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development

(2019) Rui Miao et al.   DEVELOPMENTAL CELL

New insights into transcriptional reprogramming during cellular stress

(2019) Samu V. Himanen et al.   JOURNAL OF CELL SCIENCE

Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

(2019) Andreas Herrmann et al.   ONCOGENE

The Heat Shock Response in Yeast Maintains Protein Homeostasis by Chaperoning and Replenishing Proteins

(2019) Moritz Mühlhofer et al.   Cell Reports

Autophagy-mediated upregulation of cytoplasmic claudin 1 stimulates the degradation of SQSTM1/p62 under starvation

(2018) Jaewhan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tension-dependent regulation of mammalian Hippo signaling through LIMD1

(2018) Consuelo Ibar et al.   JOURNAL OF CELL SCIENCE

Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

(2018) Beiyun Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Galectin-8 induces partial epithelial–mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin–Darby canine kidney cells

(2018) Claudia Oyanadel et al.   MOLECULAR BIOLOGY OF THE CELL

BP180 dysfunction triggers spontaneous skin inflammation in mice

(2018) Yang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-9 Alters Epithelial Barrier and E-cadherin in Eosinophilic Esophagitis

(2018) Ashmi Doshi et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

(2018) Mariana Pavel et al.   Nature Communications

Involvement of the Prion Protein in the Protection of the Human Bronchial Epithelial Barrier against Oxidative Stress

(2018) Amal Kouadri et al.   ANTIOXIDANTS & REDOX SIGNALING

Assembly of the β4-integrin interactome based on proximal biotinylation in the presence and absence of heterodimerization

(2018) Satu-Marja Myllymäki et al.   MOLECULAR & CELLULAR PROTEOMICS

Keratin 6a reorganization for ubiquitin–proteasomal processing is a direct antimicrobial response

(2017) Jonathan K.L. Chan et al.   JOURNAL OF CELL BIOLOGY

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion

(2017) Ariadne Vlahakis et al.   JOURNAL OF MOLECULAR BIOLOGY

Cell–Cell Junctions Organize Structural and Signaling Networks

(2017) Miguel A. Garcia et al.   Cold Spring Harbor Perspectives in Biology

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

(2017) Matthias Rübsam et al.   Nature Communications

TRPV4 channels in the human urogenital tract play a role in cell junction formation and epithelial barrier

(2016) D.A.W. Janssen et al.   Acta Physiologica

Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling

(2016) Xing-Ding Zhang et al.   CANCER CELL

Hemidesmosome integrity protects the colon against colitis and colorectal cancer

(2016) Adèle De Arcangelis et al.   GUT

Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture

(2016) Danielle M. Jorgens et al.   JOURNAL OF CELL SCIENCE

Gastrointestinal mucosal barrier function and diseases

(2016) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

(2016) M Gugnoni et al.   ONCOGENE

Structural Damage in the C. elegans Epidermis Causes Release of STA-2 and Induction of an Innate Immune Response

(2015) Yun Zhang et al.   IMMUNITY

Tight junction disruption:Helicobacter pyloriand dysregulation of the gastric mucosal barrier

(2015) Tyler J Caron   WORLD JOURNAL OF GASTROENTEROLOGY

Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells

(2015) Ying Qu et al.   PLoS One

Blistering disease: insight from the hemidesmosome and other components of the dermal-epidermal junction

(2014) Iana Turcan et al.   CELL AND TISSUE RESEARCH

α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling

(2014) Hai-long Piao et al.   NATURE CELL BIOLOGY

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

(2014) N. A. Baird et al.   SCIENCE

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

(2014) Z. Guo et al.   Science Signaling

Integrin-linked kinase modulates longevity and thermotolerance inC. elegansthrough neuronal control of HSF-1

(2013) Caroline Kumsta et al.   AGING CELL

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

(2013) Nan Chen et al.   Autophagy

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

The N and C Termini of ZO-1 Are Surrounded by Distinct Proteins and Functional Protein Networks

(2013) Christina M. Van Itallie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

(2013) Robert M. Harmon et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for anti-BP180 autoantibodies in chronic rhinosinusitis

(2013) Jill S. Jeffe et al.   LARYNGOSCOPE

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

(2013) Liat Samuelov et al.   NATURE GENETICS

Keratin 16 regulates innate immunity in response to epidermal barrier breach

(2013) J. C. Lessard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desmosome assembly and dynamics

(2013) Oxana Nekrasova et al.   TRENDS IN CELL BIOLOGY

Relevance of Ultrastructural Alterations of Intercellular Junction Morphology in Inflamed Human Esophagus

(2013) Chia-Chin Liu et al.   Journal of Neurogastroenterology and Motility

Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair

(2013) Susan B. Hopkinson et al.   Advances in Wound Care

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling

(2012) K Brennan et al.   ONCOGENE

Effects of Ethanol and Acetaldehyde on Tight Junction Integrity: In Vitro Study in a Three Dimensional Intestinal Epithelial Cell Culture Model

(2012) Elhaseen Elamin et al.   PLoS One

Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival

(2012) M. Nie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles

(2012) Andrew D. Chisholm et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Dissecting the Genetics of Complex Inheritance: Linkage Disequilibrium Mapping Provides Insight into Crohn Disease

(2011) Heather Elding et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins

(2011) Marisa Ponpuak et al.   Autophagy

The MDCK variety pack: choosing the right strain

(2011) Joseph D Dukes et al.   BMC CELL BIOLOGY

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

The Mechanoreceptor TRPV4 is Localized in Adherence Junctions of the Human Bladder Urothelium: A Morphological Study

(2011) Dick A.W. Janssen et al.   JOURNAL OF UROLOGY

Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation

(2011) Liwei Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin

(2011) Andrew L. Smith et al.   MOLECULAR BIOLOGY OF THE CELL

Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties

(2011) Z Huang et al.   ONCOGENE

The making of hemidesmosome structures in vivo

(2010) Huimin Zhang et al.   DEVELOPMENTAL DYNAMICS

Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation

(2010) Cristina Niculescu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Dynamic Relationship of Focal Contacts and Hemidesmosome Protein Complexes in Live Cells

(2010) Toshiyuki Ozawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

(2010) F E Lock et al.   ONCOGENE

fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation

(2009) Peter F. Truesdell et al.   EXPERIMENTAL CELL RESEARCH

The Desmosome

(2009) E. Delva et al.   Cold Spring Harbor Perspectives in Biology

Adherens Junction: Molecular Architecture and Regulation

(2009) W. Meng et al.   Cold Spring Harbor Perspectives in Biology

Molecular Basis of the Core Structure of Tight Junctions

(2009) M. Furuse   Cold Spring Harbor Perspectives in Biology

Cellular and Molecular Mechanisms of Heat Stress-Induced Up-Regulation of Occludin Protein Expression

(2008) Karol Dokladny et al.   AMERICAN JOURNAL OF PATHOLOGY

Tight junction-based epithelial microenvironment and cell proliferation

(2008) S Tsukita et al.   ONCOGENE

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer

(2008) M. Perez-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

(2008) Atsuko Fukazawa et al.   PLoS Pathogens

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL