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Biochemistry & Molecular Biology
Ravi, Ajay Kumar, Shalmoli Bhattacharyya, Jogender Singh
Summary: Thiol antioxidants can modulate cellular physiology and activate the hypoxia response pathway, possibly through the production of hydrogen sulfide.
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Developmental Biology
Simon Berger, Silvan Spiri, Andrew DeMello, Alex Hajnal
Summary: A novel microfluidic imaging method has been introduced to allow parallel live-imaging across multiple larval stages of Caenorhabditis elegans while maintaining worm orientation and identity. The method ensures stable worm orientation and viability, showcasing capabilities such as observing hypodermal seam and P-cell divisions, as well as the entire process of vulval development, and demonstrating feasibility of on-chip RNAi.
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Cell Biology
Khairun Nisaa, Anat Ben-Zvi
Summary: Muscle proteostasis is regulated by the myogenic transcription factor MyoD. This study demonstrates that MyoD can modulate chaperone expression in terminally differentiated muscle cells, indicating its role in muscle maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
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Multidisciplinary Sciences
Olga Filina, Burak Demirbas, Rik Haagmans, Jeroen S. van Zon
Summary: Maintaining the correct temporal order of cellular events is crucial for animal development. In this study, researchers used time-lapse microscopy to examine the timing of gene expression, cell divisions, and cuticle shedding in individual Caenorhabditis elegans larvae. They found that there was variability in timing between individuals, but this variability followed temporal scaling. Changes in temperature, diet, or genotype also influenced timing, but still adhered to temporal scaling. However, shifting conditions during development disrupted temporal scaling and changed event order in a condition-specific manner.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
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Immunology
Jinlong Wan, Lei Yuan, Huiru Jing, Qian Zheng, Hui Xiao
Summary: Clearance of apoptotic cells is crucial for multicellular organisms and tissue homeostasis. In C. elegans, defects in apoptotic cell clearance can protect the worms from bacterial infection by activating the innate immune response.
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Biochemistry & Molecular Biology
Srijit Das, Sehee Min, Veena Prahlad
Summary: Maternal stress can trigger long-lasting epigenetic effects on offspring through the activation of the heat shock transcription factor HSF-1 in the germline of Caenorhabditis elegans. This leads to a heritable epigenetic memory of stress exposure in the next generation, shifting their stress response strategy towards decreased insulin/IGF-1-like signaling.
Article
Neurosciences
Tatsuhiro Shimizu, Kayoko Sugiura, Yoshiki Sakai, Abdul R. Dar, Rebecca A. Butcher, Kunihiro Matsumoto, Naoki Hisamoto
Summary: Chemical communication plays a crucial role in axon regeneration, and the ascaroside signaling system serves as a unique example of regulating the regenerative pathway in the nervous system.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Anatomy & Morphology
Miriam B. Goodman, Cathy Savage-Dunn
Summary: Studying TGF-beta signaling and the extracellular matrix in C. elegans has revealed unexpected connections between signaling and ECM, providing new insights into the interactions across tissues and spatial scales.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Neurosciences
Naoki Hisamoto, Yoshiki Sakai, Kohei Ohta, Tatsuhiro Shimizu, Chun Li, Hiroshi Hanafusa, Kunihiro Matsumoto
Summary: This study reveals that CDK14 activates the RhoGEF-CDC42-MLC phosphorylation axis in a noncanonical Wnt signaling pathway to promote axon regeneration in Caenorhabditis elegans. The results suggest a novel regulatory mechanism for neuronal regeneration and provide new insights into the molecular mechanisms underlying axon regeneration.
JOURNAL OF NEUROSCIENCE
(2021)
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Pharmacology & Pharmacy
Kanglu Wu, Xudong Zhao, Xian Xiao, Miao Chen, Liang Wu, Chao Jiang, Jing Jin, Lei Li, Qinli Ruan, Jun Guo
Summary: This study demonstrated that BuShen HuoXue (BSHX) decoction can potentially improve fertility by increasing intestinal barrier function via the hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans. BSHX decoction improved resistance to heat stress and reversed the adverse effects induced by Bisphenol A, significantly improving brood size and oocyte quality at different developmental stages. These findings contribute to a better understanding of the underlying regulatory mechanisms of heat resistance against fertility defects mediated by hsp-16.2.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Kelsey Michelle Wells, Kai He, Aseem Pandey, Ana Cabello, Dongmei Zhang, Jing Yang, Gabriel Gomez, Yue Liu, Haowu Chang, Xueqiang Li, Hao Zhang, Xuehuang Feng, Luciana Fachini da Costa, Richard Metz, Charles D. Johnson, Cameron Lee Martin, Jill Skrobarczyk, Luc R. Berghman, Kristin L. Patrick, Julian Leibowitz, Allison Ficht, Sing-Hoi Sze, Jianxun Song, Xiaoning Qian, Qing-Ming Qin, Thomas A. Ficht, Paul de Figueiredo
Summary: This study revealed a novel immune defense factor, BLOS1, whose activity is exploited by diverse pathogens like Brucella and coronavirus to promote intracellular parasitism or replication.
Article
Multidisciplinary Sciences
Hongfei Ji, Anthony D. Fouad, Zihao Li, Andrew Ruba, Christopher Fang-Yen
Summary: This study describes the proprioception-mediated homeostatic control of undulatory movement in C. elegans. The worm responds to decreases in midbody bending amplitude by increasing anterior amplitude and vice versa. The neural circuit underlying this compensatory postural response involves dopamine signaling from PDE neurons to AVK interneurons, which release FLP-1 to regulate SMB head motor neurons for anterior bending. This homeostatic control optimizes locomotor efficiency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
Haiyan Chen, Rongji Li, Feng Zhao, Li Luan, Tiantian Han, Zhong Li
Summary: Studies have shown that betulinic acid (BA), a natural product derived from birch bark, has beneficial effects on the lifespan and stress resistance of Caenorhabditis elegans. The optimal dose of BA extended the lifespan, improved the healthspan, and increased oxidative stress resistance in C. elegans. The protective effects of BA on lifespan and antioxidant activity were mediated by the downstream effector DAF-16, which is part of the insulin/IGF-1 receptor signaling pathway.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Biochemistry & Molecular Biology
Rebecca K. Lau, Eray Enustun, Yajie Gu, Justin Nguyen, Kevin D. Corbett
Summary: Bacteria have evolved diverse immune systems to protect themselves from phage infection. Researchers have discovered a transcriptional regulator module associated with hundreds of CBASS immune systems and demonstrated its role in driving the expression of the CBASS system in response to DNA damage. This finding highlights a mechanism by which bacterial immune systems can sense and respond to cellular stress.
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Cell Biology
Shiya Cheng, Kun Wang, Wei Zou, Rui Miao, Yaling Huang, Haibin Wang, Xiaochen Wang
JOURNAL OF CELL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Zengzhang Zheng, Wanyan Deng, Yang Bai, Rui Miao, Shenglin Mei, Zhibin Zhang, Youdong Pan, Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman, Xing Liu
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Biochemistry & Molecular Biology
Karla F. Meza-Sosa, Rui Miao, Francisco Navarro, Zhibin Zhang, Ying Zhang, Jun Jacob Hu, Corrine Corrina R. Hartford, Xiao Ling Li, Gustavo Pedraza-Alva, Leonor Perez-Martinez, Ashish Lal, Hao Wu, Judy Lieberman
Summary: The p53-induced lncRNA SPARCLE enhances p53-mediated apoptosis by promoting PARP-1 cleavage, leading to interference with DNA damage repair.
Article
Thermodynamics
Yao Yu, Ahmed C. Megri, Rui Miao, Xiaoou Hu
Summary: Atriums in modern building designs pose challenges related to energy and airflow distribution, and this study introduces a new dynamic zonal model (DOMA) to predict airflow and temperature stratification. The model is calibrated using the SCE-UA method and recommends using two K-values for improved accuracy and quality. This research highlights the limitations and potential improvements of the zonal modeling approach.
SCIENCE AND TECHNOLOGY FOR THE BUILT ENVIRONMENT
(2022)
