Galectin-8 induces partial epithelial–mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin–Darby canine kidney cells

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

(2016) Asoka Banno et al.   Oncotarget

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

(2015) Valerie R Wiersma et al.   Autophagy

Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients

(2015) Jaime A Espinoza et al.   HISTOPATHOLOGY

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

(2015) James F Sampson et al.   IMMUNOLOGY AND CELL BIOLOGY

The galectin lattice at a glance

(2015) I. R. Nabi et al.   JOURNAL OF CELL SCIENCE

Galectin-1 Triggers Epithelial-Mesenchymal Transition in Human Hepatocellular Carcinoma Cells

(2015) María L. Bacigalupo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest

(2015) KIYOYUKI KOBAYASHI et al.   ONCOLOGY REPORTS

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

(2015) LaTonia Taliaferro-Smith et al.   Oncotarget

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

(2015) Vignesh Sundararajan et al.   Oncotarget

YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment

(2015) Shashi K. Gopal et al.   Oncotarget

The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

(2015) Yaron Vinik et al.   eLife

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer

(2014) Ronan Shaughnessy et al.   FEBS Journal

Galectin-8: A matricellular lectin with key roles in angiogenesis

(2014) M. F. Troncoso et al.   GLYCOBIOLOGY

Galectin-4-mediated transcytosis of transferrin receptor

(2014) Andres E. Perez Bay et al.   JOURNAL OF CELL SCIENCE

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

(2014) Izabela Mlynarczuk-Bialy et al.   Translational Oncology

Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13

(2014) Yinghai Ye et al.   TUMOR BIOLOGY

Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins

(2013) Andra Rizqiawan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients

(2013) Lucas Vicuña et al.   BIOLOGICAL RESEARCH

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

(2013) Steven M. Frisch et al.   JOURNAL OF CELL SCIENCE

Galectin-3– and phospho-caveolin-1–dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cells

(2013) Cecile Boscher et al.   MOLECULAR BIOLOGY OF THE CELL

Galectin-3 Accelerates the Progression of Oral Tongue Squamous Cell Carcinoma via a Wnt/β-catenin-Dependent Pathway

(2013) Li-Ping Wang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

Early events in cell adhesion and polarity during epithelial-mesenchymal transition

(2012) R. Y.-J. Huang et al.   JOURNAL OF CELL SCIENCE

Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9–dependent mechanism

(2012) Di Mo et al.   MOLECULAR BIOLOGY OF THE CELL

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Transformation of human ovarian surface epithelial cells by Krüppel-like factor 8

(2012) H Lu et al.   ONCOGENE

Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer

(2012) Ioannis A. Voutsadakis   TUMOR BIOLOGY

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

(2012) Nathan E. Reticker-Flynn et al.   Nature Communications

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

(2011) Gang Liu et al.   EMBO JOURNAL

Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans

(2011) Hiroko Ideo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8

(2010) Víctor M. Cárdenas Delgado et al.   FASEB JOURNAL

Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression

(2010) Jin Young Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Combined proteasome and histone deacetylase inhibition attenuates epithelial–mesenchymal transition through E-cadherin in esophageal cancer cells

(2010) Matthew D. Taylor et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation

(2010) Svenja Meierjohann et al.   Molecular Cancer

SRC-3Δ4 Mediates the Interaction of EGFR with FAK to Promote Cell Migration

(2010) Weiwen Long et al.   MOLECULAR CELL

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation

(2009) Andrés Norambuena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction

(2009) S Baritaki et al.   ONCOGENE

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells

(2008) Clotilde Billottet et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The epithelial polarity program: machineries involved and their hijacking by cancer

(2008) B Tanos et al.   ONCOGENE