Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes

(2012) Ming Shi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SHOC2 and CRAF Mediate ERK1/2 Reactivation in Mutant NRAS-mediated Resistance to RAF Inhibitor

(2012) Fred M. Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions

(2012) Jing Chen et al.   JOURNAL OF CELL BIOLOGY

Shoc2 Is Targeted to Late Endosomes and Required for Erk1/2 Activation in EGF-Stimulated Cells

(2012) Emilia Galperin et al.   PLoS One

Cardio-facio-cutaneous syndrome: Does genotype predict phenotype?

(2011) Judith E. Allanson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing

(2011) Gangwen Han et al.   AMERICAN JOURNAL OF PATHOLOGY

Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development

(2011) D.H. Siegel et al.   BRITISH JOURNAL OF DERMATOLOGY

Clinical manifestations of mutations in RAS and related intracellular signal transduction factors

(2011) Martin Zenker   CURRENT OPINION IN PEDIATRICS

ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

(2011) G. Sflomos et al.   JOURNAL OF CELL SCIENCE

Plakoglobin Rescues Adhesive Defects Induced by Ectodomain Truncation of the Desmosomal Cadherin Desmoglein 1

(2010) Cory L. Simpson et al.   AMERICAN JOURNAL OF PATHOLOGY

Desmosomes: adhesive strength and signalling in health and disease

(2010) Helen A. Thomason et al.   BIOCHEMICAL JOURNAL

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

(2010) Rie Matsunaga-Udagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies

(2010) Shoko Komatsuzaki et al.   JOURNAL OF HUMAN GENETICS

Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3

(2010) Jean M. Jennings et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ligand Targeting of EphA2 Enhances Keratinocyte Adhesion and Differentiation via Desmoglein 1

(2010) Samantha Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

(2010) Sayaka Yoshiki et al.   MOLECULAR BIOLOGY OF THE CELL

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Sur8/Shoc2 Involves Both Inhibition of Differentiation and Maintenance of Self-Renewal of Neural Progenitor Cells via Modulation of Extracellular Signal-Regulated Kinase Signaling

(2010) Byoung-San Moon et al.   STEM CELLS

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

(2009) Katherine A. Rauen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mutation inDSG1causing autosomal dominant striate palmoplantar keratoderma

(2009) M. Zamiri et al.   BRITISH JOURNAL OF DERMATOLOGY

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

(2009) Mark C. Wilkes et al.   DEVELOPMENTAL CELL

Compartmentalized signalling: Ras proteins and signalling nanoclusters

(2009) Jasminka Omerovic et al.   FEBS Journal

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes

(2009) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Mutations in the desmoglein 1 gene in five Pakistani families with striate palmoplantar keratoderma

(2009) Martha B. Dua-Awereh et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Differential expression of phosphorylated extracellular signal-regulated kinase 1/2, phosphorylated p38 mitogen-activated protein kinase and nuclear factor-κB p105/p50 in chronic inflammatory skin diseases

(2009) Shuang WANG et al.   JOURNAL OF DERMATOLOGY

An Extensive Survey of Tyrosine Phosphorylation Revealing New Sites in Human Mammary Epithelial Cells

(2009) Tyler H. Heibeck et al.   JOURNAL OF PROTEOME RESEARCH

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

(2009) Viviana Cordeddu et al.   NATURE GENETICS

Erbin regulates NRG1 signaling and myelination

(2009) Y. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Novel mutations inDSG1causing striate palmoplantar keratoderma

(2008) D. Hershkovitz et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

The PDZ Protein Erbin Modulates β-Catenin-Dependent Transcription

(2008) A. Ress et al.   EUROPEAN SURGICAL RESEARCH

Noonan, Costello and cardio–facio–cutaneous syndromes: dysregulation of the Ras–MAPK pathway

(2008) William E. Tidyman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Palmitoylation of ERBIN is required for its plasma membrane localization

(2008) Ichiro Izawa et al.   GENES TO CELLS

The Classical Nuclear Localization Signal Receptor, Importin- , Is Required for Efficient Transition Through the G1/S Stage of the Cell Cycle in Saccharomyces cerevisiae

(2008) K. F. Pulliam et al.   GENETICS

Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers

(2008) Olivera Stojadinovic et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes

(2008) Alix Gazel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation

(2008) Sylviane Lambert et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ADAM10-Mediated E-Cadherin Release Is Regulated by Proinflammatory Cytokines and Modulates Keratinocyte Cohesion in Eczematous Dermatitis

(2008) Thorsten Maretzky et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Outside-in Signaling through Integrins and Cadherins: A Central Mechanism to Control Epidermal Growth and Differentiation?

(2008) Eliane J. Müller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Disruption of Desmosome Assembly by Monovalent Human Pemphigus Vulgaris Monoclonal Antibodies

(2008) Xuming Mao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Desmoglein-Specific Cytoplasmic Region Is Intrinsically Disordered in Solution and Interacts with Multiple Desmosomal Protein Partners

(2008) Keiichiro Kami et al.   JOURNAL OF MOLECULAR BIOLOGY

Chronic wound state exacerbated by oxidative stress in Pax6+/− aniridia-related keratopathy

(2008) J Ou et al.   JOURNAL OF PATHOLOGY

Screening for EphB Signaling Effectors Using SILAC with a Linear Ion Trap-Orbitrap Mass Spectrometer

(2008) Guoan Zhang et al.   JOURNAL OF PROTEOME RESEARCH

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

(2008) Vihren Kolev et al.   NATURE CELL BIOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA