Article
Allergy
Shmulik Avlas, Guy Shani, Natalie Rhone, Michal Itan, Avishay Dolitzky, Inbal Hazut, Sharon Grisaru-Tal, Yaara Gordon, Tetsuo Shoda, Adina Ballaban, Netali Morgenstern Ben-Baruch, Mark Rochman, Yael Diesendruck, Limor Nahary, Almog Bitton, Zamir Halpern, Itai Benhar, Chen Varol, Marc E. Rothenberg, Ariel Munitz
Summary: This study demonstrates the crucial role of IL-13 signaling through IL-13Rα1 in EoE. These findings provide mechanistic insights into current EoE therapies and highlight the potential of targeting the type II IL-4 receptor for future treatment.
Article
Gastroenterology & Hepatology
Tetsuo Shoda, Ting Wen, Julie M. Caldwell, Netali Ben-Baruch Morgenstern, Garrett A. Osswald, Mark Rochman, Lydia E. Mack, Jennifer M. Felton, J. Pablo Abonia, Nicoleta C. Arva, Dan Atkins, Peter A. Bonis, Kelley E. Capocelli, Margaret H. Collins, Evan S. Dellon, Gary W. Falk, Nirmala Gonsalves, Sandeep K. Gupta, Ikuo Hirano, John Leung, Paul A. Menard-Katcher, Vincent A. Mukkada, Philip E. Putnam, Amanda K. Rudman Spergel, Jonathan M. Spergel, Joshua B. Wechsler, Guang-Yu Yang, Seema S. Aceves, Glenn Furuta, Marc E. Rothenberg
Summary: Patients with fibrostenotic EoE express decreased levels of endothelial TSPAN12. IL-13 may promote tissue remodeling in EoE through fibroblast-endothelial cell crosstalk.
Article
Gastroenterology & Hepatology
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Goldi, Franz Oswald, Julien Roux, Mario Noti, Hassan Melhem, Petr Hruz, Jan Hendrik Niess
Summary: This study illustrates the importance of the IL-20 subfamily in maintaining the barrier function of the esophagus in the context of EoE. The dysregulation of IL-20 subfamily signaling disrupts the integrity of the esophageal epithelial barrier and promotes the development of EoE. Targeting the IL-20 subfamily signaling pathway may provide a novel strategy for the treatment of EoE.
Article
Allergy
Leah C. Kottyan, Michael P. Trimarchi, Xiaoming Lu, Julie M. Caldwell, Avery Maddox, Sreeja Parameswaran, Michael Lape, Rahul J. D'Mello, Madeline Bonfield, Adina Ballaban, Vincent Mukkada, Philip E. Putnam, Pablo Abonia, Netali Ben-Baruch Morgenstern, Amy A. Eapen, Ting Wen, Matthew T. Weirauch, Marc E. Rothenberg
Summary: The study identified 6 replicated association and genome-wide significance loci, as well as 7 additional loci with suggestive significance. Thirteen protein-coding EoE candidate risk genes were expressed in a genotype-dependent manner.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Joshua B. Wechsler, Steven J. Ackerman, Mirna Chehade, Katie Amsden, Mary E. Riffle, Ming-Yu Wang, Jian Du, Matt L. Kleinjan, Preeth Alumkal, Elizabeth Gray, Kwang-Youn A. Kim, Barry K. Wershil, Amir F. Kagalwalla
Summary: Novel panels of eosinophil-associated proteins in blood and urine were found to help diagnose eosinophilic esophagitis (EoE) and predict esophageal eosinophilia. These biomarkers, combined with absolute eosinophil count (AEC), were superior to AEC alone in distinguishing EoE from controls and predicting esophageal eosinophil counts.
Article
Gastroenterology & Hepatology
Joshua B. Wechsler, Scott M. Bolton, Elizabeth Gray, Kwang-Youn Kim, Amir F. Kagalwalla
Summary: This study supports the use of endoscopic measurement-guided 3-site biopsies for optimal disease assessment of active EoE in children.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Allergy
Mirna Chehade, Seema S. Aceves
Summary: Eosinophilic esophagitis (EoE) is a chronic disease triggered by antigens, with increasing prevalence in children and adults, leading to complications if left untreated. There have been new clinical trials for EoE therapies, including elimination diets, proton pump inhibitors, swallowed topical corticosteroids, and biologics, with a need for future trials to tailor therapies to individual patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Yoshikazu Kinoshita, Tsuyoshi Sanuki
Summary: This study reviewed the pathogenesis, diagnosis, treatment, and prognosis of non-EoE-EGID, and compared it with EoE cases. The study found that non-EoE-EGID patients had greater systemic involvement and disease severity, but diagnosis was challenging.
Article
Allergy
Lance Y. Hsieh, Austin W. T. Chiang, Loan D. Duong, Chih-Chung Kuo, Stephanie X. Dong, Ranjan Dohil, Richard Kurten, Nathan E. Lewis, Seema S. Aceves
Summary: The study utilized proteomics and primary cells to investigate profibrotic factors in EoE. It was found that fibroblasts from EoE patients secrete a unique ECM proteome that induces collagen and actin expression in normal fibroblasts. Thrombospondin-1 was identified as a previously unrecognized profibrotic molecule in EoE.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Elizabeth Garcia, Zeenat Ladak, Takaaki Landry, Michael Wollin, Amit R. L. Persad, Consolato M. Sergi, Hien Q. Huynh, Rabindranath Persad, Sujata Persad
Summary: This study investigated the role of structural remodeling of cell-cell adhesion in eosinophilic esophagitis (EoE). Through electron microscopy, it was found that intercellular spaces were increased in the EoE group. E-cadherin and ZO-1 levels were decreased, while N-cadherin levels were increased in EoE samples. Additionally, the transcription factor Twist1 was higher in the EoE group and mainly localized to the nucleus. The results suggest that the integrity of esophageal epithelial cells is compromised in EoE patients due to altered expression of cell adhesion molecules and the EMT process.
Article
Gastroenterology & Hepatology
Girish Hiremath, Lili Sun, Margaret H. Collins, Peter A. Bonis, Nicoleta C. Arva, Kelley E. Capocelli, Mirna Chehade, Carla M. Davis, Gary W. Falk, Nirmala Gonsalves, Sandeep K. Gupta, Ikuo Hirano, John Leung, Paneez Khoury, Vincent A. Mukkada, Lisa J. Martin, Jonathan M. Spergel, Joshua B. Wechsler, Guang-Yu Yang, Seema S. Aceves, Glenn T. Furuta, Marc. E. Rothenberg, Tatsuki Koyama, Evan S. Dellon
Summary: Except for the extent of involvement of dilated intercellular spaces in inactive EoE, the involvement of epithelial features and lamina propria in EoE is unevenly distributed across biopsy sites.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Joy W. Chang, Kara Kliewer, Emily Haller, Amanda Lynett, Bethany Doerfler, David A. Katzka, Kathryn A. Peterson, Evan S. Dellon, Nirmala Gonsalves
Summary: Dietary therapy is an effective but poorly utilized treatment strategy for eosinophilic esophagitis. Lack of standardized guidance and access to resources hinder its clinical implementation. This review aims to provide evidence and guidance for providers on initiating and implementing dietary therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Allergy
Susie Min, Tetsuo Shoda, Ting Wen, Marc E. Rothenberg
Summary: This study investigated whether molecular mRNA profiling of a distal esophageal biopsy sample predicts eosinophilia in the proximal esophagus. The results showed a negative correlation between the distal molecular profile score and proximal eosinophil levels. Analysis of histologically negative distal biopsy samples predicted the presence of proximal esophagitis with high sensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Amanda Muir, Gary W. Falk
Summary: Eosinophilic esophagitis is a chronic immune-mediated inflammatory disease of the esophagus that affects both children and adults. Treatments include proton pump inhibitors, topical steroids, elemental diet, and empirical food elimination, with esophageal dilation reserved for patients with symptomatic esophageal narrowing.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Benjamin L. Wright, Alfred D. Doyle, Kelly P. Shim, Rish K. Pai, Suzanne M. Barshow, Jennifer L. Horsley-Silva, Huijun Luo, Matthew A. Rank, Elizabeth A. Jacobsen, David A. Katzka, Hirohito Kita, Evan S. Dellon
Summary: This study evaluated image analysis of EPX immunohistochemistry as an automated method for histologic diagnosis of EoE. EPX/mm(2) correlates strongly with eos/hpf, accurately identifies subjects with EoE, and decreases in treatment responders.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Neurosciences
Kim E. Barrett
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Review
Gastroenterology & Hepatology
Michael Camilleri, Joseph H. Sellin, Kim E. Barrett
Editorial Material
Neurosciences
Kim E. Barrett
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Microbiology
Frederico Alisson-Silva, Janet Z. Liu, Sandra L. Diaz, Lingquan Deng, Melanie G. Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E. Barrett, Ajit Varki
Editorial Material
Immunology
Kim E. Barrett
JOURNAL OF INFECTIOUS DISEASES
(2019)
Editorial Material
Neurosciences
Kim Barrett, Beth Habecker
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Editorial Material
Neurosciences
Ian D. Forsythe, Sally Howells, Kim E. Barrett
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Younjoo Kim, Kim E. Barrett
Meeting Abstract
Biochemistry & Molecular Biology
John Rabalais, Philip Kozan, Tina Lu, Nassim Durali, Matthew D. McGeough, Ron Marchelletta, Jae Beom Lee, Kim Barrett, Mamata Sivagnanam
Meeting Abstract
Biochemistry & Molecular Biology
Alice Drobny, Stella Rita Ibeawuchi, Soumita Das, Lars Bode, Kim Elaine Barrett
Meeting Abstract
Biochemistry & Molecular Biology
Soumita Das, Eileen Lim, Katherine Suarez, Peter B. Ernst, Kim E. Barrett
Correction
Gastroenterology & Hepatology
M. C. Manresa, M. M. Tambuwala, P. Radhakrishnan, J. M. Harnoss, E. Brown, Miguel A. M. A. Cavadas, Ciara E. C. E. Keogh, Alex Cheong, Kim E. K. E. Barrett, E. P. Cummins, M. Schneider, C. T. Taylor
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Rashini Randika Jayaratne, Beom-Jae Lee, Eileen Lim, Kim Barrett, Soumita Das
Review
Gastroenterology & Hepatology
Soumita Das, Rashini Jayaratne, Kim E. Barrett
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2018)