Article
Virology
Andrew T. Abad, Pranav Danthi
Summary: Viruses infect host cells to replicate, but hosts can activate defenses to limit replication. This study provides new insights into how host cells detect the genomes of invading reovirus particles and the factors that determine the magnitude of the immune response triggered during infection.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Tanima SenGupta, Konstantinos Palikaras, Ying Q. Esbensen, Georgios Konstantinidis, Francisco Jose Naranjo Galindo, Kavya Achanta, Henok Kassahun, Ioanna Stavgiannoudaki, Vilhelm A. Bohr, Mansour Akbari, Johannes Gaare, Charalampos Tzoulis, Nektarios Tavernarakis, Hilde Nilsen
Summary: Aging, genomic stress, and mitochondrial dysfunction contribute to neurodegenerative diseases like Parkinson's disease. Base excision repair can generate genomic stress and promote neurodegeneration, while deficiency of NTH-1 may protect against neurotoxicity and rely on mitochondrial transcription for neuroprotection. This highlights the importance of integrating DNA repair mechanisms and transcription regulation in the aging process and susceptibility to neurodegenerative diseases.
Article
Multidisciplinary Sciences
Lu Cui, Zhuoqing Fang, Cristabelle Madona De Souza, Tristan Lerbs, Yuan Guan, Irene Li, Vivek Charu, Shih-Yu Chen, Irving Weissman, Gerlinde Wernig
Summary: COVID-19 is a global pandemic with millions of people developing COVID lung fibrosis. Studies have shown that patients with long COVID have a unique immune signature with upregulated proinflammatory and innate immune effector genes. By modeling the transition to lung fibrosis after COVID in mice, researchers found chronic immune activation similar to long COVID in humans. By treating a humanized COVID lung fibrosis model, they were able to ameliorate fibrosis and restore innate immune equilibrium, suggesting potential implications for clinical management.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Najmeh Soltanmohammadi, Siyao Wang, Bjoern Schumacher
Summary: This study reveals that stress signaling from intestinal cells regulates elimination of germ cells carrying damaged genomes, which in turn impacts inheritance. Failure of intestinal signaling results in stress-induced aneuploidy.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Jinlong Wan, Lei Yuan, Huiru Jing, Qian Zheng, Hui Xiao
Summary: Clearance of apoptotic cells is crucial for multicellular organisms and tissue homeostasis. In C. elegans, defects in apoptotic cell clearance can protect the worms from bacterial infection by activating the innate immune response.
Article
Cell Biology
Jeong-Hoon Hahm, Farida S. Nirmala, Pyeong Geun Choi, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, Jiyun Ahn
Summary: Dietary restriction (DR) is an effective intervention for prolonging longevity in many organisms, but the molecular mechanisms by which DR influences aging and immunity are not fully understood. Through studying Caenorhabditis elegans, researchers discovered that the F-box gene fbxc-58 mediates the beneficial effects of DR on extending the health span of the worm and preventing mitochondrial deterioration during aging.
Article
Biology
Dina Aggad, Nicolas Brouilly, Shizue Omi, Clara Luise Essmann, Benoit Dehapiot, Cathy Savage-Dunn, Fabrice Richard, Chantal Cazevieille, Kristin A. Politi, David H. Hall, Remy Pujol, Nathalie Pujol, Piali Sengupta
Summary: In mutants lacking furrows, the normal connection between the epidermis and the cuticle is lost, and stacked structures are formed in the lateral epidermis. These structures connect the lateral epidermis to the cuticle and play a role in the stress response. Additionally, furrow mutants exhibit significant changes in the biomechanical properties of their skin.
Review
Immunology
Emily Horner, Janet M. Lord, Jon Hazeldine
Summary: Major traumatic injury leads to systemic immunosuppression, and DAMPs are detected in the circulation following injury and are known to initiate the inflammatory response. Recent research suggests that DAMPs may also play a role in immune suppression after trauma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee
Summary: Mitochondrial Krebs cycle plays a crucial role in immunity, and the genetic inhibition of mitochondrial aconitase can enhance immunity against pathogenic bacteria.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Huanliang Liu, Yu Wu, Zhenyu Wang
Summary: This study found that the heme homeostasis signal participates in inducing a protective response when controlling nanopolystyrene toxic effects in the parental generation. However, its role in the regulation of transgenerational toxicity of nanopolystyrene toxicity is unclear. Using Caenorhabditis elegans as a model organism, it was discovered that nanopolystyrene particles downregulated the glb-18 gene expression in both the parental generation and the offspring. Lower levels of GLB-18 led to increased susceptibility to transgenerational toxicity of nanopolystyrene. Importantly, germline GLB-18 activated the downstream intestinal HRG-4/HRG-1/ATFS-1/HSP-6 pathway to control the transgenerational toxicity of nanopolystyrene. These findings suggest a possible association between changes in heme homeostasis signal and transgenerational nanoplastic toxicity within organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Tianhao Duan, Yanchun Feng, Yang Du, Changsheng Xing, Junjun Chu, Jiayu Ou, Xin Liu, Motao Zhu, Chen Qian, Bingnan Yin, Helen Y. Wang, Jun Cui, Rong-Fu Wang
Summary: This study reveals the involvement of ubiquitin-specific protease 3 (USP3) in establishing tolerance innate immune memory through non-transcriptional feedback, and its critical role in NF-kappa B signaling pathway.
Review
Biochemistry & Molecular Biology
Thomas J. Hayman, Peter M. Glazer
Summary: Research on disease treatment has focused on DNA repair pathways, with potential for enhanced efficacy with novel immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Eliana M. Barros, Stuart A. McIntosh, Kienan I. Savage
Summary: Genomic instability is a hallmark of tumourigenesis, and defects in the DNA damage response (DDR) play a crucial role in shaping therapeutic response. The cGAS/STING signalling pathway has been identified as a key mediator of inflammation in response to DNA damage. Multiple DNA repair defects and DNA damage induced by conventional chemotherapy/radiation can also activate the innate immune response through cGAS/STING activation. Combining DNA damaging agents with immunotherapies has potential therapeutic opportunities.
Article
Multidisciplinary Sciences
Yu Cao, Florian Kuemmel, Elke Logemann, Jan M. Gebauer, Aaron W. Lawson, Dongli Yu, Matthias Uthoff, Beat Keller, Jan Jirschitzka, Ulrich Baumann, Kenichi Tsuda, Jijie Chai, Paul Schulze-Lefert
Summary: In plants, the coevolution between host and pathogen is reflected in adaptive genetic changes in host immune receptors and pathogen effectors. This study focuses on the RNase-like effector family RALPH in grass powdery mildew fungi and reveals variations in the structures and activities of the RALPH effectors. The findings provide insights into the escape of powdery mildew fungi from host recognition and the acquisition of diverse virulence functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Environmental Sciences
Xiangyin Zeng, Runze Liu, Yutao Li, Jianhong Li, Qian Zhao, Xiang Li, Jun Bao
Summary: This study found that excessive NH3 inhalation had effects on the transcriptional profiles and liver function in fattening pigs, leading to oxidative stress and immune dysfunction, which resulted in liver damage. The study not only provided a new perspective for assessing the toxicity of NH3, but also enriched the toxicological mechanism of NH3.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Rong Fu, Xiaowan Jiang, Gang Li, Yi Zhu, Huimin Zhang
Summary: The cell-cell and cell-ECM junctions in epithelial tissues play crucial roles in providing architectural stability, mechanical resistance, and permeability control, as well as regulating innate immune defense, stress resistance, and intracellular proteostasis of epithelial cells. Their multitasking nature extends beyond anchorage-dependent or cell shape change-related processes.
Article
Materials Science, Multidisciplinary
Jinghao Rong, Huimin Zhang, Pengjun Zhao, Qing Qin, Donglin He, Juntao Xie, Yuning Ding, Hui Jiang, Bin Wu, Aimin Chang
Summary: Zn/Fe co-doped Co-Mn-Ni-O negative temperature coefficient ceramics were prepared by solid-phase method. The ceramics showed stability in phase structure and had dense and homogeneous grains. The specimens with Zn/Fe co-doping had smaller grain size and the resistivity showed a linear relationship with the inverse of temperature.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Psychiatry
Shanshan He, Fan Yang, Huimin Zhang, Shumiao Zhang
Summary: Becoming a mother is a significant challenge for most women in urban China due to a lack of childcare facilities and high social expectations. This study aims to examine the affective well-being of Chinese urban postpartum women and its association with spousal support and maternal role adaptation.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Ye Tian, Shuo Li, Kuan Dong, Xiaolu Su, Siyu Fu, Xuening Lv, Meibo Duan, Ting Yang, Yu Han, Guangda Hu, Jialu Liu, Yanping Sun, Hao Yue, Yongjun Sun, Huimin Zhang, Zhidian Du, Zhenyu Miao, Minghui Tong, Yajing Liu, Mingze Qin, Ping Gong, Yunlei Hou, Zibin Gao, Yanfang Zhao
Summary: This study reported the discovery of a series of benzamide derivatives containing urea moiety as soluble epoxide hydrolase (sEH) inhibitors, and the identification of compound A34 as a potent sEH inhibitor with good physicochemical properties through intensive structural modifications. Compound A34 exhibited outstanding inhibitory activity against human sEH and showed moderate systemic drug exposure and oral bioavailability in vivo metabolism studies. In a carrageenan-induced inflammatory pain rat model, compound A34 exhibited a better therapeutic effect compared to other comparison drugs. Metabolism studies in vivo and inflammatory pain evaluation suggest that A34 may serve as a promising lead compound for the development of highly potent sEH inhibitors.
BIOORGANIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Juntao Xie, Hongtao Li, Xu Sang, Huimin Zhang, Aimin Chang
Summary: The ceramic-polymer composite flexible films composed of BVT fillers and PVDF matrix were prepared using a solid-state reaction method. SEM tests showed that as the powder content increased, the film density and the interface effect between the polymer and powder decreased. The measurement results of the dielectric constant and dielectric loss of the film indicated that reducing the content of BVT powder could reduce the dielectric loss of the film under certain conditions.
Article
Materials Science, Ceramics
Xianghui Chen, Yan Xue, Bo Zhang, Pengjun Zhao, Yuyu Liu, Xuelian Bai, Bing Wu, Ye Pan, Huimin Zhang, Aimin Chang, Yongxin Xie
Summary: A series of new negative temperature coefficient (NTC) thermal materials based on (Ba0.85Ca0.15)(1-x)Ce-x/2(Zr0.1Ti0.9)O-3 ceramics were synthesized and their crystal structure, morphology, composition and performance characteristics were investigated. It was found that the average grain size of doped ceramic samples experienced a decrease-then-increase trend, and the doping of Ce reduced the sintering temperature. The thermal constant and activation energy initially increased and then decreased with increasing doping amount, and the concentration of oxygen vacancies was influenced by the transition of Ce ions. The (Ba0.85Ca0.15)(1-x)Ce-x/2(Zr0.1Ti0.9)O-3 ceramics exhibited excellent negative temperature characteristics at high temperatures and showed improved temperature resistance linearity after aging.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Yan Xue, Wenye Deng, Yuyu Liu, Xuelian Bai, Xianghui Chen, Pengjun Zhao, Ye Pan, Huimin Zhang, Aimin Chang, Yongxin Xie
Summary: A series of novel negative temperature coefficient (NTC) thermistor materials based on La1-xCexAlO3 (0 <= x <= 0.2) ceramics were synthesized via the solid-state route. Ce doping was found to increase the average grain size and density of the samples, while reducing the resistivity and B200/1400 value of the LaAlO3 materials. X-ray photoelectron spectroscopy results revealed that Ce doping decreased the resistivity by increasing the concentration of Ce3+ and oxygen vacancies. The La1-xCexAlO3 (0 <= x <= 0.2) series materials exhibited good linear NTC characteristics and were identified as promising materials for NTC applications.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Yifeng Zhao, Wenye Deng, Xianghui Chen, Huimin Zhang, Aimin Chang, Yongxin Xie
Summary: In this study, alkali metal doping was achieved using the sol-gel method to obtain thermally sensitive ceramic materials. XRD results showed that the doping did not introduce impurity phases. SEM analysis demonstrated that the doping of Li enhanced the grain size, while Na and K doping decreased the grain size. The resistivity of the ceramic samples exhibited an increasing trend with Li doping. The findings confirm the potential of the Mn1.2Ni0.3Co1.5-x(Li/Na/K)(x)O-4 family as low-temperature NTC heat-sensitive materials.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Multidisciplinary Sciences
Wenwei Liu, Huimin Zhang, Haichen Zhang, Tongzhou Lyu, Suwei Yuan
Summary: This study assessed the appropriateness of hospital utilization by children in a secondary hospital in Shanghai, finding that 38.5% of admissions and 9.5% of hospital days were inappropriate. Factors associated with inappropriateness included non-Shanghai residency, admission through the emergency sector, and treatment in a surgical ward.
Correction
Chemistry, Multidisciplinary
Feiran Wang, Jian Song, Yingying Yan, Qian Zhou, Xiaojing Li, Ping Wang, Zongtong Yang, Qiuhong Zhang, Huimin Zhang
Article
Nanoscience & Nanotechnology
Yue Qin, Huimin Zhang, Qilin Yuan, Hanzhuang Zhang, Jiajia Ning, Wenyu Ji
Summary: Cd-free AgInZnS (AIZS) nanocrystals produced via cation exchange reaction can be used as green emitters in light-emitting diodes with high current efficiency and external quantum efficiency. The composition of AIZS NCs produced with different ligands can affect the charge injection balance in the device, leading to different performances of AIZS NC-based light-emitting diodes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biophysics
Qian Lai, Juan Song, Jie Zha, Huijian Zheng, Manman Deng, Yilong Liu, Wei Lin, Zhi Zhu, Huimin Zhang, Bing Xu, Chaoyong Yang
Summary: The article introduces a novel non-invasive method for monitoring remission status and predicting prognosis in AML patients using the LSC-Chip. By capturing and releasing leukemic stem cells (LSCs), accurate counting of LSCs, subtype classification, and single-cell RNA sequencing analysis can be performed.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Geriatrics & Gerontology
Pingkang Xu, Qimin Chen, Xiaoman Chen, Hao Qi, Yuyan Yang, Weiqi Li, Xin Yang, Amelia Gunawan, Shuoyu Chen, Huimin Zhang, Han-Ming Shen, Dejian Huang, Brian Kennedy, Li Xu, Ziyun Wu
Summary: This study demonstrates that morusin and mulberrin can extend the lifespan of yeast and C. elegans by targeting SCH9 and akt-1 or akt-2 genes, respectively. Additionally, they exhibit other benefits in worms and slow cell senescence in HeLa cells.
Article
Multidisciplinary Sciences
Shichao Lin, Kun Yin, Yingkun Zhang, Fanghe Lin, Xiaoyong Chen, Xi Zeng, Xiaoxu Guo, Huimin Zhang, Jia Song, Chaoyong Yang
Summary: In this study, a method called Well-TEMP-seq was developed, which is a high-throughput, cost-effective, accurate, and efficient approach for profiling the temporal dynamics of single-cell gene expression. By combining metabolic RNA labeling with single-cell RNA sequencing, Well-TEMP-seq can distinguish newly transcribed RNAs from pre-existing RNAs in thousands of single cells. The application of this method to colorectal cancer cells exposed to the DNA demethylating drug 5-AZA-CdR revealed its unbiased capturing of RNA dynamics and superior performance compared to splicing-based RNA velocity method.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Qin Wang, Rong Fu, Gang Li, Shaojie Xiong, Yi Zhu, Huimin Zhang
Summary: Hedgehog signaling plays important roles in epithelial barrier tissues' development and homeostasis. The study reveals the direct regulation of innate immunity in epithelial cells by Hedgehog signaling. Loss of Patched family receptor induces up-regulation of antimicrobial peptides in epidermis through a STAT-dependent pathway. The findings demonstrate the immune-surveillance function of Hedgehog receptors and the insult-sensing and response strategy of epithelial tissues.
