Keratin 6a reorganization for ubiquitin–proteasomal processing is a direct antimicrobial response

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo

(2016) R P Hobbs et al.   ONCOGENE

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Membrane-Active Epithelial Keratin 6A Fragments (KAMPs) Are Unique Human Antimicrobial Peptides with a Non-αβ Structure

(2016) Judy T. Y. Lee et al.   Frontiers in Microbiology

Epithelial Intermediate Filaments: Guardians against Microbial Infection?

(2016) Florian Geisler et al.   Cells

EGFR kinase activity is required for TLR4 signaling and the septic shock response

(2015) S. Chattopadhyay et al.   EMBO REPORTS

The Importance of the Pseudomonas aeruginosa Type III Secretion System in Epithelium Traversal Depends upon Conditions of Host Susceptibility

(2015) Aaron B. Sullivan et al.   INFECTION AND IMMUNITY

Keratin 1 Plays a Critical Role in Golgi Localization of Core 2N-Acetylglucosaminyltransferase M via Interaction with Its Cytoplasmic Tail

(2015) Armen Petrosyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes

(2015) Ryan P Hobbs et al.   NATURE GENETICS

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal

(2015) Sarmishtha De et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection

(2015) Abraam M. Yakoub et al.   Scientific Reports

The immunoproteasome and viral infection: a complex regulator of inflammation

(2015) Mary K. McCarthy et al.   Frontiers in Microbiology

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

(2014) Guangshun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Signal Integration and Gene Induction by a Functionally Distinct STAT3 Phosphoform

(2014) M. S. Waitkus et al.   MOLECULAR AND CELLULAR BIOLOGY

Post-translational modifications of intermediate filament proteins: mechanisms and functions

(2014) Natasha T. Snider et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

(2014) Bingrong Tang et al.   PLoS One

CD14 Mediates Toll-like Receptor 4 (TLR4) Endocytosis and Spleen Tyrosine Kinase (Syk) and Interferon Regulatory Transcription Factor 3 (IRF3) Activation in Epithelial Cells and Impairs Neutrophil Infiltration andPseudomonas aeruginosaKillingin Vivo

(2013) Sanhita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratin 9 Is Required for the Structural Integrity and Terminal Differentiation of the Palmoplantar Epidermis

(2013) Dun Jack Fu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Surfactant Protein D Contributes to Ocular Defense against Pseudomonas aeruginosa in a Murine Model of Dry Eye Disease

(2013) Susan R. Heimer et al.   PLoS One

A Reconstituted Telomerase-Immortalized Human Corneal EpitheliumIn Vivo: A Pilot Study

(2012) Danielle M. Robertson et al.   CURRENT EYE RESEARCH

The expanding significance of keratin intermediate filaments in normal and diseased epithelia

(2012) Xiaoou Pan et al.   CURRENT OPINION IN CELL BIOLOGY

A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair

(2012) Jeremy D. Rotty et al.   JOURNAL OF CELL BIOLOGY

Cytokeratins mediate epithelial innate defense through their antimicrobial properties

(2012) Connie Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Cornea Proteome: Identification and Quantitation of the Proteins of the Three Main Layers Including Epithelium, Stroma, and Endothelium

(2012) Thomas F. Dyrlund et al.   JOURNAL OF PROTEOME RESEARCH

Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins

(2011) Marisa Ponpuak et al.   Autophagy

Interferon-γ-induced MD-2 Protein Expression and Lipopolysaccharide (LPS) Responsiveness in Corneal Epithelial Cells Is Mediated by Janus Tyrosine Kinase-2 Activation and Direct Binding of STAT1 Protein to the MD-2 Promoter

(2011) Sanhita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

(2011) Reinhard Windoffer et al.   JOURNAL OF CELL BIOLOGY

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Role of Defensins in Corneal Epithelial Barrier Function againstPseudomonas aeruginosaTraversal

(2010) Danielle K. Augustin et al.   INFECTION AND IMMUNITY

The keratin-filament cycle of assembly and disassembly

(2010) A. Kolsch et al.   JOURNAL OF CELL SCIENCE

E1^E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium

(2010) P. B. McIntosh et al.   JOURNAL OF CELL SCIENCE

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

(2010) Nam-On Ku et al.   NATURE CELL BIOLOGY

Flagellin-Induced Corneal Antimicrobial Peptide Production and Wound Repair Involve a Novel NF-κB–Independent and EGFR-Dependent Pathway

(2010) Nan Gao et al.   PLoS One

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

(2009) V. Leung-Pineda et al.   CANCER RESEARCH

SnapShot: F Box Proteins II

(2009) Jeffrey R. Skaar et al.   CELL

Clearance of Pseudomonas aeruginosa from a Healthy Ocular Surface Involves Surfactant Protein D and Is Compromised by Bacterial Elastase in a Murine Null-Infection Model

(2009) J. J. Mun et al.   INFECTION AND IMMUNITY

Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

(2009) Arunan S. Vamadevan et al.   Innate Immunity

Intermediate filaments: primary determinants of cell architecture and plasticity

(2009) Harald Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

Characterization of ΔNp63 isoforms in normal cornea and telomerase-immortalized human corneal epithelial cells

(2008) Danielle M. Robertson et al.   EXPERIMENTAL EYE RESEARCH

The human keratins: biology and pathology

(2008) Roland Moll et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness

(2008) Jing Zhang et al.   IMMUNOLOGY AND CELL BIOLOGY

Ubiquitin-Proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells

(2008) Ariel Jaitovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbial Patterns Signaling via Toll-Like Receptors 2 and 5 Contribute to Epithelial Repair, Growth and Survival

(2008) Renat Shaykhiev et al.   PLoS One