TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs

A novel ocular function for decorin in the aqueous humor outflow

(2021) Magdalena Schneider et al.   MATRIX BIOLOGY

Transforming growth factor–β in tissue fibrosis

(2020) Nikolaos G. Frangogiannis   JOURNAL OF EXPERIMENTAL MEDICINE

Tendon‐derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin/transforming growth factor‐β crosstalk‐mediated mechanism

(2020) Dan Wang et al.   FASEB JOURNAL

TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibrosis

(2020) Rodrigo Carlos de Oliveira et al.   EXPERIMENTAL EYE RESEARCH

Quantitative proteomic comparison of myofibroblasts derived from bone marrow and cornea

(2020) Paramananda Saikia et al.   Scientific Reports

Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis

(2020) Pernille Juhl et al.   Scientific Reports

Corneal myofibroblasts and fibrosis

(2020) Steven E. Wilson   EXPERIMENTAL EYE RESEARCH

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

(2019) Kah Yong Goh et al.   Redox Biology

Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29

(2019) N.E. Calabro et al.   MATRIX BIOLOGY

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

(2019) Daniela L. Rebolledo et al.   MATRIX BIOLOGY

Identification of atrial fibrillation‐associated lncRNAs in atria from patients with rheumatic mitral valve disease

(2019) Jine Wu et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Distinct Binding Interactions of α5β1-Integrin and Proteoglycans with Fibronectin

(2019) Thomas M. Kennelly et al.   BIOPHYSICAL JOURNAL

ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart

(2019) Yufeng Yao et al.   CARDIOVASCULAR RESEARCH

The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

(2019) Alan R.F. Godwin et al.   MATRIX BIOLOGY

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers

(2019) Roger Valle-Tenney et al.   MATRIX BIOLOGY

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis

(2019) Abdullah M. AlMegbel et al.   DIFFERENTIATION

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury

(2018) Luciana Lassance et al.   EXPERIMENTAL EYE RESEARCH

Knockout of tissue transglutaminase ameliorates TGFβ2-induced ocular hypertension: A novel therapeutic target for glaucoma?

(2018) Urmimala Raychaudhuri et al.   EXPERIMENTAL EYE RESEARCH

MicroRNA Control of TGF-β Signaling

(2018) Hiroshi Suzuki   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease

(2018) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

PDGF in organ fibrosis

(2018) Barbara Mara Klinkhammer et al.   MOLECULAR ASPECTS OF MEDICINE

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

(2018) Harinarayanan Janakiraman et al.   MOLECULAR CANCER RESEARCH

Novel Differences in Gene Expression and Functional Capabilities of Myofibroblast Populations in Idiopathic Pulmonary Fibrosis

(2018) Sinead M Walsh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TGF-β receptors: In and beyond TGF-β signaling

(2018) Alexandra Vander Ark et al.   CELLULAR SIGNALLING

Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological Conditions

(2018) Takeshi Tsuda   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits

(2017) Gustavo K. Marino et al.   EXPERIMENTAL EYE RESEARCH

Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt

(2017) Alícia Giménez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary Fibrosis

(2017) Hara Kang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regeneration of Defective Epithelial Basement Membrane and Restoration of Corneal Transparency After Photorefractive Keratectomy

(2017) Gustavo K. Marino et al.   JOURNAL OF REFRACTIVE SURGERY

Injury and defective regeneration of the epithelial basement membrane in corneal fibrosis: A paradigm for fibrosis in other organs?

(2017) Steven E. Wilson et al.   MATRIX BIOLOGY

Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin

(2017) Patricia Paracuellos et al.   MATRIX BIOLOGY

Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?

(2017) Katarzyna Pietraszek-Gremplewicz et al.   MATRIX BIOLOGY

The nature and biology of basement membranes

(2017) Ambra Pozzi et al.   MATRIX BIOLOGY

TGF-β3 Inhibits Antibody Production by Human B Cells

(2017) Yumi Tsuchida et al.   PLoS One

Lumican Peptides: Rational Design Targeting ALK5/TGFBRI

(2017) Tarsis Ferreira Gesteira et al.   Scientific Reports

Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis

(2016) Aaron R. Froese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Temporal and Spatial Expression of Transforming Growth Factor-β after Airway Remodeling to Tobacco Smoke in Rats

(2016) Laura L. Hoang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma

(2016) Alex Zhavoronkov et al.   CELL CYCLE

Small leucine-rich repeat proteoglycans in corneal inflammation and wound healing

(2016) Jihane Frikeche et al.   EXPERIMENTAL EYE RESEARCH

Molecular insights on the effect of TGF-β1/-β3 in human corneal fibroblasts

(2016) Xiaoqing Guo et al.   EXPERIMENTAL EYE RESEARCH

Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding

(2016) Senem Aykul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

(2016) Michael K. Lichtman et al.   WOUND REPAIR AND REGENERATION

Agonists and Antagonists of TGF-β Family Ligands

(2016) Chenbei Chang   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Restoration of Corneal Transparency by Mesenchymal Stem Cells

(2016) Sharad K. Mittal et al.   Stem Cell Reports

The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway

(2016) Xiang Xue et al.   PLoS One

Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

(2015) Satoshi Kubota et al.   CLINICAL SCIENCE

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development

(2015) Jamie Lane et al.   DEVELOPMENTAL BIOLOGY

Tumors of the ocular surface: A review

(2015) SantoshG Honavar et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

miR-30c and miR-193 are a part of the TGF-β-dependent regulatory network controlling extracellular matrix genes in liver fibrosis

(2015) Sanchari Roy et al.   Journal of Digestive Diseases

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AFAP1 Is a Novel Downstream Mediator of TGF-β1 for CCN2 Induction in Osteoblasts

(2015) Youngjin Cho et al.   PLoS One

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis

(2014) Yoshinori Aono et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of microRNA machinery in kidney fibrosis

(2014) Bo Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Reversal of fibrosis by TGF-β3 in a 3D in vitro model

(2014) D. Karamichos et al.   EXPERIMENTAL EYE RESEARCH

TGFβ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo

(2014) Vivek Singh et al.   EXPERIMENTAL EYE RESEARCH

Deregulated expression of connective tissue growth factor (CTGF/CCN2)is linked to poor outcome in human cancer

(2014) Julia E. Wells et al.   INTERNATIONAL JOURNAL OF CANCER

The Role of TGF-β2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma

(2014) Robert J. Wordinger et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

PDGF-D Expression Is Down-Regulated by TGFβ in Fibroblasts

(2014) Saima Charni Chaabane et al.   PLoS One

Circular RNAs: diversity of form and function

(2014) Erika Lasda et al.   RNA

TGF-β1 Up-Regulates the Expression of PDGF-β Receptor mRNA and Induces a Delayed PI3K-, AKT-, and p70S6K-Dependent Proliferative Response in Activated Hepatic Stellate Cells

(2013) Ruchi Shah et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Notch Signal Regulates Corneal Endothelial-to-Mesenchymal Transition

(2013) Cheng Li et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Circular RNAs: splicing’s enigma variations

(2013) Matthias W Hentze et al.   EMBO JOURNAL

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β3 (TGF-β3) Knock-in Ameliorates Inflammation Due to TGF-β1 Deficiency While Promoting Glucose Tolerance

(2013) Bradford E. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Decorin

(2012) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

MicroRNAs and fibrosis

(2012) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Tsukushi controls the hair cycle by regulating TGF-β1 signaling

(2012) Daisuke Niimori et al.   DEVELOPMENTAL BIOLOGY

Hepatocyte Growth Factor Reduces Cardiac Fibrosis by Inhibiting Endothelial-Mesenchymal Transition

(2012) Keita Okayama et al.   HYPERTENSION

Matrix control of transforming growth factor-  function

(2012) M. Horiguchi et al.   JOURNAL OF BIOCHEMISTRY

Decorin–TGFβ Axis in Hepatic Fibrosis and Cirrhosis

(2012) Kornélia Baghy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

MicroRNAs, transforming growth factor beta-1, and tissue fibrosis

(2012) Timothy Bowen et al.   JOURNAL OF PATHOLOGY

Thrombospondins in physiology and disease: New tricks for old dogs

(2012) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo

(2012) Mark Le et al.   PLoS One

Induction of epithelial–mesenchymal transition by transforming growth factor β

(2012) Aristidis Moustakas et al.   SEMINARS IN CANCER BIOLOGY

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction

(2011) Fatih Arslan et al.   CIRCULATION RESEARCH

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Localization of thrombospondin-1 and myofibroblasts during corneal wound repair

(2011) Mariko Matsuba et al.   EXPERIMENTAL EYE RESEARCH

Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice

(2011) V. Singh et al.   EXPERIMENTAL EYE RESEARCH

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

(2011) Craig A. Harrison et al.   GROWTH FACTORS

Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity

(2011) Dragana Nikitovic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-β and Potentiates Fibrosis

(2011) Paraskevi Briassouli et al.   JOURNAL OF IMMUNOLOGY

Recipient-derived EDA fibronectin promotes cardiac allograft fibrosis

(2011) Adam J Booth et al.   JOURNAL OF PATHOLOGY

Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model

(2011) D. Karamichos et al.   Journal of Tissue Engineering and Regenerative Medicine

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Post-Transcriptional Regulation of Transforming Growth Factor Beta-1 by MicroRNA-744

(2011) John Martin et al.   PLoS One

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK

(2010) Maren Bakkebø et al.   BMC IMMUNOLOGY

rAAV2-TGF-β3 Decreases Collagen Synthesis and Deposition in the Liver of Experimental Hepatic Fibrosis Rat

(2010) Yi Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts

(2010) Rajiv R. Mohan et al.   EXPERIMENTAL EYE RESEARCH

The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head

(2010) Rudolf Fuchshofer   EXPERIMENTAL EYE RESEARCH

The extra domain A of fibronectin is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice

(2010) Martin Kohan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Binding characteristics of the osteoarthritis-associated protein asporin

(2010) Ikuyo Kou et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice

(2010) Kornélia Baghy et al.   LABORATORY INVESTIGATION

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Update on the pathophysiology of liver fibrosis

(2010) Massimo Pinzani et al.   Expert Review of Gastroenterology & Hepatology

Fetal Testis Dysgenesis and Compromised Leydig Cell Function in Tgfbr3 (Betaglycan) Knockout Mice1

(2009) Mai A. Sarraj et al.   BIOLOGY OF REPRODUCTION

Long-Term Evaluation of Complications and Results of Photorefractive Keratectomy in Myopia: An 8-Year Follow-Up

(2009) Ahmad Shojaei et al.   CORNEA

Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

(2009) Mark WJ Ferguson et al.   LANCET

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mechanisms of Fibrogenesis

(2008) Tatiana Kisseleva et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway

(2008) Dmitri V. Pechkovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy

(2008) Enrique Brandan et al.   MATRIX BIOLOGY

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3

(2007) Kjetil Ask et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY