MicroRNA Control of TGF-β Signaling

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer

(2018) Andrija Matak et al.   HEPATOLOGY

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

(2018) Harinarayanan Janakiraman et al.   MOLECULAR CANCER RESEARCH

Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

(2018) Hiroshi I. Suzuki et al.   NATURE GENETICS

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary Fibrosis

(2017) Hara Kang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases

(2017) Evangelia Pardali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of TGF-β-mediated endothelial-mesenchymal transition by microRNA-27

(2017) Hiroshi I. Suzuki et al.   JOURNAL OF BIOCHEMISTRY

Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis

(2017) Jung Soo Lee et al.   Biomed Research International

miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis

(2016) Shao-Lai Zhou et al.   HEPATOLOGY

FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling

(2016) Ana C. P. Correia et al.   JOURNAL OF CELL SCIENCE

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

(2016) Merve Mutlu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis

(2016) Wei Chen et al.   TUMOR BIOLOGY

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

(2016) Jingyi Yu et al.   Nature Communications

A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome

(2015) Bastian Fromm et al.   Annual Review of Genetics

A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B

(2015) Hiroshi I. Suzuki et al.   CANCER SCIENCE

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β

(2015) Akihiro Katsura et al.   GENES TO CELLS

Harnessing RNA Interference for Therapy

(2015) Judy Lieberman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer

(2015) Lingling Guo et al.   TUMOR BIOLOGY

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

(2015) Brock Humphries et al.   Oncotarget

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

(2015) Jia Ma et al.   Oncotarget

Critical role of miR-10b in transforming growth factor-β1-induced epithelial–mesenchymal transition in breast cancer

(2014) Xu Han et al.   CANCER GENE THERAPY

Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion

(2014) C. P. Bracken et al.   EMBO JOURNAL

Down-regulation of MicroRNA-494 via Loss of SMAD4 Increases FOXM1 and β-Catenin Signaling in Pancreatic Ductal Adenocarcinoma Cells

(2014) Lei Li et al.   GASTROENTEROLOGY

MicroRNA-155 and MicroRNA-21 Promote the Expansion of Functional Myeloid-Derived Suppressor Cells

(2014) L. Li et al.   JOURNAL OF IMMUNOLOGY

Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

(2014) Andrew D. Bosson et al.   MOLECULAR CELL

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA regulons in tumor microenvironment

(2014) H I Suzuki et al.   ONCOGENE

TGF- -inducible microRNA-183 silences tumor-associated natural killer cells

(2014) S. S. Donatelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells

(2014) Kai Zhu et al.   Scientific Reports

Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP

(2014) Yoosik Kim et al.   Cell Reports

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII

(2013) Ting-Hui Chu et al.   CANCER LETTERS

Signaling between Transforming Growth Factor β (TGF-β) and Transcription Factor SNAI2 Represses Expression of MicroRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis

(2013) Xiangming Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-584 and the Protein Phosphatase and Actin Regulator 1 (PHACTR1), a New Signaling Route through Which Transforming Growth Factor-β Mediates the Migration and Actin Dynamics of Breast Cancer Cells

(2013) Nadège Fils-Aimé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes

(2013) H I Suzuki et al.   LEUKEMIA

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer

(2013) S Mishra et al.   ONCOGENE

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway

(2013) Junfeng Zhang et al.   PLoS One

Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation

(2013) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation

(2013) Qiong Li et al.   Scientific Reports

MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT

(2013) Swayam Prakash Srivastava et al.   Biomed Research International

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

(2012) Asish K. Ghosh et al.   CELLULAR SIGNALLING

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

(2012) Libing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β upregulates miR-181a expression to promote breast cancer metastasis

(2012) Molly A. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs, transforming growth factor beta-1, and tissue fibrosis

(2012) Timothy Bowen et al.   JOURNAL OF PATHOLOGY

MicroRNA-590-5p regulates proliferation and invasion in human hepatocellular carcinoma cells by targeting TGF-β RII

(2012) Xiaofeng Jiang et al.   MOLECULES AND CELLS

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

(2012) Gavriel Mullokandov et al.   NATURE METHODS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis

(2012) Hiroshi I. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

Crosstalk between TGF-β signaling and the microRNA machinery

(2012) Henriett Butz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF R2) in colon cancer cells

(2011) Y. Yu et al.   CARCINOGENESIS

MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production

(2011) Anne Karine Lagendijk et al.   CIRCULATION RESEARCH

miRNAs and regulation of cell signaling

(2011) Atsuhiko Ichimura et al.   FEBS Journal

Suppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs

(2011) Afzal M. Dogar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   MOLECULAR BIOLOGY OF THE CELL

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Shielding the messenger (RNA): microRNA-based anticancer therapies

(2011) Elena Sotillo et al.   PHARMACOLOGY & THERAPEUTICS

Tumor-promoting functions of transforming growth factor-β in progression of cancer

(2011) Kohei Miyazono et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

(2010) Kusum V. Pandit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor

(2010) Hailin Wang et al.   BRAIN RESEARCH

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

Analysis of microRNA knockouts in mice

(2010) C. Y. Park et al.   HUMAN MOLECULAR GENETICS

Emerging complexity of microRNA generation cascades

(2010) H. I. Suzuki et al.   JOURNAL OF BIOCHEMISTRY

Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway

(2010) Hiroshi I. Suzuki et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

(2010) Pieter Mestdagh et al.   MOLECULAR CELL

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGFβ effectors, Drosha and microRNAs with opposite oncogenic potentials

(2010) Esmerina Tili et al.   NUCLEIC ACIDS RESEARCH

Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM

(2010) Y Wang et al.   ONCOGENE

Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas

(2010) J Braun et al.   ONCOGENE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

(2009) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

(2009) Mitsuo Kato et al.   NATURE CELL BIOLOGY

TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

(2009) B Wang et al.   ONCOGENE

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

(2008) M. Inomata et al.   BLOOD

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

(2008) Fabio Petrocca et al.   CANCER CELL

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells

(2008) Alexander Marson et al.   CELL

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Upregulation of miR-23a∼27a∼24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells

(2008) Shenglin Huang et al.   INTERNATIONAL JOURNAL OF CANCER

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY