Article
Biochemistry & Molecular Biology
Yi-Hui Wu, Yu-Fang Huang, Tzu-Hao Chang, Chien-Chin Chen, Pei-Ying Wu, Soon-Cen Huang, Cheng-Yang Chou
Summary: The study indicates that high COL11A1-expressing EOC cells promote CAF activation and tumor development, while treatment with TGF-beta3 antibody inhibits COL11A1-induced CAF activation. Patients with high levels of TGF-beta3 and COL11A1 show poor survival outcomes.
Article
Pharmacology & Pharmacy
Na Jiang, Jing Zhang, Jian Ping, Lieming Xu
Summary: This article investigates the role of salvianolic acid B (Sal B) in autophagy of hepatic stellate cells (HSCs) in liver fibrosis. The study shows that TGF-beta 1 induces autophagosome formation and flux in HSCs, while Sal B inhibits autophagy and activation of HSCs by suppressing autophagosome formation and flux. Furthermore, Sal B inhibits TGF-beta 1-induced autophagy and activation of HSCs by downregulating the MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Leonie Berten-Schunk, Yvonne Roger, Heike Bunjes, Andrea Hoffmann
Summary: The design of implants for tissue transitions is challenging, and the rotator cuff in the shoulder is an example of such a transition. Electrospun fiber mats of PCL loaded with CS/TPP nanoparticles and TGF-beta(3) were used to optimize the implant for enthesis regeneration. Higher loading concentrations of TGF-beta(3) led to increased release, larger cell pellets, and enhanced chondrogenic differentiation of MSCs.
Article
Biochemistry & Molecular Biology
Alexander J. Choi, Brenna S. Hefley, Sarah E. Nicholas, Rebecca L. Cunningham, Dimitrios Karamichos
Summary: This study investigated the interplay between transforming growth factor beta and sex hormone receptors using a 3D in vitro cornea stroma model, and found that this interplay is influenced by sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jikai Cui, Heng Xu, Jizhang Yu, Yuan Li, Zhang Chen, Yanqiang Zou, Xi Zhang, Yifan Du, Jiahong Xia, Jie Wu
Summary: Regulatory T cells differentiation is inhibited by IL-4 through epigenetic modulations. HDAC9 is involved in histone deacetylation process, affecting Foxp3 gene transcription, while sodium butyrate can abolish the inhibitory effects of IL-4.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Kathrin Klaesener, Julia Jellusova, Geoffroy Andrieux, Ulrich Salzer, Chiara Boehler, Sebastian N. Steiner, Jonas B. Albinus, Marco Cavallari, Beatrix Suess, Reinhard E. Voll, Melanie Boerries, Bernd Wollscheid, Michael Reth
Summary: CD20 regulates the nanoscale organization of receptors on resting B lymphocytes, and its disruption leads to B cell activation and internalization of membrane proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Abigael E. Chaouat, Ilija Brizic, Paola Kucan Brlic, Nofar Atari, Limor Kliker, Or Alfi, Michal Mandelboim, Dana Wolf, Laith Tafish, Inbal Kol, Stipan Jonjic, Ofer Mandelboim
Summary: The global pandemic caused by SARS-CoV-2 is a major public health problem. The emergence of the Omicron variant poses a challenge to existing treatments, leading to the urgent need for new therapeutic options. The hACE2.16 antibody has been found to effectively block infection and virus production of various VOCs, including Omicron.
Article
Medical Laboratory Technology
Zhen Shi, Jianguo Xu, Qiang Jia, Jinsong Zhou, Dong Yang, Yan Zhao
Summary: This study reveals the significant role of TGF-beta 3 in the chondrogenic differentiation of bone marrow mesenchymal stem cells and confirms let-7a-3p as a target of TGF-beta 3, which inhibits the process of chondrogenic differentiation.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Ehtesham Arif, Cindy Wang, Marzena K. Swiderska-Syn, Ashish K. Solanki, Bushra Rahman, Paul P. Manka, Jason D. Coombes, Ali Canbay, Salvatore Papa, Deepak Nihalani, Patricia Aspichueta, Joshua H. Lipschutz, Wing-Kin Syn
Summary: Myo1c plays a crucial role in hepatic fibrogenesis by modulating TGF-b signaling. Genetic deletion or pharmacological inhibition of Myo1c can attenuate fibrogenic responses, presenting a potential clinical application in treating liver fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minghui Chen, Xi Guo, Yiping Zhong, Yang Liu, Bing Cai, Rihan Wu, Chuan Huang, Canquan Zhou
Summary: This study revealed that AMH can inhibit androgen synthesis in human theca cells, especially in PCOS. It was also found that ALK2 and ALK5 may be involved in the inhibitory effect of AMH.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Natsumi Saito, Akiko Kikuchi, Mutsuo Yamaya, Xue Deng, Mitsuru Sugawara, Shin Takayama, Ryoichi Nagatomi, Tadashi Ishii
Summary: Kakkonto extract can reduce the production of specific pro-inflammatory cytokines in response to rhinovirus (RV) infection, suggesting its potential as an effective therapy to inhibit inflammation caused by RV and subsequent airway inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Ilona Uzieliene, Edvardas Bagdonas, Kazuto Hoshi, Tomoaki Sakamoto, Atsuhiko Hikita, Zivile Tachtamisevaite, Greta Rakauskiene, Giedrius Kvederas, Ali Mobasheri, Eiva Bernotiene
Summary: This study evaluated the chondrogenic differentiation potential of MenSCs and BMMSCs, finding that activin A had a promoting effect on chondrogenic differentiation in MenSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Immunology
Nina M. de Gruijter, Bethany Jebson, Elizabeth C. Rosser
Summary: B cells, traditionally known for antibody production, are now recognized for their secretion of cytokines that influence immune responses in both pro- and anti-inflammatory ways.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Ying Fu, Zhiming Wang, Baichao Yu, Yuli Lin, Enyu Huang, Ronghua Liu, Chujun Zhao, Mingfang Lu, Wei Xu, Hongchun Liu, Yongzhong Liu, Luman Wang, Yiwei Chu
Summary: The study reveals that CD11b(+) B cells play a crucial role in alleviating colitis and producing IgA, with CD11b deficiency leading to loss of this protective function. CD11b(+) B cells promote class switch to IgA by expressing abundant TGF-beta and TGF-beta receptor II.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hui Li, Hsun-Ming Chang, Yung-Ming Lin, Zhendan Shi, Peter C. K. Leung
Summary: This study suggests that TGF-beta 1 may upregulate the expression of SNAIL transcription factor, leading to a suppression of VCAM1 and ICAM1 in hGL cells, thereby inhibiting granulosa cell angiogenesis. The inhibitory effects of TGF-beta 1 on VCAM1 and ICAM1 expression may be mediated through an ALK5-dependent SMAD signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Rheumatology
Masataka Kuwana, Naoto Tamura, Shinsuke Yasuda, Keishi Fujio, Ayako Shoji, Hiroko Yamaguchi, Katsuhiko Iwasaki, Misako Makishima, Yuichi Kawata, Katsuhisa Yamashita, Ataru Igarashi
Summary: This study assessed the cost-effectiveness of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) in the treatment of rheumatoid arthritis. The results showed that b/tsDMARDs with lower prices demonstrated higher cost-effectiveness.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Yukiko Iwasaki, Yusuke Takeshima, Masahiro Nakano, Mai Okubo, Mineto Ota, Akari Suzuki, Yuta Kochi, Tomohisa Okamura, Takaho Endo, Ichiro Miki, Kazuhiro Sakurada, Kazuhiko Yamamoto, Keishi Fujio
Summary: This study explored the potential of plasma histidine levels as biomarkers for SLE patients. The results showed that histidine, along with other amino acids, could effectively distinguish between SLE patients and healthy controls. Furthermore, a decrease in histidine levels correlated with disease damage accrual, suggesting its involvement in SLE pathogenesis.
Article
Immunology
Kazuki M. Matsuda, Hirohito Kotani, Kei Yamaguchi, Taishi Okumura, Eriko Fukuda, Masanori Kono, Teruyoshi Hisamoto, Ruriko Kawanabe, Yuta Norimatsu, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Summary: Cutaneous arteritis (CA) is a skin vasculitis that affects small to medium-sized arteries. The diagnosis relies on skin biopsy, which can be burdensome. The pathogenesis and treatment of CA are still unclear. In this study, anti-transcobalamin receptor (TCblR) antibodies were found in 24% of CA patients and were associated with skin-limited CA. These antibodies trigger interleukin-6 autocrine loop and induce periarterial inflammation. Methylcobalamin, a ligand of TCblR, can ameliorate inflammation caused by these antibodies. These findings suggest that anti-TCblR antibodies could be a diagnostic marker and a therapeutic target for CA.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Saeko Yamada, Yasuo Nagafuchi, Min Wang, Mineto Ota, Hiroaki Hatano, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Nakano Masahiro, Ryochi Yoshida, Norio Hanata, Yuichi Suwa, Yumi Tsuchida, Yukiko Iwasaki, Shuji Sumitomo, Kanae Kubo, Kenichi Shimane, Keigo Setoguchi, Takanori Azuma, Hiroko Kanda, Hirofumi Shoda, Xuan Zhang, Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Tomohisa Okamura, Keishi Fujio
Summary: By analyzing the transcriptome of peripheral blood immune cell subsets in patients with rheumatoid arthritis (RA), immune cells that predict treatment resistance were identified. Changes in the transcriptome and treatment effects in RA were characterized. Plasmacytoid dendritic cells (pDC) showed the strongest association with treatment resistance. The predictive value of pDC-related gene expression and pDC proportion in treatment-resistant patients was validated in independent cohorts.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Yumi Tsuchida, Hirofumi Shoda, Tetsuji Sawada, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by the production of autoantibodies and immune complex deposition. Autotaxin (ATX), which catalyzes the production of lysophosphatidic acid, has been identified as a potential biomarker in SLE. Increased levels of ATX have been found in the serum and urine of patients with SLE and lupus nephritis. Recent studies suggest that ATX produced by plasmacytoid dendritic cells may have an important role in SLE pathogenesis, and it is associated with type I interferons. ATX may be a valuable biomarker and key molecule in SLE.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Hideki Oka, Shuji Sumitomo, Hayato Shimizu, Maki Kanamori, Shiori Murata, Daisuke Yamashita, Taiji Okada, Hiroaki Nishioka, Koichiro Ohmura
Summary: This case report reveals the relationship between anti-synthetase syndrome and pulmonary artery hypertension, as well as malignancy.
Article
Immunology
Bunki Natsumoto, Hirofumi Shoda, Yasuo Nagafuchi, Mineto Ota, Takashi Okumura, Yumi Horie, Tomohisa Okamura, Kazuhiko Yamamoto, Motonori Tsuji, Makoto Otsu, Hideki Taniguchi, Keishi Fujio
Summary: In this study, patient-derived induced pluripotent stem cells (iPSCs) were used in combination with genetic analysis to identify and elucidate the biological functions of rare variants underlying systemic lupus erythematosus (SLE). It was found that a rare variant in the OASL gene was shared between SLE-iPSCs and another independent SLE patient, and there was a significant accumulation of OASL variants among SLE patients. Additionally, genome editing experiments confirmed the impact of these variants on type 1 interferon secretion in immune cells.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Sotaro Nakajima, Haruka Tsuchiya, Mineto Ota, Megumi Ogawa, Saeko Yamada, Ryochi Yoshida, Junko Maeda, Harumi Shirai, Taro Kasai, Jun Hirose, Keita Ninagawa, Yuichiro Fujieda, Takeshi Iwasaki, Yoshimi Aizaki, Hiroshi Kajiyama, Masakazu Matsushita, Eiryo Kawakami, Naoto Tamura, Toshihide Mimura, Koichiro Ohmura, Akio Morinobu, Tatsuya Atsumi, Yoshiya Tanaka, Tsutomu Takeuchi, Sakae Tanaka, Tomohisa Okamura, Keishi Fujio
Summary: This study utilized single-cell RNA sequencing technology to stratify and analyze the synovium of East Asian patients with rheumatoid arthritis (RA), revealing the heterogeneity of immune cell compositions and providing insights into the inflammatory drivers. The findings highlight the potential of evaluating the site of inflammation for personalized drug selection.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Yusuke Sugimori, Yukiko Iwasaki, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Kenichi Shimane, Ken Yoshida, Daitaro Kurosaka, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
Summary: Transcriptome analysis identified common or specific immunological pathways in different immune cell types of patients with idiopathic inflammatory myopathies (IIM) based on their clinical phenotypes and myositis-specific antibodies (MSAs). B cells may play a significant role in both common and specific immunological pathways in IIM.
ACR OPEN RHEUMATOLOGY
(2023)
Letter
Rheumatology
T. Komai, T. Sawada, H. Tsuchiya, H. Harada, H. Shoda, K. Fujio
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Shinji Izuka, Toshihiko Komai, Hirofumi Shoda, Keishi Fujio
Summary: This study found that patients with myositis-specific antibody (MSA)-positive idiopathic inflammatory myopathy (IIM), specifically those with anti-MDA5 and anti-TIF1-gamma antibodies, have an increased long-term risk of malignancy. Screening for malignancies in patients with late phase of IIM and an anti-MDA5 antibody may be beneficial.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Daichi Umemoto, Shuji Sumitomo, Shohei Fujita, Hayato Shimizu, Hideki Oka, Maki Kanamori, Hiroaki Nishioka, Koichiro Ohmura
Summary: Patients with abnormally high anti-MDA-5 antibody titres may experience disease progression even if ferritin levels are not high and lung shadows are minimal. Therefore, early intensive treatment is necessary regardless of serum ferritin level.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Rheumatology
Hideki Oka, Shuji Sumitomo, Hayato Shimizu, Maki Kanamori, Daisuke Yamashita, Hiroaki Nishioka, Koichiro Ohmura
Summary: An 86-year-old man who had undergone endovascular aortic repair for an abdominal aortic aneurysm with impending rupture presented to the hospital due to fatigue and black stools. The diagnosis of aortic duodenal fistula was confirmed and emergency abdominal aortic replacement was performed. Pathological findings revealed the presence of numerous IgG4-positive plasma cells infiltrating the aortic wall, leading to a diagnosis of IgG4-related periaortitis.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
