Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding
Published 2016 View Full Article
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Title
Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 291, Issue 20, Pages 10792-10804
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2016-03-10
DOI
10.1074/jbc.m115.713487
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- Signaling by the TGF Superfamily
- (2013) J. L. Wrana Cold Spring Harbor Perspectives in Biology
- The Harmonies Played by TGF-β in Stem Cell Biology
- (2012) Naoki Oshimori et al. Cell Stem Cell
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- (2012) Laia Caja et al. CURRENT PHARMACEUTICAL DESIGN
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