JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

The transcription factor JunD mediates transforming growth factor  -induced fibroblast activation and fibrosis in systemic sclerosis

(2011) K. Palumbo et al.   ANNALS OF THE RHEUMATIC DISEASES

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

(2011) C. Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Platelet-derived serotonin links vascular disease and tissue fibrosis

(2011) Clara Dees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

(2011) Ryan C Russell et al.   NATURE MEDICINE

Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

(2010) A. J. Tyndall et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis

(2010) Sieglinde Marquart et al.   ARTHRITIS AND RHEUMATISM

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

JAK2 inhibitors: What's the true therapeutic potential?

(2010) Fabio P.S. Santos et al.   BLOOD REVIEWS

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Inhibition of JAK–STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells

(2010) T Lasho et al.   LEUKEMIA

JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations

(2010) A Pardanani et al.   LEUKEMIA

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells

(2009) Y. Wang et al.   BLOOD

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic potential of JAK2 inhibitors

(2009) S. Verstovsek   Hematology-American Society of Hematology Education Program

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

(2008) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells

(2008) Yonghong Shi et al.   FEBS LETTERS

Pulmonary rehabilitation in idiopathic pulmonary fibrosis: A call for continued investigation

(2008) Jeffrey J. Swigris et al.   RESPIRATORY MEDICINE

Review: Therapies for interstitial lung disease: past, present and future

(2008) Robert Kim et al.   Therapeutic Advances in Respiratory Disease