Non-Smad signaling pathways

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

(2011) Xiaohua Yan et al.   BIOCHEMICAL JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Monomeric type I and type III transforming growth factor-β receptors and their dimerization revealed by single-molecule imaging

(2010) Wei Zhang et al.   CELL RESEARCH

Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition

(2010) Samy Lamouille et al.   CELLS TISSUES ORGANS

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

The TAK1–TRAF6 signalling pathway

(2010) Marene Landström   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1

(2010) Anita Morén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction

(2010) Yuto Kamiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

(2010) Lars P. van der Heide et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T RI/Alk5-independent T RII signaling to ERK1/2 in human skin cells according to distinct levels of T RII expression

(2010) B. Bandyopadhyay et al.   JOURNAL OF CELL SCIENCE

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo

(2010) Kyle A. DiVito et al.   Pigment Cell & Melanoma Research

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of the immune response by stress-activated protein kinases

(2009) Mercedes Rincón et al.   IMMUNOLOGICAL REVIEWS

Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells

(2009) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

Single-molecule imaging reveals transforming growth factor- -induced type II receptor dimerization

(2009) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Suppression by LKB1: SIK-ness Prevents Metastasis

(2009) R. J. Shaw   Science Signaling

SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis

(2009) H. Cheng et al.   Science Signaling

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Altered TAB1:I B Kinase Interaction Promotes Transforming Growth Factor  -Mediated Nuclear Factor- B Activation during Breast Cancer Progression

(2008) J. R. Neil et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Ectodermal Smad4 and p38 MAPK Are Functionally Redundant in Mediating TGF-β/BMP Signaling during Tooth and Palate Development

(2008) Xun Xu et al.   DEVELOPMENTAL CELL

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

(2008) Anne Gingery et al.   EXPERIMENTAL CELL RESEARCH

Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway

(2008) Dmitri V. Pechkovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

(2008) Marcin Kowanetz et al.   JOURNAL OF CELL BIOLOGY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Integrin α3β1 Potentiates TGFβ-Mediated Induction of MMP-9 in Immortalized Keratinocytes

(2007) John M. Lamar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY