Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy
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Title
Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-05-20
DOI
10.3389/fonc.2020.00792
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Note: Only part of the references are listed.- Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
- (2019) Minhong Shen et al. CANCER CELL
- Snail-induced claudin-11 prompts collective migration for tumour progression
- (2019) Ching-Fei Li et al. NATURE CELL BIOLOGY
- Vimentin-positive circulating tumor cells as a biomarker for diagnosis and treatment monitoring in patients with pancreatic cancer
- (2019) Tao Wei et al. CANCER LETTERS
- Context-dependent EMT programs in cancer metastasis
- (2019) Nicole M. Aiello et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Tumor Metabolic Microenvironment: Lessons from Lactate
- (2019) Juan C. García-Cañaveras et al. CANCER RESEARCH
- Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS ‐mutated human colorectal cancer cells
- (2019) Yuta Hara et al. Cancer Medicine
- Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma
- (2018) G K Abou-Alfa et al. ANNALS OF ONCOLOGY
- Epithelial-mesenchymal transition in human prostate cancer demonstrates enhanced immune evasion marked by IDO1 expression
- (2018) Kimberley Kolijn et al. CANCER RESEARCH
- As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
- (2018) Natalya N. Pavlova et al. Cell Metabolism
- Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer
- (2018) Simon R. V. Knott et al. NATURE
- Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
- (2018) Courtney D. DiNardo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
- (2018) James S.V. Lally et al. Cell Metabolism
- The Role of PPARβ/δ in Melanoma Metastasis
- (2018) Jonathan Lim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
- (2018) Li Wang et al. Nature Communications
- A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models
- (2018) Stephen B. Willingham et al. Cancer Immunology Research
- Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin
- (2018) Meng-Ju Wu et al. Cell Metabolism
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- (2018) Gunnar Boysen et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- The multiverse nature of epithelial to mesenchymal transition
- (2018) Pasquale Simeone et al. SEMINARS IN CANCER BIOLOGY
- Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
- (2017) Richard A. Noble et al. HAEMATOLOGICA
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells
- (2017) Chun-Yan Xu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial
- (2017) Angela Alistar et al. LANCET ONCOLOGY
- Emerging roles of lipid metabolism in cancer metastasis
- (2017) Xiangjian Luo et al. Molecular Cancer
- Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
- (2017) Rodrigo Romero et al. NATURE MEDICINE
- Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure
- (2017) Eunyoung Tak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress
- (2017) Nam Hee Kim et al. Nature Communications
- Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
- (2017) Alexander Muir et al. eLife
- Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
- (2017) Richard A. Noble et al. HAEMATOLOGICA
- Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
- (2016) Arabella Young et al. CANCER CELL
- High-throughput Phenotyping of Lung Cancer Somatic Mutations
- (2016) Alice H. Berger et al. CANCER CELL
- Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells
- (2016) Tsang-Chih Kuo et al. CANCER LETTERS
- Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
- (2016) Kimberly S. Lucenay et al. CANCER RESEARCH
- Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
- (2016) D. Mittal et al. CANCER RESEARCH
- Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity
- (2016) Weina Zhao et al. CANCER RESEARCH
- EMT: 2016
- (2016) M. Angela Nieto et al. CELL
- Prognostic significance of monocarboxylate transporter expression in oral cavity tumors
- (2016) Susana Simões-Sousa et al. CELL CYCLE
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- Metabolic regulation of mitochondrial dynamics
- (2016) Prashant Mishra et al. JOURNAL OF CELL BIOLOGY
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth
- (2016) Lei Jiang et al. NATURE
- Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
- (2016) Robert U Svensson et al. NATURE MEDICINE
- Arginine dependence of tumor cells: targeting a chink in cancer’s armor
- (2016) M D Patil et al. ONCOGENE
- Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-β1 by attenuating the upregulation of SphK1
- (2016) Zhiqiang Fan et al. ONCOLOGY REPORTS
- Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis
- (2016) Yulin Liu et al. PLoS One
- A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer
- (2016) Li Yang et al. Oncotarget
- Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop
- (2016) Ye Zeng et al. Oncotarget
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- (2015) N. Jacque et al. BLOOD
- Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer
- (2015) H Ueo et al. BRITISH JOURNAL OF CANCER
- Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
- (2015) An S. Tan et al. Cell Metabolism
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- (2015) Younghye Kim et al. HUMAN PATHOLOGY
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- (2015) Mohamed Hassanein et al. INTERNATIONAL JOURNAL OF CANCER
- Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma
- (2015) Thomas Yau et al. INVESTIGATIONAL NEW DRUGS
- Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
- (2015) Yan Xiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
- (2015) Qian Wang et al. JOURNAL OF PATHOLOGY
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- Oxidative stress inhibits distant metastasis by human melanoma cells
- (2015) Elena Piskounova et al. NATURE
- Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid
- (2015) K Kitatani et al. ONCOGENE
- ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
- (2015) M van Geldermalsen et al. ONCOGENE
- Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages
- (2014) Dennis Shin-Shian Hsu et al. CANCER CELL
- Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
- (2014) Yoav D. Shaul et al. CELL
- Epithelial-Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression
- (2014) A. Satelli et al. CLINICAL CANCER RESEARCH
- Targeting glutamine transport to suppress melanoma cell growth
- (2014) Qian Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer
- (2014) S H-S Lim et al. JOURNAL OF CLINICAL PATHOLOGY
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells
- (2014) Wei-Lun Hwang et al. NATURE CELL BIOLOGY
- Oncogenic roles of EMT-inducing transcription factors
- (2014) Alain Puisieux et al. NATURE CELL BIOLOGY
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas
- (2014) T Gelb et al. ONCOGENE
- Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
- (2014) N Cetinbas et al. ONCOGENE
- Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
- (2014) L Jiang et al. ONCOGENE
- Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition
- (2014) Danielle B. Ulanet et al. PLoS One
- Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
- (2014) Takehiro Yamamoto et al. Nature Communications
- Regulation of the pentose phosphate pathway in cancer
- (2014) Peng Jiang et al. Protein & Cell
- Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
- (2014) Meera Rath et al. Frontiers in Immunology
- Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
- (2014) Lorena Pochini et al. Frontiers in Chemistry
- Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
- (2013) Chenfang Dong et al. CANCER CELL
- Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis
- (2013) T. Yokobori et al. CANCER RESEARCH
- CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells
- (2013) Denise K Walters et al. CELL CYCLE
- Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs
- (2013) Samy Lamouille et al. CURRENT OPINION IN CELL BIOLOGY
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
- (2013) M. A. Nieto SCIENCE
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism
- (2012) S. Y. Lee et al. CANCER RESEARCH
- Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming
- (2012) Shuo Qie et al. CELL CYCLE
- An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
- (2012) L. A. Byers et al. CLINICAL CANCER RESEARCH
- Mitochondrial Fission, Fusion, and Stress
- (2012) R. J. Youle et al. SCIENCE
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
- (2011) Adam T. Waickman et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Direct reprogramming of stem cell properties in colon cancer cells by CD44
- (2011) Ying-Jhen Su et al. EMBO JOURNAL
- Targeting methionine auxotrophy in cancer: discovery & exploration
- (2011) Vaidehi Agrawal et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells
- (2011) Wei–Lun Hwang et al. GASTROENTEROLOGY
- Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
- (2011) Zuzana Zachar et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
- (2011) Ligia C. Gomes et al. NATURE CELL BIOLOGY
- Targeting cancer metabolism: a therapeutic window opens
- (2011) Matthew G. Vander Heiden NATURE REVIEWS DRUG DISCOVERY
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- (2011) D. Anastasiou et al. SCIENCE
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer
- (2010) D. S.-S. Hsu et al. CLINICAL CANCER RESEARCH
- The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?
- (2010) Simone Brabletz et al. EMBO REPORTS
- Invasion and EMT-associated genes are up-regulated in B viral hepatocellular carcinoma with high expression of CD133-human and cell culture study
- (2010) Deuk Chae Na et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
- (2010) Barbara Delage et al. INTERNATIONAL JOURNAL OF CANCER
- Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition
- (2010) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
- Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A
- (2010) Carmela De Santo et al. NATURE IMMUNOLOGY
- Extracellular adenosine triphosphate and adenosine in cancer
- (2010) J Stagg et al. ONCOGENE
- Correction for Taube et al., Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
- (2010) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EMT, the cytoskeleton, and cancer cell invasion
- (2009) Mahmut Yilmaz et al. CANCER AND METASTASIS REVIEWS
- Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells
- (2009) H. Yamaguchi et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
- (2009) Zachary T. Schafer et al. NATURE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer
- (2008) Edward W. Howard et al. CLINICAL & EXPERIMENTAL METASTASIS
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor
- (2008) N. Herranz et al. MOLECULAR AND CELLULAR BIOLOGY
- Direct regulation of TWIST by HIF-1α promotes metastasis
- (2008) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
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