ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

(2017) Anne-Pierre Morel et al.   NATURE MEDICINE

The DNA damage response: Balancing the scale between cancer and ageing

(2016) Elena G. Seviour et al.   Aging-US

Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner

(2015) Ancheng Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

Expression of epithelial-mesenchymal transition–related markers in triple-negative breast cancer: ZEB1 as a potential biomarker for poor clinical outcome

(2015) Min Hye Jang et al.   HUMAN PATHOLOGY

miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin

(2015) X Zhu et al.   ONCOGENE

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation

(2015) Urszula Liwak et al.   Oncotarget

Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation

(2014) Hong Qiong Yan et al.   CANCER SCIENCE

MicroRNA-141 and MicroRNA-146b-5p Inhibit the Prometastatic Mesenchymal Characteristics through the RNA-binding Protein AUF1 Targeting the Transcription Factor ZEB1 and the Protein Kinase AKT

(2014) Huda H. Al-Khalaf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism

(2014) Yanan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

(2014) Yihua Wang et al.   NATURE CELL BIOLOGY

ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors

(2014) S Mohanty et al.   Cell Death & Disease

CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression

(2013) Yunshan Wang et al.   CANCER RESEARCH

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway

(2013) Zhilan Chen et al.   HUMAN PATHOLOGY

Epithelial–mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells

(2013) Song-Ze Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

(2012) Lionel Flamant et al.   BMC CANCER

Functional Analysis of the ATM-p53-p21 Pathway in the LRF CLL4 Trial: Blockade at the Level of p21 Is Associated with Short Response Duration

(2012) K. Lin et al.   CLINICAL CANCER RESEARCH

Cooperation of p300 and PCAF in the Control of MicroRNA 200c/141 Transcription and Epithelial Characteristics

(2012) Yoshiaki Mizuguchi et al.   PLoS One

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

Clinical significance of zinc finger E-box binding homeobox 1 (ZEB1) in human gastric cancer

(2011) Yoshinaga Okugawa et al.   JOURNAL OF SURGICAL ONCOLOGY

Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis

(2011) Mohammad H Forouzanfar et al.   LANCET

Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer

(2010) D. S.-S. Hsu et al.   CLINICAL CANCER RESEARCH

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

δEF1 promotes breast cancer cell proliferation through down-regulating p21 expression

(2009) Fen Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY