Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 235, Issue 12, Pages 8983-8995Publisher
WILEY
DOI: 10.1002/jcp.29828
Keywords
cancer-associated fibroblasts; collective invasion; EMT; leader cell; microenvironment
Categories
Funding
- National Natural Science Foundation of China [21838002, 81672672, 81972542]
- National Key R&D Program of China [2019YFA09005700]
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Cancer cells collectively invading as a cohesive and polarized group is termed collective invasion, which is a fundamental property of many types of cancers. In this multicellular unit, cancer cells are heterogeneous, consisting of two morphologically and functionally distinct subpopulations, leader cells and follower cells. Leader cells at the invasive front are responsible for exploring the microenvironment, paving the way, and transmitting information to follower cells. Here, in this review, we will describe the important role of leader cells in collective invasion and the emerging underlying mechanisms of leader cell formation including intrinsic properties and the support from neighboring cells. It will help us to elucidate the essence of collective invasion and provide new anticancer therapeutic clues.
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