Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse

Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

(2018) Magda R. Hamczyk et al.   CIRCULATION

Echocardiographic evaluation of diastolic function in mouse models of heart disease

(2018) Moritz Schnelle et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome

(2018) Ashwin Prakash et al.   JAMA Cardiology

Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications

(2016) Adam Harvey et al.   CANADIAN JOURNAL OF CARDIOLOGY

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks

(2015) S. Osmanagic-Myers et al.   JOURNAL OF CELL SCIENCE

Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy

(2015) Xinyu Weng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy

(2015) Xinyu Weng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Vascular biology of ageing—Implications in hypertension

(2015) Adam Harvey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

Age-related vascular stiffening: causes and consequences

(2015) Julie C. Kohn et al.   Frontiers in Genetics

Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase

(2014) Ramzi N. El Accaoui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Cell adhesion molecules and eNOS expression in aorta of normocholesterolemic mice with different predispositions to atherosclerosis

(2014) Jana Rathouska et al.   HEART AND VESSELS

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

(2014) Jean-Ha Baek et al.   HUMAN MOLECULAR GENETICS

Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies

(2014) Z.-J. Chen et al.   JOURNAL OF CELL SCIENCE

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1

(2014) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

(2014) Nicolas Baeyens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

(2013) Ricardo Villa-Bellosta et al.   CIRCULATION

Mechanosensing through focal adhesion-anchored intermediate filaments

(2013) Martin Gregor et al.   FASEB JOURNAL

Snail as a Potential Target Molecule in Cardiac Fibrosis: Paracrine Action of Endothelial Cells on Fibroblasts Through Snail and CTGF Axis

(2013) Sae-Won Lee et al.   MOLECULAR THERAPY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

High Glucose Attenuates Shear-Induced Changes in Endothelial Hydraulic Conductivity by Degrading the Glycocalyx

(2013) Sandra V. Lopez-Quintero et al.   PLoS One

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

(2013) Allison B. Chambliss et al.   Scientific Reports

Endothelial actions of atrial and B-type natriuretic peptides

(2012) Michaela Kuhn   BRITISH JOURNAL OF PHARMACOLOGY

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice

(2012) Takeya Minami et al.   EMBO JOURNAL

Expression of the Hutchinson-Gilford Progeria Mutation during Osteoblast Development Results in Loss of Osteocytes, Irregular Mineralization, and Poor Biomechanical Properties

(2012) Eva Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure

(2012) Zhehao Dai et al.   Journal of Cardiology

Progeria: Translational insights from cell biology

(2012) Leslie B. Gordon et al.   JOURNAL OF CELL BIOLOGY

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

(2011) Fei Fang et al.   CIRCULATION RESEARCH

Mechanisms of Premature Vascular Aging in Children With Hutchinson-Gilford Progeria Syndrome

(2011) Marie Gerhard-Herman et al.   HYPERTENSION

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stiffening of Human Skin Fibroblasts with Age

(2010) Christian Schulze et al.   BIOPHYSICAL JOURNAL

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

Hemodynamic forces in endothelial dysfunction and vascular aging

(2010) Caitlin Collins et al.   EXPERIMENTAL GERONTOLOGY

Mechanobiology and the Microcirculation: Cellular, Nuclear and Fluid Mechanics

(2010) KRIS NOEL DAHL et al.   MICROCIRCULATION

eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

(2009) J.-L. Balligand et al.   PHYSIOLOGICAL REVIEWS

Dysfunctional Connections Between the Nucleus and the Actin and Microtubule Networks in Laminopathic Models

(2008) Christopher M. Hale et al.   BIOPHYSICAL JOURNAL

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging

(2008) Julia T. Philip et al.   JOURNAL OF BIOMECHANICS

Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

(2008) H. Sagelius et al.   JOURNAL OF CELL SCIENCE

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

(2008) Peter F Davies   Nature clinical practice. Cardiovascular medicine