Review
Biochemistry & Molecular Biology
Alan Rawls, Bridget K. Diviak, Cameron I. Smith, Grant W. Severson, Sofia A. Acosta, Jeanne Wilson-Rawls
Summary: Muscular dystrophies are genetic muscle-wasting disorders characterized by chronic inflammation and fibrotic scarring in muscle tissue. Duchenne muscular dystrophy, the most common form, is typically treated with anti-inflammatory glucocorticoids; however, their long-term use is limited by adverse side effects. Developing new pharmacotherapeutic approaches to reduce muscle damage and promote repair is crucial.
Article
Biochemistry & Molecular Biology
Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Floris A. Valentijn, Antonio Tejera-Munoz, Sandra Rayego-Mateos, Vanessa Marchant, Raul R. Rodrigues-Diez, Irene Rubio-Soto, Sebastiaan N. Knoppert, Alberto Ortiz, Adrian M. Ramos, Roel Goldschmeding, Marta Ruiz-Ortega
Summary: Chronic kidney disease (CKD) is regarded as a clinical model for premature aging. This study aimed to investigate the age-related activation of cellular senescence-associated mechanisms and their correlation with early structural changes in the kidney. The findings suggest that early activation of cellular senescence-associated mechanisms could be early drivers of age-related kidney damage progression.
Article
Biochemistry & Molecular Biology
Shingo Urate, Hiromichi Wakui, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Yoshitoshi Atobe, Kengo Funakoshi, Akio Yamashita, Kouichi Tamura
Summary: The study on the induction of renal aging by aristolochic acid demonstrates that kidneys show aging phenotypes, increased cellular senescence, proximal tubular mitochondrial abnormalities, decreased antiaging gene Klotho, leading to renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Mas-Bargues
Summary: Aging is a complex biological process characterized by the decline in cellular and tissue function. Stem cells and mitochondria play important roles in this process, influencing tissue function and aging. This review discusses the mechanisms through which mitochondria impact stem cell fate decisions and explores potential anti-aging therapies targeting mitochondrial health.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Geriatrics & Gerontology
Yuan Li, Nia T. Adeniji, Weiguo Fan, Koshi Kunimoto, Natalie J. Torok
Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have become the leading causes of chronic liver disease-related mortality, with a growing prevalence due to obesity and type 2 diabetes mellitus epidemics. Older patients are particularly affected by NASH and its complications, but are often ineligible for liver transplantation and lack effective medical treatments. Understanding the pathways involved in liver aging and NAFLD/NASH will be crucial for designing novel therapeutic strategies for elderly patients.
Review
Biochemistry & Molecular Biology
Jason Llaneras, Caitlyn C. Belza, Samuel Eisenstein, Marek K. Dobke
Summary: Senescent cells and fibrosis impact the regenerative capacity of skin, particularly in chronic non-healing wounds. This study explores potential senescence reversing techniques and proposes the use of exosomes loaded with senolytics for improving chronic wound healing.
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Sacco, Laura Belloni, Lucia Latella
Summary: Senescence is a cellular state induced by internal or external stimuli, resulting in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality. Recent evidence suggests that senescent cells in vivo are a heterogeneous cell population due to different activated pathways and distinct microenvironmental contexts. Future research will focus on exploring the heterogeneity of senescent cells to map cell progression and study the therapeutic advantages of senolytic drugs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Pharmacology & Pharmacy
Yuki Saito, Takako S. S. Chikenji
Summary: Senescent cells play both beneficial and detrimental roles in tissue regeneration, aging, and disease development. Accumulation of senescent cells may lead to progressive tissue degeneration. Targeting senescent cells for therapy could potentially improve muscle regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Summary: Advanced age is a shared risk factor for chronic skeletal diseases. The senescence of mesenchymal stem cells (MSCs) exacerbates inflammatory microenvironment and disrupts bone remodeling, contributing to age-related bone diseases. Understanding the molecular and epigenetic mechanisms of MSC senescence, such as oxidative stress and mitochondrial dysfunction, could present rejuvenation strategies for skeletal aging restoration.
Article
Multidisciplinary Sciences
Ing-Shiow Lay, Wei-Wen Kuo, Marthandam Asokan Shibu, Tsung-Jung Ho, Shiu-Min Cheng, Cecilia Hsuan Day, Bo Ban, Shulin Wang, Qiaowen Li, Chih-Yang Huang
Summary: This study evaluated the impact of long-term exercise training on the cardiac survival mechanism in D-galactose-induced aging rats, revealing elevated IGF1R/Akt signaling in rats subjected to exercise training and restoration of cardiac survival proteins levels.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Jazmin Calyeca, Yalbi Balderas-Martinez, Moises Selman, Annie Pardo
Summary: This study revealed that aged mice lungs showed enriched signaling pathways related to cell apoptosis, senescence, development, oxidative stress, and inflammation. Additionally, 25 miRNAs in the lungs of old mice were significantly different compared to their younger littermates, with eight upregulated and 17 downregulated. This suggests that old lungs have increased susceptibility to apoptosis, inflammation, and fibrosis.
Article
Immunology
Yingze Li, Guojian Fang, Wei Cao, Jiali Yuan, Shuai Song, Hong Peng, Yuepeng Wang, Qunshan Wang
Summary: In the aged and fibrotic left atrium, replicative senescence of atrial fibroblasts (AFs) plays a significant role in the pathogenesis of atrial fibrillation. The downregulation of Ezh2, a histone methyltransferase, is identified as a key regulator of AFs' replicative senescence. This finding may have implications for future treatments of atrial fibrosis in the elderly.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
ZuFu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang, Colin R. Dunstan, XinQuan Jiang, Hala Zreiqat
Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Neill Storrar, Eve Miller-Hodges, John Neary, Jeremy Hughes, Nicole Priddee
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Article
Immunology
Katie J. Mylonas, Jennifer Anderson, Tara A. Sheldrake, Emily E. Hesketh, James A. Richards, David A. Ferenbach, David C. Kluth, John Savill, Jeremy Hughes
Letter
Urology & Nephrology
Eoin D. O'Sullivan, Katie J. Mylonas, Jeremy Hughes, David A. Ferenbach
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Physiology
James O'Sullivan, Sarah Louise Finnie, Oliver Teenan, Carolynn Cairns, Andrew Boyd, Matthew A. Bailey, Adrian Thomson, Jeremy Hughes, Cecile Benezech, Bryan Ronald Conway, Laura Denby
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Urology & Nephrology
Rachael Logan, Peter Davey, Nicosha De Souza, David Baird, Bruce Guthrie, Samira Bell
CLINICAL KIDNEY JOURNAL
(2020)
Article
Urology & Nephrology
Bryan R. Conway, Eoin D. O'Sullivan, Carolynn Cairns, James O'Sullivan, Daniel J. Simpson, Angela Salzano, Katie Connor, Peng Ding, Duncan Humphries, Kevin Stewart, Oliver Teenan, Riinu Pius, Neil C. Henderson, Cecile Benezech, Prakash Ramachandran, David Ferenbach, Jeremy Hughes, Tamir Chandra, Laura Denby
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
David Baird, Nicosha De Souza, Rachael Logan, Heather Walker, Bruce Guthrie, Samira Bell
Summary: The introduction of automated AKI e-alerts in the Tayside region of UK did not lead to changes in the rate, severity, or mortality associated with AKI, but there was a slight reduction in occupied hospital bed days.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
David P. Baird, Jac Williams, Michaela C. Petrie, James R. Smith
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Medicine, Research & Experimental
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A. B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O. S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Article
Cell Biology
Katie J. Mylonas, Eoin D. O'Sullivan, Duncan Humphries, David P. Baird, Marie-Helena Docherty, Sarah A. Neely, Paul J. Krimpenfort, Anette Melk, Roland Schmitt, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Jeremy Hughes, David A. Ferenbach
Summary: This study demonstrated the impact of senescent cells on functional loss in human aging, chronic kidney disease, and radiation nephropathy, as well as the causative role of senescence in enhanced fibrosis in aged and irradiated murine kidneys after injury. Treatments targeting senescent cells, such as the B cell lymphoma 2/w/xL inhibitor ABT-263, were shown to reduce senescent cell numbers and restore regenerative capacity in kidneys, leading to improved function and reduced fibrosis after injury, suggesting a potential therapeutic option for protecting aging and vulnerable kidneys.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Eoin D. O'Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David P. Baird, Carolynn Cairns, Kevin M. Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C. Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A. Ferenbach
Summary: Progressive fibrosis and maladaptive organ repair lead to significant morbidity and premature deaths. Senescent cells play a role in organ fibrosis, but the mechanisms behind the influence of senescence on repair are poorly understood. This study demonstrated that senescent epithelial cells persist after injury, promoting ongoing fibrosis and impeding adaptive repair. Depletion of senescent cells reduced fibrosis in mouse models and in human kidney disease. The profibrotic protein PDIA3 was identified as a potential therapeutic target for reducing kidney fibrosis.
Article
Biochemistry & Molecular Biology
Xiaozhong Zheng, Ailiang Zhang, Margaret Binnie, Kris McGuire, Scott P. Webster, Jeremy Hughes, Sarah E. M. Howie, Damian J. Mole
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Article
Health Care Sciences & Services
David Paul Baird, Fraser Rae, Christina Beecroft, Katherine Gallagher, Stephanie Sim, Robert Vaessen, Emily Wright, Samira Bell