Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)

Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

(2021) Yelixza I. Avila et al.   MOLECULES

Nucleic acid nanoparticles (NANPs) as molecular tools to direct desirable and avoid undesirable immunological effects

(2021) M. Brittany Johnson et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

(2020) Gaofeng Liang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

(2020) Taejin Kim et al.   Molecular Therapy-Nucleic Acids

An emerging focus on lipids in extracellular vesicles

(2020) Tore Skotland et al.   ADVANCED DRUG DELIVERY REVIEWS

Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells

(2020) M. Brittany Johnson et al.   Journal of Neuroinflammation

Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties

(2020) Morgan Chandler et al.   Nanomedicine

Combination of Nucleic Acid and Mesoporous Silica Nanoparticles: Optimization and Therapeutic Performance In Vitro

(2020) Ridhima Juneja et al.   ACS Applied Materials & Interfaces

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

(2020) Kirill A. Afonin et al.   ACS Nano

Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

(2020) Marina A. Dobrovolskaia et al.   Nature Protocols

The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification

(2020) Morgan Brittany Johnson et al.   NUCLEIC ACIDS RESEARCH

Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

(2020) Feili Yan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

(2020) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

The emerging role of exosomes in mental disorders

(2019) Saumeh Saeedi et al.   Translational Psychiatry

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Clinical advances of siRNA therapeutics

(2019) Bo Hu et al.   JOURNAL OF GENE MEDICINE

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

(2019) Guo-hong Cui et al.   Immunity & Ageing

Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior

(2019) Chandler et al.   Nanomaterials

Transgenic Exosomes for Thymus Regeneration

(2019) Krisztina Banfai et al.   Frontiers in Immunology

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

Nucleic Acid Nanoparticles at a Crossroads of Vaccines and Immunotherapies

(2019) Marina A. Dobrovolskaia   MOLECULES

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Development and MPI tracking of novel hypoxia-targeted theranostic exosomes

(2018) Kyung Oh Jung et al.   BIOMATERIALS

Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

(2018) Bin Zhang et al.   CYTOTHERAPY

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

(2018) Golam Kibria et al.   MOLECULAR PHARMACEUTICS

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

(2018) Maria Yu. Konoshenko et al.   Biomed Research International

Therapeutic Potential of Mesenchymal Cell–Derived miRNA-150-5p–Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF

(2018) Zhe Chen et al.   JOURNAL OF IMMUNOLOGY

Extracellular Vesicles Work as a Functional Inflammatory Mediator Between Vascular Endothelial Cells and Immune Cells

(2018) Baharak Hosseinkhani et al.   Frontiers in Immunology

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers

(2018) Chandan Kanta Das et al.   MOLECULAR PHARMACEUTICS

Broccoli Fluorets: Split Aptamers as a User-Friendly Fluorescent Toolkit for Dynamic RNA Nanotechnology

(2018) Morgan Chandler et al.   MOLECULES

RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

(2018) Weina Ke et al.   NUCLEIC ACIDS RESEARCH

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

(2017) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Review of toxicity studies of carbon nanotubes

(2017) Norihiro Kobayashi et al.   JOURNAL OF OCCUPATIONAL HEALTH

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

Different Potential of Extracellular Vesicles to Support Thrombin Generation: Contributions of Phosphatidylserine, Tissue Factor, and Cellular Origin

(2017) Carla Tripisciano et al.   Scientific Reports

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

(2017) Yuan Wan et al.   Nature Biomedical Engineering

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

(2016) Masaki Morishita et al.   BIOMATERIALS

Therapeutic nucleic acids: current clinical status

(2016) Kannan Sridharan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches

(2016) Eckart Bindewald et al.   NANO LETTERS

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

(2015) Yueting Wu et al.   ANALYST

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

(2015) Natasa Zarovni et al.   METHODS

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

(2015) Douglas D. Taylor et al.   METHODS

In vivo toxicity of cationic micelles and liposomes

(2015) Kristina Bram Knudsen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

(2015) Amy Chan et al.   Molecular Therapy-Nucleic Acids

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

(2015) Tamás Baranyai et al.   PLoS One

An Aptamer–siRNA Chimera Silences the Eukaryotic Elongation Factor 2 Gene and Induces Apoptosis in Cancers Expressing αvβ3 Integrin

(2015) Ahmad Fawzi Hussain et al.   Nucleic Acid Therapeutics

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Lomitapide and Mipomersen

(2014) Daniel J. Rader et al.   CIRCULATION

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

(2014) Mei He et al.   LAB ON A CHIP

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Ceramide: A simple sphingolipid with unique biophysical properties

(2014) Bruno M. Castro et al.   PROGRESS IN LIPID RESEARCH

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

(2013) F.T. Borges et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Mutation of SIMPLE in Charcot–Marie–Tooth 1C alters production of exosomes

(2013) Hong Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of different split functionalities on re-association of RNA–DNA hybrids

(2013) Kirill A. Afonin et al.   Nature Nanotechnology

Co-transcriptional production of RNA–DNA hybrids for simultaneous release of multiple split functionalities

(2013) Kirill A. Afonin et al.   NUCLEIC ACIDS RESEARCH

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing

(2013) Piroon Jenjaroenpun et al.   PeerJ

Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

(2012) Daniela Zech et al.   Cell Communication and Signaling

Immature Dendritic Cell-Derived Exosomes: a Promise Subcellular Vaccine for Autoimmunity

(2012) Weifan Yin et al.   INFLAMMATION

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

(2012) Qi Zhou et al.   International Journal of Biological Sciences

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

SHAPE-directed Discovery of Potent shRNA Inhibitors of HIV-1

(2012) Justin T Low et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Cell-derived vesicles exposing coagulant tissue factor in saliva

(2011) R. J. Berckmans et al.   BLOOD

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

(2011) Kévin Carayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine

(2011) Kirill A Afonin et al.   Nature Protocols

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Application of Phi29 Motor pRNA for Targeted Therapeutic Delivery of siRNA Silencing Metallothionein-IIA and Survivin in Ovarian Cancers

(2010) Pheruza Tarapore et al.   MOLECULAR THERAPY

Milk fat globule—epidermal growth factor—factor VIII (MFGE8)/lactadherin promotes bladder tumor development

(2010) G Sugano et al.   ONCOGENE

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery

(2010) Juan L. Vivero-Escoto et al.   Small

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Membrane Protein Targeting to the MVB/Lysosome

(2009) Brian A. Davies et al.   CHEMICAL REVIEWS

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

(2009) Janos Szebeni et al.   JOURNAL OF LIPOSOME RESEARCH

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

(2008) D. L. Sprague et al.   BLOOD

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD