Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

(2020) Kirill A. Afonin et al.   ACS Nano

RNA nanotechnology in synthetic biology

(2020) Jongmin Kim et al.   CURRENT OPINION IN BIOTECHNOLOGY

Functional crosstalk between T cells and monocytes in cancer and atherosclerosis

(2020) Lindsey E. Padgett et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors

(2020) Marina A. Dobrovolskaia et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

(2020) Marina A. Dobrovolskaia et al.   Nature Protocols

The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification

(2020) Morgan Brittany Johnson et al.   NUCLEIC ACIDS RESEARCH

The applications of functionalized DNA nanostructures in bioimaging and cancer therapy

(2020) Yun Zeng et al.   BIOMATERIALS

Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: The role of oxidative stress

(2020) Sisi Feng et al.   TOXICOLOGY IN VITRO

Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells

(2020) Xuting Liu et al.   JOURNAL OF HAZARDOUS MATERIALS

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Autonomous dynamic control of DNA nanostructure self-assembly

(2019) Leopold N. Green et al.   Nature Chemistry

Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior

(2019) Chandler et al.   Nanomaterials

Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16

(2019) Michelle Ma et al.   JOURNAL OF IMMUNOLOGY

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

Nucleic Acid Nanoparticles at a Crossroads of Vaccines and Immunotherapies

(2019) Marina A. Dobrovolskaia   MOLECULES

A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (Nanps) for controlled gene silencing, immunostimulation, and biodistribution

(2019) Justin R. Halman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Pixel Counting of Fluorescence Spots Triggered by DNA Walkers for Ultrasensitive Quantification of Nucleic Acid

(2018) Longyi Zhu et al.   ANALYTICAL CHEMISTRY

Dynamic Behavior of RNA Nanoparticles Analyzed by AFM on a Mica/Air Interface

(2018) Sameer Sajja et al.   LANGMUIR

Computer Simulation of DNA Condensation by PAMAM Dendrimer

(2018) Yunxiang Su et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

(2018) Weina Ke et al.   NUCLEIC ACIDS RESEARCH

Functionally-interdependent shape-switching nanoparticles with controllable properties

(2017) Justin R. Halman et al.   NUCLEIC ACIDS RESEARCH

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

(2016) Yang Du et al.   ADVANCED MATERIALS

Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions

(2016) Christine Grimaldi et al.   CYTOKINE

Improvement of Cellular Uptake and Transfection Ability of pDNA Using α-Cyclodextrin-Polyamidoamine Conjugates as Gene Delivery System

(2016) Linghao Qin et al.   Journal of Biomedical Nanotechnology

Second Generation Amphiphilic Poly-Lysine Dendrons Inhibit Glioblastoma Cell Proliferation without Toxicity for Neurons or Astrocytes

(2016) Jolanta Janiszewska et al.   PLoS One

Designer nanoscale DNA assemblies programmed from the top down

(2016) R. Veneziano et al.   SCIENCE

Current understanding of interactions between nanoparticles and the immune system

(2016) Marina A. Dobrovolskaia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Partially PEGylated dendrimer-entrapped gold nanoparticles: a promising nanoplatform for highly efficient DNA and siRNA delivery

(2016) Wenxiu Hou et al.   Journal of Materials Chemistry B

A novel ultrasensitive electrochemical DNA sensor based on double tetrahedral nanostructures

(2015) Dongdong Zeng et al.   BIOSENSORS & BIOELECTRONICS

Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by SRL peptide for targeted gene delivery to the brain

(2015) Amir Zarebkohan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Induction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA

(2015) Anna N. Ilinskaya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of phosphoinositol 3 kinase contributes to nanoparticle-mediated exaggeration of endotoxin-induced leukocyte procoagulant activity

(2013) Anna N Ilinskaya et al.   Nanomedicine

Cytokine Profile in a Cohort of Healthy Blood Donors Carrying Polymorphisms in Genes Encoding the NLRP3 Inflammasome

(2013) Berolla Sahdo et al.   PLoS One

Dendrimer-entrapped gold nanoparticles modified with folic acid for targeted gene delivery applications

(2013) Tongyu Xiao et al.   Biomaterials Science

Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application

(2012) Silke C Mueller et al.   BMC Medical Research Methodology

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Intra-individual variability over time in serum cytokine levels among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

(2011) Jonathan N. Hofmann et al.   CYTOKINE

Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro

(2011) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface charge

(2011) Marina A Dobrovolskaia et al.   Nanomedicine

Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency

(2011) HUI WANG et al.   Experimental and Therapeutic Medicine

In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers

(2010) Paula Ofek et al.   FASEB JOURNAL

Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

(2009) Thommey P. Thomas et al.   BIOMACROMOLECULES

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

(2008) Pascale R. Leroueil et al.   NANO LETTERS