Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex

DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes

(2021) Maria Lytrivi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

(2021) Sarah O'Keefe et al.   JOURNAL OF CELL SCIENCE

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

(2021) Samuel Itskanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SEC62 and SEC63 Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue

(2021) Markus Casper et al.   Visceral Medicine

INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH

(2021) Denisa Hathazi et al.   BRAIN

TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61-channel

(2020) Marie-Christine Klein et al.   Channels

Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import

(2020) Stefan Schorr et al.   FEBS Journal

A clearer picture of the ER translocon complex

(2020) Max Gemmer et al.   JOURNAL OF CELL SCIENCE

Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia

(2020) Erika Van Nieuwenhove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

The architecture of EMC reveals a path for membrane protein insertion

(2020) John P O'Donnell et al.   eLife

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

(2020) Dale Tranter et al.   ACS Chemical Biology

ERdj8 governs the size of autophagosomes during the formation process

(2020) Yo-hei Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Structure of the Inhibited State of the Sec Translocon

(2020) Samuel F. Gérard et al.   MOLECULAR CELL

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

Novel insights into diabetes mellitus due to DNAJC3 ‐ defect:Evolution of neurological and endocrine phenotype in the pediatric age group

(2020) Z. Alev Ozon et al.   PEDIATRIC DIABETES

An intramembrane chaperone complex facilitates membrane protein biogenesis

(2020) Patrick J. Chitwood et al.   NATURE

An ER translocon for multi-pass membrane protein biogenesis

(2020) Philip T McGilvray et al.   eLife

A Recurrent Pathogenic Variant of INPP5K Underlies Autosomal Recessive Congenital Muscular Dystrophy With Cataracts and Intellectual Disability: Evidence for a Founder Effect in Southern Italy

(2020) Adele D’Amico et al.   Frontiers in Genetics

Architecture of the active post‐translational Sec translocon

(2020) Tsai‐Hsuan Weng et al.   EMBO JOURNAL

Defective lysosome reformation during autophagy causes skeletal muscle disease

(2020) Meagan J. McGrath et al.   JOURNAL OF CLINICAL INVESTIGATION

A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

(2020) Hao-Hsuan Hsieh et al.   Nature Communications

Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study

(2019) Ferenc Zoltan Takacs et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Store-operated calcium entry in disease: Beyond STIM/Orai expression levels

(2019) Sven Kappel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

(2019) Anke Ziska et al.   Biology Open

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer

(2019) Ferenc Zoltan Takacs et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Mutant MATR3 mouse model to explain multisystem proteinopathy

(2019) Xiao Zhang et al.   JOURNAL OF PATHOLOGY

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

(2019) Guanghui Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma

(2019) Bo Liu et al.   MEDICAL SCIENCE MONITOR

ER import of small human presecretory proteins: components and mechanisms

(2019) Sarah Haßdenteufel et al.   FEBS LETTERS

The Ways of Tails: the GET Pathway and more

(2019) Nica Borgese et al.   PROTEIN JOURNAL

Identification of Cellular Pathogenicity Markers for SIL1 Mutations Linked to Marinesco-Sjögren Syndrome

(2019) Christian Gatz et al.   Frontiers in Neurology

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

(2019) Jing Yong et al.   eLife

Autosomal dominant tubulointerstitial kidney disease

(2019) Olivier Devuyst et al.   Nature Reviews Disease Primers

Etiology-Specific Analysis of Hepatocellular Carcinoma Transcriptome Reveals Genetic Dysregulation in Pathways Implicated in Immunotherapy Efficacy

(2019) Wei Tse Li et al.   Cancers

UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor

(2019) Megan C. Kopp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling

(2019) Juan Du et al.   Oncogenesis

Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)

(2018) Desirée Schubert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane

(2018) Yasunori Yamamoto et al.   Scientific Reports

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

(2018) Sarah Haßdenteufel et al.   Cell Reports

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

The inositol 5-phosphatase INPP5K participates in the fine control of ER organization

(2018) Rui Dong et al.   JOURNAL OF CELL BIOLOGY

ER-phagy at a glance

(2018) Paolo Grumati et al.   JOURNAL OF CELL SCIENCE

Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors

(2018) Camille I. Pataki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum

(2018) Marie-Christine Klein et al.   Nature Communications

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

(2018) Duy Nguyen et al.   Nature Communications

Sec62/Ki67 dual staining in cervical cytology specimens: a new marker for high-grade dysplasia

(2018) Ferenc Zoltan Takacs et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

Function, evolution, and structure of J-domain proteins

(2018) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

Structure of the posttranslational Sec protein-translocation channel complex from yeast

(2018) Samuel Itskanov et al.   SCIENCE

Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features

(2018) Cornelia M�ller et al.   Oncology Letters

SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human

(2018) Vietxuan Phan et al.   NEUROBIOLOGY OF DISEASE

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

(2017) Joseph Casson et al.   JOURNAL OF CELL SCIENCE

Targeting and translocation of proteins to the endoplasmic reticulum at a glance

(2017) Naama Aviram et al.   JOURNAL OF CELL SCIENCE

Isolated polycystic liver disease genes define effectors of polycystin-1 function

(2017) Whitney Besse et al.   JOURNAL OF CLINICAL INVESTIGATION

Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level

(2017) Thomas Labisch et al.   MOLECULAR NEUROBIOLOGY

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YidC Insertase of Escherichia coli : Water Accessibility and Membrane Shaping

(2017) Yuanyuan Chen et al.   STRUCTURE

A Case for Sec61 Channel Involvement in ERAD

(2017) Karin Römisch   TRENDS IN BIOCHEMICAL SCIENCES

Dissecting the molecular organization of the translocon-associated protein complex

(2017) Stefan Pfeffer et al.   Nature Communications

In-depth phenotyping of lymphoblastoid cells suggests selective cellular vulnerability in Marinesco-Sjögren syndrome

(2017) Laxmikanth Kollipara et al.   Oncotarget

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases

(2017) Sven Lang et al.   Frontiers in Physiology

Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

(2016) Nikhita Ajit Bolar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions

(2016) Maximilian Linxweiler et al.   BMC CANCER

TMCO1 Is an ER Ca 2+ Load-Activated Ca 2+ Channel

(2016) Qiao-Chu Wang et al.   CELL

Glucose-regulated protein 78 (GRP78) binds directly to PIP3phosphatase SKIP and determines its localization

(2016) Takeshi Ijuin et al.   GENES TO CELLS

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Conserved Cysteine within the ATPase Domain of the Endoplasmic Reticulum Chaperone BiP is Necessary for a Complete Complement of BiP Activities

(2016) Mengni Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies

(2016) Laxmikanth Kollipara et al.   JOURNAL OF PROTEOME RESEARCH

Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix

(2016) Qiuyue Chen et al.   MOLECULAR CELL

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains

(2016) Bianca Schrul et al.   NATURE CELL BIOLOGY

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis

(2016) Claire S. Leblond et al.   NEUROBIOLOGY OF AGING

Visualizing the molecular sociology at the HeLa cell nuclear periphery

(2016) J. Mahamid et al.   SCIENCE

Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma

(2016) SILKE WEMMERT et al.   Oncology Letters

Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas

(2016) Florian Bochen et al.   Oncotarget

Form Follows Function: The Importance of Endoplasmic Reticulum Shape

(2015) L.M. Westrate et al.   Annual Review of Biochemistry

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Expanding the Molecular and Clinical Phenotype of SSR4-CDG

(2015) Bobby G. Ng et al.   HUMAN MUTATION

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells

(2015) Matthias Zehner et al.   IMMUNITY

Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum

(2015) Stefan Schorr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Transport into the Human Endoplasmic Reticulum

(2015) Johanna Dudek et al.   JOURNAL OF MOLECULAR BIOLOGY

BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions

(2015) Julia Behnke et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

(2015) Zan-Chao Liu et al.   MOLECULAR NEUROBIOLOGY

Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery

(2015) Andreas Roos et al.   MOLECULAR NEUROBIOLOGY

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

(2015) Audrey Filézac de L'Etang et al.   NATURE NEUROSCIENCE

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

(2015) Anastasia Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration

(2014) Matthis Synofzik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Protein transport into the human ER and related diseases, Sec61-channelopathies

(2014) Sarah Haßdenteufel et al.   Biochemistry and Cell Biology

Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells

(2014) Ahmed M. Osman et al.   BIOCHIMIE

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

(2014) Huan Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins

(2014) S.-j. Jung et al.   JOURNAL OF CELL SCIENCE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

Myopathy in Marinesco–Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

(2013) Andreas Roos et al.   ACTA NEUROPATHOLOGICA

TRAP assists membrane protein topogenesis at the mammalian ER membrane

(2013) Nicole Sommer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

(2013) Maximilian Linxweiler et al.   BMC CANCER

SIL1 mutations and clinical spectrum in patients with Marinesco-Sjögren syndrome

(2013) Michael Krieger et al.   BRAIN

Interaction ofPseudomonas aeruginosaExotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum

(2013) Nico Schäuble et al.   Channels

A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex

(2013) M. E. Losfeld et al.   HUMAN MOLECULAR GENETICS

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

(2013) Johannes H. Reithinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects

(2013) Jill M. Fritz et al.   MOLECULAR BIOLOGY OF THE CELL

ATP increases within the lumen of the endoplasmic reticulum upon intracellular Ca2+ release

(2013) Neelanjan Vishnu et al.   MOLECULAR BIOLOGY OF THE CELL

ERdj5 Is the ER Reductase that Catalyzes the Removal of Non-Native Disulfides and Correct Folding of the LDL Receptor

(2013) Ojore Benedict Valentine Oka et al.   MOLECULAR CELL

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

(2013) Markus Casper et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

(2013) A. R. English et al.   Cold Spring Harbor Perspectives in Biology

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

(2013) D. Hagerstrand et al.   Cancer Discovery

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

ERdj4 Protein Is a Soluble Endoplasmic Reticulum (ER) DnaJ Family Protein That Interacts with ER-associated Degradation Machinery

(2012) Chunwei Walter Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

(2012) Steven F. Trueman et al.   JOURNAL OF CELL BIOLOGY

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection

(2012) Li Weng et al.   Molecular Cancer

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences

(2012) Daniel Bakowski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes

(2012) Stefan Pfeffer et al.   STRUCTURE

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

(2012) D. Ron et al.   Cold Spring Harbor Perspectives in Biology

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Long-Timescale Dynamics and Regulation of Sec-Facilitated Protein Translocation

(2012) Bin Zhang et al.   Cell Reports

Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S71–467)

(2011) Neelagandan Kamariah et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Sec62 Bridges the Gap from 3q Amplification to Molecular Cell Biology in Non–Small Cell Lung Cancer

(2011) Maximilian Linxweiler et al.   AMERICAN JOURNAL OF PATHOLOGY

Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex

(2011) Prasanna K. Devaraneni et al.   CELL

Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates

(2011) Anke Harsman et al.   Channels

Sec61 complexes form ubiquitous ER Ca2+leak channels

(2011) Sven Lang et al.   Channels

Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer

(2011) Chung-Wei Fan et al.   CLINICA CHIMICA ACTA

WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane

(2011) F. Vilardi et al.   JOURNAL OF CELL SCIENCE

Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

(2011) Steven F. Trueman et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis of an ERAD Pathway Mediated by the ER-Resident Protein Disulfide Reductase ERdj5

(2011) Masatoshi Hagiwara et al.   MOLECULAR CELL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

(2011) Sorin V Fedeles et al.   NATURE GENETICS

The Crystal Structure of the Human Co-Chaperone P58IPK

(2011) Maria Svärd et al.   PLoS One

Sec62 protein level is crucial for the ER stress tolerance of prostate cancer

(2011) Markus Greiner et al.   PROSTATE

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The ER in 3D: a multifunctional dynamic membrane network

(2011) Jonathan R. Friedman et al.   TRENDS IN CELL BIOLOGY

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death

(2011) J. D. Malhotra et al.   Cold Spring Harbor Perspectives in Biology

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

(2011) Sven Lang et al.   Jove-Journal of Visualized Experiments

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Protein dislocation from the ER

(2010) Katrin Bagola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting pathways of C-tail-anchored proteins

(2010) Nica Borgese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanisms Determining the Morphology of the Peripheral ER

(2010) Yoko Shibata et al.   CELL

Intracellular Ca2+ storage in health and disease: A dynamic equilibrium

(2010) Eva Sammels et al.   CELL CALCIUM

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry

(2010) Jinn-Shiun Chen et al.   FEBS Journal

Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells

(2010) Markus Greiner et al.   INTERNATIONAL JOURNAL OF CANCER

BiP Modulates the Affinity of Its Co-chaperone ERj1 for Ribosomes

(2010) Julia Benedix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis

(2010) Kurt Dejgaard et al.   JOURNAL OF PROTEOME RESEARCH

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Remote Origins of Tail-Anchored Proteins

(2010) Nica Borgese et al.   TRAFFIC

Dominant Renin Gene Mutations Associated with Early-Onset Hyperuricemia, Anemia, and Chronic Kidney Failure

(2009) Martina Živná et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal-Dominant Distal Myopathy Associated with a Recurrent Missense Mutation in the Gene Encoding the Nuclear Matrix Protein, Matrin 3

(2009) Jan Senderek et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Glioblastoma Proto-oncogene SEC61  Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress

(2009) Z. Lu et al.   CANCER RESEARCH

A Point Mutation in Sec61 1 Leads to Diabetes and Hepatosteatosis in Mice

(2009) D. J. Lloyd et al.   DIABETES

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

(2009) Lihong Zhao et al.   HUMAN MOLECULAR GENETICS

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Intricate Links between ER Stress and Apoptosis

(2009) Frank Madeo et al.   MOLECULAR CELL

Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7

(2009) René P. Zahedi et al.   PROTEOMICS

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

How antibodies fold

(2009) Matthias J. Feige et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

ERdj3, a Luminal ER DnaJ Homologue, Binds Directly to Unfolded Proteins in the Mammalian ER: Identification of Critical Residues†

(2008) Yi Jin et al.   BIOCHEMISTRY

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Regulated release of ERdj3 from unfolded proteins by BiP

(2008) Yi Jin et al.   EMBO JOURNAL

Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer

(2008) Y Tsukamoto et al.   JOURNAL OF PATHOLOGY

Vacuolar Degeneration of Skeletal Muscle in Transgenic Mice Overexpressing ORP150

(2008) Tomohiro KOBAYASHI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Disrupted cell adhesion but not proliferation mediates cyst formation in polycystic liver disease

(2008) Esmé Waanders et al.   MODERN PATHOLOGY

ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C

(2008) Mei Dong et al.   MOLECULAR BIOLOGY OF THE CELL

BiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP

(2008) W. Awad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

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Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

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