A clearer picture of the ER translocon complex

Rapid Tilt-Series Acquisition for Electron Cryotomography

(2019) Georges Chreifi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins

(2019) Maarten W. Tuijtel et al.   Scientific Reports

Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation

(2018) Rebekka Wild et al.   SCIENCE

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

(2018) Katharina Braunger et al.   SCIENCE

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

The atomic structure of a eukaryotic oligosaccharyltransferase complex

(2018) Lin Bai et al.   NATURE

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

(2018) Duy Nguyen et al.   Nature Communications

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

emClarity: software for high-resolution cryo-electron tomography and subtomogram averaging

(2018) Benjamin A. Himes et al.   NATURE METHODS

Structure of the posttranslational Sec protein-translocation channel complex from yeast

(2018) Samuel Itskanov et al.   SCIENCE

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

(2018) Diego Acosta-Alvear et al.   eLife

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

(2017) Arati Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase

(2017) Maja Napiórkowska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Dissecting the molecular organization of the translocon-associated protein complex

(2017) Stefan Pfeffer et al.   Nature Communications

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome

(2017) Ahmad Jomaa et al.   Nature Communications

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase

(2017) Maja Napiórkowska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

The Sec61 translocon limits IRE1α signaling during the unfolded protein response

(2017) Arunkumar Sundaram et al.   eLife

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases

(2017) Sven Lang et al.   Frontiers in Physiology

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

(2016) Martin Beck et al.   TRENDS IN CELL BIOLOGY

YidC/Alb3/Oxa1 Family of Insertases

(2015) Seth W. Hennon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein degradation corrects for imbalanced subunit stoichiometry in OST complex assembly

(2015) Susanne Mueller et al.   MOLECULAR BIOLOGY OF THE CELL

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

The revolution will not be crystallized: a new method sweeps through structural biology

(2015) Ewen Callaway   NATURE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

A YidC-like Protein in the Archaeal Plasma Membrane

(2015) Marta T. Borowska et al.   STRUCTURE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

A functional link between the co-translational protein translocation pathway and the UPR

(2015) Rachel Plumb et al.   eLife

Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion

(2014) Koh Takeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins

(2014) S.-j. Jung et al.   JOURNAL OF CELL SCIENCE

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Structural basis of Sec-independent membrane protein insertion by YidC

(2014) Kaoru Kumazaki et al.   NATURE

Autofocused 3D Classification of Cryoelectron Subtomograms

(2014) Yuxiang Chen et al.   STRUCTURE

Structural Basis of Substrate Specificity of Human Oligosaccharyl Transferase Subunit N33/Tusc3 and Its Role in Regulating Protein N-Glycosylation

(2014) Elisabeth Mohorko et al.   STRUCTURE

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

TRAP assists membrane protein topogenesis at the mammalian ER membrane

(2013) Nicole Sommer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural biology in situ—the potential of subtomogram averaging

(2013) John AG Briggs   CURRENT OPINION IN STRUCTURAL BIOLOGY

A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex

(2013) M. E. Losfeld et al.   HUMAN MOLECULAR GENETICS

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

(2013) Johannes H. Reithinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation

(2013) S. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylated calnexin is a key component of the ribosome-translocon complex

(2012) Asvin KK Lakkaraju et al.   EMBO JOURNAL

Malectin Forms a Complex with Ribophorin I for Enhanced Association with Misfolded Glycoproteins

(2012) Sheng-Ying Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

(2012) Kuang Shen et al.   NATURE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

X-ray structure of a bacterial oligosaccharyltransferase

(2011) Christian Lizak et al.   NATURE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The Sec translocase

(2010) David J.F. du Plessis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

BiP Modulates the Affinity of Its Co-chaperone ERj1 for Ribosomes

(2010) Julia Benedix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

(2009) Antje Schäfer et al.   EMBO JOURNAL

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

(2008) Jean-François Ménétret et al.   STRUCTURE

Classification of cryo-electron sub-tomograms using constrained correlation

(2007) Friedrich Förster et al.   JOURNAL OF STRUCTURAL BIOLOGY