Article
Biochemistry & Molecular Biology
Luiz Eduardo Baggio Savio, Raissa Leite-Aguiar, Vinicius Santos Alves, Robson Coutinho-Silva, Angela T. S. Wyse
Summary: Purinergic signaling is a crucial cell communication pathway mediated by extracellular nucleotides and nucleosides. Activation of P2 receptors influences the redox balance of cells, while enzymes like E-NTPDase1/CD39 and ecto-5'-nucleotidase/CD73 play key roles in regulating this process.
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Plant Sciences
Qianqian Qin, Yujun Zhao, Jiajun Zhang, Li Chen, Weina Si, Haiyang Jiang
Summary: In this study, an HSF gene ZmHsf11 was cloned from maize and found to negatively regulate the expression of oxidative stress-related genes, increase ROS levels, and decrease proline content, thereby reducing plant tolerance to heat stress.
Article
Cell Biology
Hong Zhang, Weibin Gong, Si Wu, Sarah Perrett
Summary: Cellular redox homeostasis is maintained by the balance between generation and elimination of ROS. Hsp70 proteins play a crucial role in mitigating oxidative stress and are involved in various cellular signaling pathways. ROS can directly modify Hsp70 proteins and indirectly modulate their activity and expression through redox-related signaling pathways.
Article
Multidisciplinary Sciences
Cheng-Han Lee, Tzu-Cheng Su, Ming-Sheng Lee, Chien-Sheng Hsu, Rei-Cheng Yang, Jun-Kai Kao
Summary: Hyperoxia is significantly involved in the development of lung injury, such as bronchopulmonary dysplasia (BPD), in premature infants or newborns. This study explored the potential of heat shock protein 70 (Hsp70) to prevent hyperoxia-induced lung injury in neonatal rats. The results showed that Hsp70 reduced early apoptosis of alveolar cells and decreased macrophage infiltration in the lung.
Article
Biology
Mate Mackei, Gabor Matis, Andor Molnar, Csilla Sebok, Julia Voroshazi, Laszlo Pal, Karoly Dublecz, Ferenc Husveth, Zsuzsanna Neogrady
Summary: The liver was found to be the most susceptible to heat-provoked oxidative stress, with rapid activation of protective pathways and the involvement of sHSP-s leading to an over-compensation mechanism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renyi Wu, Shanyi Li, Rasika Hudlikar, Lujing Wang, Ahmad Shannar, Rebecca Peter, Pochung Jordan Chou, Hsiao-Chen Dina Kuo, Zhigang Liu, Ah-Ng Kong
Summary: Biological redox signaling plays a crucial role in diseases by affecting cellular redox balance and gene expression. It interacts with mitochondrial metabolism and epigenetics. Certain phytochemicals possess both antioxidant and epigenetic modifying abilities, making them potentially beneficial for human health.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Zheng, Xiwen Xu, Yadong Chen, Jing Wang, Tingting Zhang, E. Zechen, Songlin Chen, Yingjie Liu
Summary: The study conducted a systematic identification and functional analysis of HSP70s in turbot, revealing their essential roles in adapting to various environmental stresses. The research identified 16 HSP70 genes distributed on nine chromosomes in turbot and provided valuable insights into their evolution, classification, and functional diversity. Expression analysis showed significant up- or downregulation of HSP70 genes under different stress conditions, with three genes (hspa1a, hspa1b, and hspa5) responding to all induced stresses, indicating their involvement in anti-stress mechanisms. These findings contribute to understanding the biological function of HSP70s in turbot and the development of stress-resistant strains in aquaculture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Shuyu Jiao, Chunyan Bai, Chunyun Qi, Heyong Wu, Lanxin Hu, Feng Li, Kang Yang, Chuheng Zhao, Hongsheng Ouyang, Daxin Pang, Xiaochun Tang, Zicong Xie
Summary: Research on porcine HSPA6 gene reveals its sensitivity to heat stress and other stimuli, with heat shock elements and a conserved region identified in the promoter region through precise gene editing. Downregulation of pHSPA6 significantly impacts key members of the HSP family, indicating potential implications for gene regulation mechanisms and drug target selection.
Article
Agriculture, Dairy & Animal Science
Tori E. Rudolph, Crystal M. Roach, Lance H. Baumgard, Jason W. Ross, Aileen F. Keating, Josh T. Selsby
Summary: The study found that heat stress and Zearalenone exposure can induce oxidative stress in porcine skeletal muscle, with potentially different responses in muscle fiber types. However, the combination of heat stress and Zearalenone did not significantly increase oxidative stress levels compared to individual exposures.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agronomy
Qing Yang, Jinping Liu, Yizhong Yang, Yanhui Lu
Summary: This study investigated the molecular mechanism for thermotolerance in Propylaea quatuordecimpunctata. Transcriptome sequencing analysis revealed that differentially expressed genes in response to high temperature were mainly involved in oxidation-reduction process and metabolic pathways. The results provide insights into the resistance of P. quatuordecimpunctata to high temperature stress.
Review
Oncology
Wentao Zeng, Xiaohang Long, Pu-Ste Liu, Xin Xie
Summary: Oncogene-induced hyper-proliferation in cancer cells leads to different stresses, including DNA-replication stress, metabolic stress, and oxidative stress. The excessive accumulation of reactive oxygen species (ROS) plays a crucial role in tumor progression by influencing cell signaling pathways. Cancer cells also rely on oxidative stress and increased iron demands to affect ferroptosis sensitivity. Targeting redox homeostasis and ferroptosis has become a promising approach to overcome drug resistance in cancer treatment. This review summarizes the current understanding of the interplay between redox regulation, ferroptosis, and oncogenic signaling in cancer biology, and discusses strategies for targeting oxidative stress and ferroptosis in cancer treatment.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Stefania Fortunato, Cecilia Lasorella, Nunzio Dipierro, Federico Vita, Maria Concetta de Pinto
Summary: The increase in environmental temperature due to global warming has a critical impact on plant growth and productivity. Heat stress can cause damage to biochemical and physiological processes, but plants have defense mechanisms, such as the heat stress response (HSR), which involves a complex network of heat shock factors (HSFs) and heat shock proteins (HSPs). Reactive oxygen species (ROS) can act as signal molecules in HSR, depending on the balance between their production and scavenging. Antioxidants play a critical role in maintaining an optimal redox environment, but the HS-dependent ROS burst triggers redox-dependent signaling cascades in the cell.
Review
Biochemistry & Molecular Biology
Yuh-Cherng Chai, John J. Mieyal
Summary: This Special Issue aims to advance the understanding of the roles of the GSH/Grx system in cellular homeostasis and disease processes. GSH is the most abundant non-enzymatic antioxidant/nucleophilic molecule in cells. The S-glutathionylation of proteins, a reversible post-translational modification, can act as a regulatory switch in cell signaling and redox homeostasis.
Article
Food Science & Technology
Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He, Haihui Zhang
Summary: This study investigated the effect and potential mechanism of RDPEER, an antioxidant oligopeptide derived from watermelon seeds, on heat stress-induced liver injury and cell damage. The results showed that supplementation with RDPEER attenuated hepatocyte injury by increasing cell viability, reducing ROS production, improving antioxidant enzyme activity, and decreasing MDA content. RDPEER also inhibited HPA axis hyperactivity, transaminase activity, and inflammatory factor levels, while activating the endogenous antioxidant pathway and reducing inflammatory factor transcription and heat shock protein expression. Overall, RDPEER supplementation enhanced antioxidant capacity and alleviated liver damage caused by heat stress, suggesting its potential use in nutritional interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Jie Wang, Carolyn S. Sevier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biology
Kevin D. Siegenthaler, Kristeen A. Pareja, Jie Wang, Carolyn S. Sevier
Article
Biochemistry & Molecular Biology
John P. O'Donnell, Heather M. Marsh, Holger Sondermann, Carolyn S. Sevier
Review
Biochemistry & Molecular Biology
Lars Ellgaard, Carolyn S. Sevier, Neil J. Bulleid
TRENDS IN BIOCHEMICAL SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Carolyn S. Sevier
ANTIOXIDANTS & REDOX SIGNALING
(2012)
Article
Biochemistry & Molecular Biology
Elvira Vitu, Sunghwan Kim, Carolyn S. Sevier, Omer Lutzky, Nimrod Heldman, Moran Bentzur, Tamar Unger, Meital Yona, Chris A. Kaiser, Deborah Fass
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Editorial Material
Cell Biology
Carolyn S. Sevier
JOURNAL OF CELL BIOLOGY
(2010)
Article
Cell Biology
Sunghwan Kim, Dionisia P. Sideris, Carolyn S. Sevier, Chris A. Kaiser
JOURNAL OF CELL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Nimrod Heldman, Ohad Vonshak, Carolyn S. Sevier, Elvira Vitu, Tevie Mehlman, Deborah Fass
Article
Veterinary Sciences
J. P. Loftus, D. Cavatorta, J. J. Bushey, C. B. Levine, C. S. Sevier, J. J. Wakshlag
VETERINARY AND COMPARATIVE ONCOLOGY
(2016)
Article
Biology
Jie Wang, Kristeen A. Pareja, Chris A. Kaiser, Carolyn S. Sevier
Editorial Material
Chemistry, Medicinal
Kevin D. Siegenthaler, Carolyn S. Sevier
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Erin E. Nicklow, Carolyn S. Sevier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Cell Biology
Jennifer M. Roscoe, Carolyn S. Sevier
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)