The Ways of Tails: the GET Pathway and more

Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane

(2019) Marina Blenski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting

(2019) Un Seng Chio et al.   Cell Reports

Biogenesis of chloroplast outer envelope membrane proteins

(2019) Jonghak Kim et al.   PLANT CELL REPORTS

The natural history of Get3‐like chaperones

(2019) Ákos Farkas et al.   TRAFFIC

A trap mutant reveals the physiological client spectrum of TRC40

(2019) Javier Coy-Vergara et al.   JOURNAL OF CELL SCIENCE

GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis

(2018) Jiao Liang et al.   CELL BIOCHEMISTRY AND FUNCTION

Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting

(2018) Hyunju Cho et al.   EMBO JOURNAL

SRP, FtsY, DnaK and YidC Are Required for the Biogenesis of the E. coli Tail-Anchored Membrane Proteins DjlC and Flk

(2018) Markus Peschke et al.   JOURNAL OF MOLECULAR BIOLOGY

Discrimination between the endoplasmic reticulum and mitochondria by spontaneously inserting tail-anchored proteins

(2018) Bruna Figueiredo Costa et al.   TRAFFIC

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

(2018) Sarah Haßdenteufel et al.   Cell Reports

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

A structural perspective on tail-anchored protein biogenesis by the GET pathway

(2018) Agnieszka Mateja et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes

(2018) Bogdan A. Cichocki et al.   TRAFFIC

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells

(2017) Joseph L. Costello et al.   JOURNAL OF CELL SCIENCE

Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

(2017) Joseph Casson et al.   JOURNAL OF CELL SCIENCE

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins

(2017) Matthew L. Wohlever et al.   MOLECULAR CELL

Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35

(2017) Jee-Young Mock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of GET pathway orthologs inArabidopsis thalianacauses root hair growth defects and affects SNARE abundance

(2017) Shuping Xing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Yet another hump for CAML: support of cell survival independent of tail-anchored protein insertion

(2017) Jennifer C Shing et al.   Cell Death & Disease

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer

(2017) Benjamin E. Zalisko et al.   Cell Reports

The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane

(2017) Nicholas R Weir et al.   eLife

Tryptophan‐rich basic protein (WRB) mediates insertion of the tail‐anchored protein otoferlin and is required for hair cell exocytosis and hearing

(2016) Christian Vogl et al.   EMBO JOURNAL

Tail-anchored Protein Insertion in Mammals

(2016) Sara Francesca Colombo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes

(2016) Renu Srivastava et al.   PLANT PHYSIOLOGY

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice

(2016) Lisa K. Philp et al.   Scientific Reports

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

(2016) Meera Rao et al.   eLife

Structural and functional insights into the E3 ligase, RNF126

(2016) Ewelina M. Krysztofinska et al.   Scientific Reports

Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

(2016) Jhon Rivera-Monroy et al.   Scientific Reports

A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition

(2015) Hirofumi Tanaka et al.   FEBS Journal

Emery–Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane

(2015) Janine Pfaff et al.   JOURNAL OF CELL SCIENCE

The zebrafishpinball wizardgene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors

(2015) Shuh-Yow Lin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching

(2015) Yu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins

(2015) Judith Buentzel et al.   Scientific Reports

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Evolving models for peroxisome biogenesis

(2014) Ewald H Hettema et al.   CURRENT OPINION IN CELL BIOLOGY

Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity

(2014) S. Sojka et al.   DEVELOPMENT

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

(2014) Y.-C. Chen et al.   EMBO JOURNAL

BAG6 regulates the quality control of a polytopic ERAD substrate

(2014) A. Payapilly et al.   JOURNAL OF CELL SCIENCE

SGTA regulates the cytosolic quality control of hydrophobic substrates

(2014) L. Wunderley et al.   JOURNAL OF CELL SCIENCE

The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions

(2014) Wilhelm Voth et al.   MOLECULAR CELL

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

(2014) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4

(2014) Harry B Gristick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WRB and CAML Are Necessary and Sufficient to Mediate Tail-Anchored Protein Targeting to the ER Membrane

(2014) Fabio Vilardi et al.   PLoS One

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy

(2014) S. Sebti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

(2014) Michael E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain

(2014) Jee-Young Mock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobic handoff for direct delivery of peroxisome tail-anchored proteins

(2014) Yinxiao Chen et al.   Nature Communications

Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission

(2013) Nina Huber et al.   EMBO REPORTS

Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway

(2013) Yuichi Yagita et al.   JOURNAL OF CELL BIOLOGY

The Association of BAG6 with SGTA and Tail-Anchored Proteins

(2013) Pawel Leznicki et al.   PLoS One

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise timing of ATPase activation drives targeting of tail-anchored proteins

(2013) M. E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

(2013) V. Denic et al.   Cold Spring Harbor Perspectives in Biology

The complex process of GETting tail-anchored membrane proteins to the ER

(2012) Justin W Chartron et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins

(2012) K. S. Dimmer et al.   JOURNAL OF CELL SCIENCE

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked

(2012) K. Powis et al.   JOURNAL OF CELL SCIENCE

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes

(2012) Katrin Krumpe et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

A portrait of the GET pathway as a surprisingly complicated young man

(2012) Vladimir Denic   TRENDS IN BIOCHEMICAL SCIENCES

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

(2012) Raymond J Louie et al.   Genome Medicine

Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins

(2011) Christian Kohl et al.   BIOLOGICAL CHEMISTRY

Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue

(2011) Christian JM Suloway et al.   EMBO JOURNAL

Generation of mice with conditional null allele for GdX/Ubl4A

(2011) Yangmeng Wang et al.   GENESIS

WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane

(2011) F. Vilardi et al.   JOURNAL OF CELL SCIENCE

Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice

(2011) Elizabeth C. Bryda et al.   MAMMALIAN GENOME

Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis

(2011) Peter W. Bircham et al.   Molecular BioSystems

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

(2011) Fei Wang et al.   MOLECULAR CELL

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

Targeting pathways of C-tail-anchored proteins

(2010) Nica Borgese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Expression of the congenital heart disease 5/tryptophan rich basic protein homologue gene during heart development in Medaka fish, Oryzias latipes

(2010) Kenji Murata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Bat3 promotes the membrane integration of tail-anchored proteins

(2010) P. Leznicki et al.   JOURNAL OF CELL SCIENCE

Peroxisomal Membrane Proteins Insert into the Endoplasmic Reticulum

(2010) Adabella van der Zand et al.   MOLECULAR BIOLOGY OF THE CELL

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

(2010) S. K. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote Origins of Tail-Anchored Proteins

(2010) Nica Borgese et al.   TRAFFIC

Structural insight into the membrane insertion of tail-anchored proteins by Get3

(2009) Atsushi Yamagata et al.   GENES TO CELLS

The role of cytosolic proteins in the insertion of tail-anchored proteins into phospholipid bilayers

(2009) S. F. Colombo et al.   JOURNAL OF CELL SCIENCE

Two Modular Forms of the Mitochondrial Sorting and Assembly Machinery Are Involved in Biogenesis of α-Helical Outer Membrane Proteins

(2009) Nicolas Thornton et al.   JOURNAL OF MOLECULAR BIOLOGY

Tail-Anchored Proteins in Plants

(2009) Emanuela Pedrazzini   JOURNAL OF PLANT BIOLOGY

The structural basis of tail-anchored membrane protein recognition by Get3

(2009) Agnieszka Mateja et al.   NATURE

The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion

(2009) Junbin Hu et al.   PLoS One

Structural insights into tail-anchored protein binding and membrane insertion by Get3

(2009) Gunes Bozkurt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model for eukaryotic tail-anchored protein binding based on the structure of Get3

(2009) C. J. M. Suloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Subcellular Distribution of Tail-Anchored Proteins in Arabidopsis

(2009) Verena Kriechbaumer et al.   TRAFFIC

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Targeting of hFis1 to Peroxisomes Is Mediated by Pex19p

(2008) Hannah K. Delille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins

(2008) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components

(2008) C. Kemper et al.   JOURNAL OF CELL SCIENCE

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL