Protein transport into the human ER and related diseases, Sec61-channelopathies

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

Myopathy in Marinesco–Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

(2013) Andreas Roos et al.   ACTA NEUROPATHOLOGICA

TRAP assists membrane protein topogenesis at the mammalian ER membrane

(2013) Nicole Sommer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

(2013) Maximilian Linxweiler et al.   BMC CANCER

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex

(2013) M. E. Losfeld et al.   HUMAN MOLECULAR GENETICS

Structure of the SecY channel during initiation of protein translocation

(2013) Eunyong Park et al.   NATURE

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

(2013) Nicholas Johnson et al.   PLoS One

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

(2013) A. R. English et al.   Cold Spring Harbor Perspectives in Biology

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences

(2012) Daniel Bakowski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes

(2012) Stefan Pfeffer et al.   STRUCTURE

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

(2012) D. Ron et al.   Cold Spring Harbor Perspectives in Biology

The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast

(2012) G. Thibault et al.   Cold Spring Harbor Perspectives in Biology

Disulfide Bond Formation in the Mammalian Endoplasmic Reticulum

(2012) N. J. Bulleid   Cold Spring Harbor Perspectives in Biology

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

Structure of the SecY Complex Unlocked by a Preprotein Mimic

(2012) Dilem Hizlan et al.   Cell Reports

Sec62 Bridges the Gap from 3q Amplification to Molecular Cell Biology in Non–Small Cell Lung Cancer

(2011) Maximilian Linxweiler et al.   AMERICAN JOURNAL OF PATHOLOGY

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

Sec61 complexes form ubiquitous ER Ca2+leak channels

(2011) Sven Lang et al.   Channels

Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane

(2011) Sarah Haßdenteufel et al.   FEBS LETTERS

Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylation

(2011) Elisabeth Mohorko et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Preserving the membrane barrier for small molecules during bacterial protein translocation

(2011) Eunyong Park et al.   NATURE

X-ray structure of a bacterial oligosaccharyltransferase

(2011) Christian Lizak et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

(2011) Sorin V Fedeles et al.   NATURE GENETICS

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

(2011) Sven Lang et al.   Jove-Journal of Visualized Experiments

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

Protein dislocation from the ER

(2010) Katrin Bagola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting pathways of C-tail-anchored proteins

(2010) Nica Borgese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

BiP Modulates the Affinity of Its Co-chaperone ERj1 for Ribosomes

(2010) Julia Benedix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioblastoma Proto-oncogene SEC61  Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress

(2009) Z. Lu et al.   CANCER RESEARCH

A Point Mutation in Sec61 1 Leads to Diabetes and Hepatosteatosis in Mice

(2009) D. J. Lloyd et al.   DIABETES

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

(2009) Antje Schäfer et al.   EMBO JOURNAL

Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity

(2009) Frank Erdmann et al.   FEBS LETTERS

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

(2009) Lihong Zhao et al.   HUMAN MOLECULAR GENETICS

Biogenesis of tail-anchored proteins: the beginning for the end?

(2009) C. Rabu et al.   JOURNAL OF CELL SCIENCE

Intricate Links between ER Stress and Apoptosis

(2009) Frank Madeo et al.   MOLECULAR CELL

Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7

(2009) René P. Zahedi et al.   PROTEOMICS

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Regulation of the Protein-Conducting Channel by a Bound Ribosome

(2009) James Gumbart et al.   STRUCTURE

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

(2008) Jean-François Ménétret et al.   STRUCTURE