SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

(2017) Kayvan Zainabadi et al.   PLoS One

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis

(2016) Bruce E. Sands et al.   INFLAMMATORY BOWEL DISEASES

The Nutrient and Energy Sensor Sirt1 Regulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Altering the Production of the Prohormone Convertase 2 (PC2) Essential in the Maturation of Corticotropin-releasing Hormone (CRH) from Its Prohormone in Male Rats

(2016) Anika M. Toorie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

(2015) Ha-Neui Kim et al.   MOLECULAR ENDOCRINOLOGY

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

(2015) Irina Gurt et al.   PLoS One

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

(2014) Arun Baksi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Sirtuin1 Activator SRT3025 Down-Regulates Sclerostin and Rescues Ovariectomy-Induced Bone Loss and Biomechanical Deterioration in Female Mice

(2014) Hanna Artsi et al.   ENDOCRINOLOGY

Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

(2014) Srividhya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial

(2014) Marie Juul Ornstrup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

(2014) HUAN GONG et al.   Molecular Medicine Reports

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

(2013) Evi M. Mercken et al.   AGING CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Evaluation of Reference Genes and Normalization Strategy for Quantitative Real-Time PCR in Human Pancreatic Carcinoma

(2013) Beatrice Mohelnikova-Duchonova et al.   DISEASE MARKERS

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration

(2013) J. Graff et al.   JOURNAL OF NEUROSCIENCE

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

Normalization with genes encoding ribosomal proteins but not GAPDH provides an accurate quantification of gene expressions in neuronal differentiation of PC12 cells

(2010) Lihan Zhou et al.   BMC GENOMICS

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

(2009) D. E. Cohen et al.   GENES & DEVELOPMENT

Calorie Restriction and Bone Health in Young, Overweight Individuals

(2008) Leanne M. Redman   ARCHIVES OF INTERNAL MEDICINE

The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1

(2008) Ullas Kolthur-Seetharam et al.   BIOLOGY OF REPRODUCTION

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One

Life-Long Caloric Restriction Reveals Biphasic and Dimorphic Effects on Bone Metabolism in Rodents

(2007) Sawako Tatsumi et al.   ENDOCRINOLOGY