Journal
AGING-US
Volume 10, Issue 7, Pages 1586-1596Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101494
Keywords
resveratrol; postovulatory aging; oocyte; oxidative stress
Categories
Funding
- Research Team of Female Reproductive Health and Fertility Preservation [SZSM201612065]
- Project for Medical Discipline Advancement of Health and Family Planning Commission of Shenzhen Municipality [SZXJ2017003]
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After ovulation, metaphase II oocytes undergo a time-dependent deterioration in vivo or in vitro, which is referred to as postovulatory oocyte aging, a process during which a series of deleterious molecular and cellular changes occur. In this study, we found that short-term injection of resveratrol (3,5,4'-trihydroxystilbene) effectively ameliorated oxidative stress-induced damage in postovulatory oocyte aging of middle-aged mice in vivo. Resveratrol induced changes that delayed the aging-induced oocyte deterioration including the elevated expression of the anti-aging molecule Sirtuin 1 (SIRT1); it reduced intracellular reactive oxygen species (ROS) level, and improved mitochondria function. In addition, these beneficial changes may also help to prevent apoptosis. Taken together, our data suggest that resveratrol can effectively protect against postovulatory oocyte aging in vivo primarily by preventing ROS production.
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