Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

(2020) Yizhou Jiang et al.   Cells

Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress

(2019) Min Zhao et al.   MEDICAL SCIENCE MONITOR

Metformin protects PC12 cells and hippocampal neurons from H2 O 2 -induced oxidative damage through activation of AMPK pathway

(2019) Xia Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition

(2019) Hengyi Chen et al.   Clinical Respiratory Journal

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK

(2018) Shuai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms

(2018) Chinwendu Nwadike et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity

(2018) Bassam Janji et al.   Frontiers in Immunology

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

The Anthocyanins, Oenin and Callistephin, Protect RPE Cells Against Oxidative Stress

(2017) Sally M. Yacout et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

(2017) Chunjuan Song et al.   PLoS One

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

(2016) Kai Kaarniranta et al.   CELL BIOLOGY AND TOXICOLOGY

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling

(2016) Cheong-Meng Chong et al.   Redox Biology

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

(2016) Jianzhong Li et al.   Scientific Reports

Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells

(2015) Deok-Bae Park   Diabetes & Metabolism Journal

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration

(2014) Rajendra N. Mitra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Geographic Atrophy

(2014) Frank G. Holz et al.   OPHTHALMOLOGY

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma

(2013) Qishan Tang et al.   CANCER LETTERS

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Why is autophagy important in human diseases?

(2012) Kaipeng Jing et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Effects of Metformin in Experimental Stroke

(2010) Jun Li et al.   STROKE

Using LC3 to monitor autophagy flux in the retinal pigment epithelium

(2009) Ai Ling Wang et al.   Autophagy