Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation

(2019) Lee S. Nguyen et al.   DRUG SAFETY

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

(2018) Candice E. Van Skike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction

(2018) Ashley Azar et al.   Annals of the New York Academy of Sciences

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

(2018) Ellen Kraig et al.   EXPERIMENTAL GERONTOLOGY

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Human and Microbial Proteins From Corpora Amylacea of Alzheimer’s Disease

(2018) Diana Pisa et al.   Scientific Reports

Topical Sirolimus to Treat Tuberous Sclerosis Complex (TSC)

(2018) Thomas N. Darling   JAMA Dermatology

Aging, Cell Senescence, and Chronic Disease

(2018) Tamara Tchkonia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exploring the elusive composition of corpora amylacea of human brain

(2018) Elisabet Augé et al.   Scientific Reports

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

(2017) Silvan R. Urfer et al.   GeroScience

Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner

(2016) Timothy Nacarelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Randomized, Blinded Study to Validate the Merz Hand Grading Scale for Use in Live Assessments

(2015) Joel L. Cohen et al.   DERMATOLOGIC SURGERY

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

(2015) Timothy Nacarelli et al.   EXPERIMENTAL GERONTOLOGY

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

(2015) Mariëtte E. C. Waaijer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

(2015) S. Vigili de Kreutzenberg et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Type VII Collagen Expression in the Human Vitreoretinal Interface, Corpora Amylacea and Inner Retinal Layers

(2015) Bart Wullink et al.   PLoS One

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

(2014) Kenneth Maiese   ANNALS OF MEDICINE

Forehead wrinkles: a histological and immunohistochemical evaluation

(2014) Moetaz El-Domyati et al.   Journal of Cosmetic Dermatology

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Aging in elderly: Chronological versus photoaging

(2012) DevinderMohan Thappa et al.   INDIAN JOURNAL OF DERMATOLOGY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

(2010) Alessandro Bitto et al.   PLoS One

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE