Cryo-EM structure of human mTOR complex 2

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

(2017) Manikandan Karuppasamy et al.   Nature Communications

Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

(2017) Hisashi Tatebe et al.   eLife

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tor forms a dimer through an N-terminal helical solenoid with a complex topology

(2016) Domagoj Baretić et al.   Nature Communications

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

(2016) Huirong Yang et al.   Protein & Cell

Defining the Domain Arrangement of the Mammalian Target of Rapamycin Complex Component Rictor Protein

(2015) Ping Zhou et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

xiNET: Cross-link Network Maps With Residue Resolution

(2015) Colin W. Combe et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

PIKKs — the solenoid nest where partners and kinases meet

(2014) Domagoj Baretić et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints

(2014) Kyoko Furuita et al.   JOURNAL OF BIOMOLECULAR NMR

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

mTORC2 targets AGC kinases through Sin1-dependent recruitment

(2011) Angus J. M. Cameron et al.   BIOCHEMICAL JOURNAL

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

(2010) C A Sparks et al.   ONCOGENE

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL