17β-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model

Are Proteinopathy and Oxidative Stress Two Sides of the Same Coin?

(2019) Nihar Mehta et al.   Cells

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

(2019) Xinfang An et al.   Cells

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

(2019) Tahir Muhammad et al.   Nutrients

Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

(2019) Muhammad Ikram et al.   MOLECULAR NEUROBIOLOGY

MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells

(2019) Mehtab Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling

(2019) Muhammad Ikram et al.   Nutrients

Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration

(2019) Ullah et al.   Nutrients

Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro

(2019) Amjad Khan et al.   Journal of Clinical Medicine

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes

(2019) Shaimaa Mahmoud et al.   Cells

Involvement of Estrogen and Its Receptors in Morphological Changes in the Eyes of the Japanese Eel, Anguilla japonica, in the Process of Artificially-Induced Maturation

(2019) Ji-Yeon Hyeon et al.   Cells

pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo

(2019) Lu Zhao et al.   Cells

Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure

(2019) Bin Xu et al.   Cells

Estrogen deficiency exacerbates Aβ-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-ĸB activation in ovariectomized mice

(2018) Jaesuk Yun et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

(2018) Tahir Muhammad et al.   Journal of Neuroimmune Pharmacology

Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model—a Proteomic and in silico Approach

(2018) Fawad Ali Shah et al.   Frontiers in Neuroscience

miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs)

(2018) Adele Vivacqua et al.   Cells

A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1

(2018) Seon Song et al.   Cells

Mesenchymal Stem Cells (MSCs) Coculture Protects [Ca2+]i Orchestrated Oxidant Mediated Damage in Differentiated Neurons In Vitro

(2018) Adel Alhazzani et al.   Cells

17β-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication

(2017) Mehtab Khan et al.   MOLECULAR NEUROBIOLOGY

Pretreatment with 17β-Estradiol Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption in Aged Rats: Involvement of Antioxidant Signaling

(2017) Han Xiao et al.   NEUROENDOCRINOLOGY

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain

(2016) Shahid Ali Shah et al.   Journal of Neuroinflammation

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Menopause accelerates biological aging

(2016) Morgan E. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saponins fromPanax japonicusattenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats

(2015) Ting Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons

(2014) Qinru Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway

(2014) Zuo-hui Zhang et al.   BRAIN RESEARCH

The neuroprotective actions of oestradiol and oestrogen receptors

(2014) Maria-Angeles Arevalo et al.   NATURE REVIEWS NEUROSCIENCE

Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain

(2014) S A Shah et al.   Cell Death & Disease

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Do we age because we have mitochondria?

(2013) Jürgen Bereiter-Hahn   PROTOPLASMA

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1

(2013) Limin Han et al.   Protein & Cell

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism

(2012) Guang Zhe Huang et al.   NEURON

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

(2011) Ramkumar Rajendran et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Perimenopause and Cognition

(2011) Gail A. Greendale et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF- B Pathway Activation

(2010) J. Lu et al.   CEREBRAL CORTEX

Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors α and β

(2010) Candice M. Brown et al.   ENDOCRINOLOGY

Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling

(2009) Y. Yao et al.   CARCINOGENESIS

Effect of LTA isolated from bifidobacteria on d-galactose-induced aging

(2009) Zheng-Jun Yi et al.   EXPERIMENTAL GERONTOLOGY

Membrane estradiol signaling in the brain

(2009) Paul Micevych et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide

(2009) Diego Albani et al.   JOURNAL OF NEUROCHEMISTRY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Impairments of astrocytes are involved in the d-galactose-induced brain aging

(2008) Ming Lei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High glucose downregulates endothelial progenitor cell number via SIRT1

(2008) Maria Luisa Balestrieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL