Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

Structural basis for a complex I mutation that blocks pathological ROS production

(2021) Zhan Yin et al.   Nature Communications

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism

(2020) Atsuhito Tsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

(2020) David A. Russell et al.   JOURNAL OF NATURAL PRODUCTS

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration

(2020) Olivier Biner et al.   ACS Synthetic Biology

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

(2020) Zoe A Stephenson et al.   eLife

Respiratory complex I — structure, mechanism and evolution

(2020) Kristian Parey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation

(2020) Daniel N. Grba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The coupling mechanism of mammalian respiratory complex I

(2020) Domen Kampjut et al.   SCIENCE

Key role of quinone in the mechanism of respiratory complex I

(2020) Javier Gutiérrez-Fernández et al.   Nature Communications

Structure of inhibitor-bound mammalian complex I

(2020) Hannah R. Bridges et al.   Nature Communications

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

(2019) Sven Christian et al.   LEUKEMIA

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

(2019) Outi Haapanen et al.   Frontiers in Chemistry

Balanced internal hydration discriminates substrate binding to respiratory complex I

(2019) Murilo Hoias Teixeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I

(2019) Nikhil Madhusudhan et al.   ACS Chemical Biology

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

(2019) Kristian Parey et al.   Science Advances

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I

(2018) Ville R. I. Kaila   Journal of the Royal Society Interface

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten -Null Cells

(2018) Adam Naguib et al.   Cell Reports

Redox-coupled quinone dynamics in the respiratory complex I

(2018) Judith Warnau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches

(2018) Shinpei Uno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

(2018) Alfredo Cabrera-Orefice et al.   Nature Communications

Respiratory Complex I inBos taurusandParacoccus denitrificansPumps Four Protons across the Membrane for Every NADH Oxidized

(2017) Andrew J. Y. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I

(2017) Justin G. Fedor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Current topics on inhibitors of respiratory complex I

(2016) Masatoshi Murai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Enzyme Tunnels and Gates As Relevant Targets in Drug Design

(2016) Sergio M. Marques et al.   MEDICINAL RESEARCH REVIEWS

Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics

(2015) Ekramy Elmorsy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

(2015) Febin Varghese et al.   HUMAN MOLECULAR GENETICS

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

(2015) Naoki Imaizumi et al.   Redox Biology

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

The origins of enzyme kinetics

(2013) Athel Cornish-Bowden   FEBS LETTERS

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

(2013) Peter Ellinghaus et al.   Cancer Medicine

Tracing the tail of ubiquinone in mitochondrial complex I

(2012) Heike Angerer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Evolution of Respiratory Complex I

(2010) Chui-ying Yip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1 

(2008) S. H. Li et al.   MOLECULAR CANCER THERAPEUTICS

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

(2008) X. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA