Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Proton motive function of the terminal antiporter-like subunit in respiratory complex I

(2020) Amina Djurabekova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory complex I — structure, mechanism and evolution

(2020) Kristian Parey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of the complex I-like molecule NDH of oxygenic photosynthesis

(2019) Thomas G. Laughlin et al.   NATURE

Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I

(2019) Atsushi Banba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Balanced internal hydration discriminates substrate binding to respiratory complex I

(2019) Murilo Hoias Teixeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics

(2019) Etienne Galemou Yoga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk

(2019) James A. Letts et al.   MOLECULAR CELL

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

(2019) Kristian Parey et al.   Science Advances

How inter-subunit contacts in the membrane domain of complex I affect proton transfer energetics

(2018) Andrea Di Luca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Global collective motions in the mammalian and bacterial respiratory complex I

(2018) Andrea Di Luca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I

(2018) Ville R. I. Kaila   Journal of the Royal Society Interface

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

Structure of the Deactive State of Mammalian Respiratory Complex I

(2018) James N. Blaza et al.   STRUCTURE

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

Redox-coupled quinone dynamics in the respiratory complex I

(2018) Judith Warnau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations

(2018) Karol Fiedorczuk et al.   TRENDS IN CELL BIOLOGY

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

(2018) Alfredo Cabrera-Orefice et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cryo-EM structure of respiratory complex I at work

(2018) Kristian Parey et al.   eLife

Respiratory Complex I inBos taurusandParacoccus denitrificansPumps Four Protons across the Membrane for Every NADH Oxidized

(2017) Andrew J. Y. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I

(2017) Justin G. Fedor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Symmetry-related proton transfer pathways in respiratory complex I

(2017) Andrea Di Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Role of water and protein dynamics in proton pumping by respiratory complex I

(2017) Outi Haapanen et al.   Scientific Reports

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism

(2016) Edoardo D'Imprima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

The architecture of the mammalian respirasome

(2016) Jinke Gu et al.   NATURE

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

(2015) Febin Varghese et al.   HUMAN MOLECULAR GENETICS

MitoFates: Improved Prediction of Mitochondrial Targeting Sequences and Their Cleavage Sites

(2015) Yoshinori Fukasawa et al.   MOLECULAR & CELLULAR PROTEOMICS

Redox-induced activation of the proton pump in the respiratory complex I

(2015) Vivek Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Identification of local variations within secondary structures of proteins

(2015) Prasun Kumar et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterisation of the active/de-active transition of mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports

(2014) Joel R. Meyerson et al.   Scientific Reports

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Accessory subunits of mitochondrial complex I

(2013) Katarzyna Kmita et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Complex I deficiency: clinical features, biochemistry and molecular genetics

(2012) Elisa Fassone et al.   JOURNAL OF MEDICAL GENETICS

Analyses of the Large Subunit Histidine-Rich Motif Expose an Alternative Proton Transfer Pathway in [NiFe] Hydrogenases

(2012) Emma Szőri-Dorogházi et al.   PLoS One

A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I

(2011) Heike Angerer et al.   BIOCHEMICAL JOURNAL

A two-state stabilization-change mechanism for proton-pumping complex I

(2011) Ulrich Brandt   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of the membrane domain of respiratory complex I

(2011) Rouslan G. Efremov et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Subunit mass fingerprinting of mitochondrial complex I

(2008) Nina Morgner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY