Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I

Global collective motions in the mammalian and bacterial respiratory complex I

(2018) Andrea Di Luca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory Complex I inBos taurusandParacoccus denitrificansPumps Four Protons across the Membrane for Every NADH Oxidized

(2017) Andrew J. Y. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe–S Cluster N2 in Respiratory Complex I

(2017) Nolwenn Le Breton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Terminal Electron–Proton Transfer Dynamics in the Quinone Reduction of Respiratory Complex I

(2017) Ana P. Gamiz-Hernandez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I

(2017) Justin G. Fedor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetics and dynamics of a light-driven sodium-pumping rhodopsin

(2017) Carl-Mikael Suomivuori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Symmetry-related proton transfer pathways in respiratory complex I

(2017) Andrea Di Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Limb proportions show developmental plasticity in response to embryo movement

(2017) A. S. Pollard et al.   Scientific Reports

Molecular simulation and modeling of complex I

(2016) Gerhard Hummer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory complex I: A dual relation with H + and Na + ?

(2016) Paulo J. Castro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ischemic A/D transition of mitochondrial complex I and its role in ROS generation

(2016) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I

(2016) Judy Hirst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial complex I

(2016) Christophe Wirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Electron Tunneling Rates in Respiratory Complex I Are Tuned for Efficient Energy Conversion

(2015) Simon de Vries et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ATP Synthase

(2015) Wolfgang Junge et al.   Annual Review of Biochemistry

Amilorides Bind to the Quinone Binding Pocket of Bovine Mitochondrial Complex I

(2015) Masatoshi Murai et al.   BIOCHEMISTRY

Conserved Amino Acid Residues of the NuoD Segment Important for Structure and Function of Escherichia coli NDH-1 (Complex I)

(2015) Prem Kumar Sinha et al.   BIOCHEMISTRY

New Perspectives on Proton Pumping in Cellular Respiration

(2015) Mårten Wikström et al.   CHEMICAL REVIEWS

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

(2015) Febin Varghese et al.   HUMAN MOLECULAR GENETICS

Constraining the Lateral Helix of Respiratory Complex I by Cross-linking Does Not Impair Enzyme Activity or Proton Translocation

(2015) Shaotong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A giant molecular proton pump: structure and mechanism of respiratory complex I

(2015) Leonid A. Sazanov   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How release of phosphate from mammalian F1-ATPase generates a rotary substep

(2015) John V. Bason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-induced activation of the proton pump in the respiratory complex I

(2015) Vivek Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I

(2015) Katarzyna Kmita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Characterisation of the active/de-active transition of mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mechanism of proton translocation in respiratory complex I from molecular dynamics

(2014) Pengli Tan et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Long-Range Electron Tunneling

(2014) Jay R. Winkler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native structure of photosystem II at 1.95 Å resolution viewed by femtosecond X-ray pulses

(2014) Michihiro Suga et al.   NATURE

Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase

(2014) Julia Steuber et al.   NATURE

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Chemomechanical coupling of human mitochondrial F1-ATPase motor

(2014) Toshiharu Suzuki et al.   Nature Chemical Biology

Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I

(2014) V. R. I. Kaila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathway of binding of the intrinsically disordered mitochondrial inhibitor protein to F1-ATPase

(2014) J. V. Bason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

(2013) James A. Birrell et al.   BIOCHEMICAL JOURNAL

Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I

(2013) Marion Babot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Accessory subunits of mitochondrial complex I

(2013) Katarzyna Kmita et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

Oxidoreduction properties of bound ubiquinone in Complex I from Escherichia coli

(2013) Marina Verkhovskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The antiporter-like subunit constituent of the universal adaptor of complex I, group 4 membrane-bound [NiFe]-hydrogenases and related complexes

(2013) Ana P. Batista et al.   BIOLOGICAL CHEMISTRY

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Study of ion translocation by respiratory complex I. A new insight using 23Na NMR spectroscopy

(2012) Ana P. Batista et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tightly-bound ubiquinone in the Escherichia coli respiratory Complex I

(2012) Michael Verkhovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The coupling mechanism of respiratory complex I — A structural and evolutionary perspective

(2012) Rouslan G. Efremov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

EPR detection of two protein-associated ubiquinone components (SQNf and SQNs) in the membrane in situ and in proteoliposomes of isolated bovine heart complex I

(2012) Tomoko Ohnishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A missing link between complex I and group 4 membrane-bound [NiFe] hydrogenases

(2012) Bruno C. Marreiros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Asp563 of the horizontal helix of subunit NuoL is involved in proton translocation by the respiratory complex I

(2012) Stefan Steimle et al.   FEBS LETTERS

Energy-converting respiratory Complex I: On the way to the molecular mechanism of the proton pump

(2012) Marina Verkhovskaya et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+Antiporter

(2012) Philippa G. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stoichiometry of proton translocation by respiratory complex I and its mechanistic implications

(2012) M. Wikstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring Interactions between the 49 kDa and ND1 Subunits in Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) by Photoaffinity Labeling

(2011) Masatoshi Murai et al.   BIOCHEMISTRY

Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase

(2011) Sayo Nakanishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A two-state stabilization-change mechanism for proton-pumping complex I

(2011) Ulrich Brandt   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Charge separation in Photosystem II: A comparative and evolutionary overview

(2011) Tanai Cardona et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Understanding mitochondrial complex I assembly in health and disease

(2011) Masakazu Mimaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural Contribution of C-terminal Segments of NuoL (ND5) and NuoM (ND4) Subunits of Complex I fromEscherichia coli

(2011) Jesus Torres-Bacete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Model of the Proton Translocation Mechanism of Complex I

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantum Electron Tunneling in Respiratory Complex I

(2011) Tomoyuki Hayashi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing the mechanistic role of the long α-helix in subunit L of respiratory Complex I from Escherichia coli by site-directed mutagenesis

(2011) Galina Belevich et al.   MOLECULAR MICROBIOLOGY

Structure of the membrane domain of respiratory complex I

(2011) Rouslan G. Efremov et al.   NATURE

Mutagenesis of the L, M, and N Subunits of Complex I from Escherichia coli Indicates a Common Role in Function

(2011) Jose Michel et al.   PLoS One

Functional Dissection of the Proton Pumping Modules of Mitochondrial Complex I

(2011) Stefan Dröse et al.   PLOS BIOLOGY

The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Determination of the intrinsic redox potentials of FeS centers of respiratory complex I from experimental titration curves

(2010) Emile S. Medvedev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cyanobacterial NDH-1 complexes: Novel insights and remaining puzzles

(2010) Natalia Battchikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Proton-Coupled Electron Transfer in Cytochrome Oxidase

(2010) Ville R. I. Kaila et al.   CHEMICAL REVIEWS

Quantum Chemical Studies of Proton-Coupled Electron Transfer in Metalloenzymes

(2010) Per E. M. Siegbahn et al.   CHEMICAL REVIEWS

Theory of Coupled Electron and Proton Transfer Reactions

(2010) Sharon Hammes-Schiffer et al.   CHEMICAL REVIEWS

A new hypothesis on the simultaneous direct and indirect proton pump mechanisms in NADH-quinone oxidoreductase (complex I)

(2010) Tomoko Ohnishi et al.   FEBS LETTERS

The Membrane Subunit NuoL(ND5) Is Involved in the Indirect Proton Pumping Mechanism ofEscherichia coliComplex I

(2010) Eiko Nakamaru-Ogiso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron tunneling in respiratory complex I

(2010) T. Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Proton-Coupled Electron Transfer in Biology: Results from Synergistic Studies in Natural and Model Systems

(2009) Steven Y. Reece et al.   Annual Review of Biochemistry

Reactions of the Flavin Mononucleotide in Complex I: A Combined Mechanism Describes NADH Oxidation Coupled to the Reduction of APAD+, Ferricyanide, or Molecular Oxygen

(2009) James A. Birrell et al.   BIOCHEMISTRY

Electrostatics of the FeS clusters in respiratory complex I

(2009) Vernon A. Couch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanism and energetics by which glutamic acid 242 prevents leaks in cytochrome c oxidase

(2009) Ville R.I. Kaila et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Critical Roles of Subunit NuoH (ND1) in the Assembly of Peripheral Subunits with the Membrane Domain ofEscherichia coliNDH-1

(2009) Prem Kumar Sinha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Electrostatic Interactions Between FeS Clusters in NADH:Ubiquinone Oxidoreductase (Complex I) from Escherichia coli†

(2008) Liliya Euro et al.   BIOCHEMISTRY

Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I)

(2008) Liliya Euro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of the invariant glutamate 95 in the catalytic site of Complex I from Escherichia coli

(2008) Liliya Euro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Real-time electron transfer in respiratory complex I

(2008) M. L. Verkhovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA